CTRP5 promotes transcytosis and oxidative modification of low-density lipoprotein and the development of atherosclerosis

Li, Chang; Chen, Jia Wei; Liu, Zhu Hui; Shen, Ying; Ding, Feng; Gu, Gang; Li, Jun; Qiu, Jia Pei; Gao, Jie; Zhang, Rui Yan; Shen, Wei Feng; Wang, Xiao Qun; Lin, Longnian

doi:10.1016/j.atherosclerosis.2018.09.037

Cited by 46 publications

(34 citation statements)

References 44 publications

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“…It inhibits adiponectin and resistin release in a dose-dependent manner 16 . Simultaneously, CTRP5 can promote transcytosis and oxidative modification of low-density lipoprotein and accelerate atherosclerosis development 23 . Studies have shown that CTRP5 can be used as a biomarker for potential new inflammatory chronic obstructive pulmonary disease and in patients with coronary in-stent restenosis since serum CTRP5 levels are significantly elevated 24 .…”

Section: Discussionmentioning

confidence: 99%

Implications of C1q/TNF-related protein superfamily in patients with coronary artery disease

Zhang

Liu

et al. 2020

Sci Rep

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The C1q complement/TNF-related protein superfamily (CTRPs) displays differential effects on the regulation of metabolic homeostasis, governing cardiovascular function. However, whether and how they may serve as predictor/pro-diagnosis factors for assessing the risks of coronary artery disease (CAD) remains controversial. Therefore, we performed a clinical study to elaborate on the implication of CTRPs (CTRP1, CTRP5, CTRP7, and CTRP15) in CAD. CTRP1 were significantly increased, whereas CTRP7 and CTRP15 levels were decreased in CAD patients compared to the non-CAD group. Significant differences in CTRP1 levels were discovered between the single-and triple-vascular-vessel lesion groups. ROC analysis revealed that CTRP7 and CTRP15 may serve as CAD markers, while CTRP1 may serve as a marker for the single-vessel lesion of CAD. CTRP1 and CTRP5 can serve as markers for the triple-vessel lesion. CTRP1 may serve as an independent risk predictor for triple-vessel lesion, whereas CTRP15 alteration may serve for a single-vessel lesion of CAD. CTRP1 may serve as a novel superior biomarker for diagnosis of severity of vessel-lesion of CAD patients. CTRP7, CTRP15 may serve as more suitable biomarker for the diagnosis of CAD patients, whereas CTRP5 may serve as an independent predictor for CAD. These findings suggest CTRPs may be the superior predictive factors for the vascular lesion of CAD and represent novel therapeutic targets against CAD. Coronary artery disease (CAD) is one of the major cardiovascular diseases, which has a serious impact on human health 1. CAD is a group of diseases including myocardial infarction, sudden angina pectoris, unstable angina pectoris, myocardial infarction, and sudden coronary death 2. Multiple risk factors for CAD have been identified, which are highly associated with metabolism influencer/regulators including obesity, hypertension, dyslipidemia, diabetes, smoking, gender, age, etc. 3. However, the sensitivity of the indicators limits the prediction and prognosis of CAD. Identification of new marker or indicator is in great need. Previous studies suggest that adipokines, well-defined adipocyte endocrine factors, are important determinants for cardiovascular disorders with or without diabetes. Previous investigations implicate adiponectin (APN)'s circulationary level is negatively associated with patients who suffered coronary artery disease and 4. CTRP (C1q complement/TNF-related protein) as a newly discovered family have shown diversity and wide distribution. Some of CTRP family members have similar metabolic effects with that of adiponectin, whereas others exert opposite effect as that adiponectin. Although emerging evidence suggests that CTRPs may serve as indicators for metabolic disorders, whether and how CTRPs may display its own unique potential relationship in predicting disease, especially cardiovascular disorders, is largely under-investigated. CTRP family contains 15 family members (CTRP1 to CTRP15). Their functions display the differences and are highly related to their distribut...

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Section: Discussionmentioning

confidence: 99%

Implications of C1q/TNF-related protein superfamily in patients with coronary artery disease

Zhang

Liu

et al. 2020

Sci Rep

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“…The collagen fibers produced by smooth muscle cells migrating to plaques are the main source of fibrous caps in plaques, and smooth muscle cells in the fibrous cap are decreased (30,31). If inflammatory cells lead to death of smooth muscle cells, macrophages are increased, and thin fibrous caps are prone to rupture, so the plaque stability declines and they rupture easily (32,33). Therefore, inhibiting the macrophage infiltration and preventing the decrease of smooth muscle cells in plaques are the therapeutic goals for stabilizing plaques.…”

Section: Discussionmentioning

confidence: 99%

Tacrolimus reduces atherosclerotic plaque formation in ApoE-/- mice by inhibiting NLRP3 inflammatory corpuscles

Xiao¹,

Shang²,

Sun³

2019

Exp Ther Med

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Effect of tacrolimus on atherosclerotic plaques and its influence on Nod-like receptor protein 3 (NLRP3) inflammatory pathway were studied by establishing the mouse model of atherosclerosis. The mice were divided into 3 groups: C57BL/6 mouse group (WT group), ApoE-/mouse group (ApoE-/group) and ApoE-/mouse + tacrolimus intervention group (ApoE-/-+ Tac group). The area of atherosclerotic plaques and the pathological morphologic changes were observed. The NLRP3, interleukin-1β (IL-1β), IL-18, NLRP3 inflammatory corpuscles, pro-inflammatory factors IL-1β and IL-18 in the aorta were analyzed. The area of atherosclerotic plaques in ApoE-/mice was increased significantly, and it was significantly reduced after tacrolimus intervention. After tacrolimus intervention, the arterial intima became obviously thinner and no obvious cholesterol crystals were observed. The macrophage infiltration in atherosclerotic plaques was significantly increased, and the content of smooth muscle cells was also increased. The levels of serum IL-1β, IL-18 and NLRP3 in ApoE-/mice were significantly increased, and they remarkably declined after tacrolimus intervention. ROS content in atherosclerotic plaques was increased in ApoE-/mice, and it remarkably declined after tacrolimus intervention. The protein content of NLRP3, ASC, Casp-1, IL-1β and IL-18 in the aorta in ApoE-/mice was remarkably increased, and they were inhibited to some extent after tacrolimus intervention. In conclusion, it is speculated that tacrolimus may reduce the formation of AS through inhibiting ROS in macrophages and activation of NLRP3 inflammatory corpuscles and reducing the release of IL-1β and IL-18.

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“…As an important nding, we also found that CTRP5 circulating levels and CTRP1/CTRP5 ratio might be two independent predictors for the cIMT index. It has been demonstrated that serum CTRP5 levels were signi cantly increased in patients with CAD and positively correlated with the extent and severity of atherosclerosis in these patients (51). It seems that decreased levels of CTRP5 may be linked to cardiovascular complications in T2D patients.…”

Section: Discussionmentioning

confidence: 97%

The CTRP5 Circulating Levels and the Ratio of CTRP1 to CTRP5 in Plasma are Significant Predictors for Carotid Intima-Media Thickness(cIMT) value in Patients with type 2 diabetes: A Preliminary Study

Majidi

Emamgholipour

Omidifar

et al. 2020

Preprint

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Background: There is growing evidence that the C1qTNF-related protein (CTRP) family has a crucial role in the physiology and pathophysiology of metabolic disorders such as Type 2 Diabetes (T2D) and obesity. We sought to identify the association of CTRP1 and CTRP5 circulating levels with various obesity parameters such as visceral adipose tissue (VAT) thickness, visceral adiposity index (VAI), and with carotid intima-media thickness (cIMT) in patients with T2D and healthy subjects.Methods: This preliminary study consisted of men with T2D (n=42) and men without T2D (n=42) . cIMT and VAT thickness measurement was performed using an Accuvix XQ ultrasound. Circulating levels of CTRP1, CTRP5, and adiponectin were measured by enzyme-linked immunosorbent assay (ELISA).Results: CTRP-1 and CTRP1/CTRP5 ratio were markedly higher in patients with T2D compared to controls (p < 0001 and p = 0004 respectively). Interestingly, binominal logistic regression revealed that a higher circulating level of CTRP1 was associated with the presence of T2D (odds ratio [OR]: 1.009 [95% CI: 1.004-1.015]; P=.001). CTRP1 circulating levels were correlated with WHR, VAT, and HOMA-IR in the whole population study. Also, we observed that the ratio of CTRP1 to CTRP5 in plasma (β = 0.648, P=0.005) and CTRP5 circulating levels (β = 0.444, P=0.049) are significant predictors for cIMT value.Conclusions: Our results indicated that CTRP1 and CTRP5 concentrations were correlated with atherosclerosis in men with T2D and these adipokines might have a causal role for cardiometabolic risk in T2D.However, more studies in large sample sizes are required to clarify the role of CTRPs in T2D pathogenesis.

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CTRP5 promotes transcytosis and oxidative modification of low-density lipoprotein and the development of atherosclerosis

Cited by 46 publications

References 44 publications

Implications of C1q/TNF-related protein superfamily in patients with coronary artery disease

Implications of C1q/TNF-related protein superfamily in patients with coronary artery disease

Tacrolimus reduces atherosclerotic plaque formation in ApoE-/- mice by inhibiting NLRP3 inflammatory corpuscles

The CTRP5 Circulating Levels and the Ratio of CTRP1 to CTRP5 in Plasma are Significant Predictors for Carotid Intima-Media Thickness(cIMT) value in Patients with type 2 diabetes: A Preliminary Study

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