CT features of hepatic metastases from hepatoid adenocarcinoma

Chang, Moon Ho; Kim, Hye Jin; Park, Seung Hyun; Kim, Hyunki; Choi, Dong Kyu; Lim, Joon Seok; Park, Mi-Suk; Kim, Do Young; Kim, Honsoul

doi:10.1007/s00261-017-1150-3

Cited by 10 publications

(11 citation statements)

References 22 publications

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“…However, a recent case series revealed that less than two-thirds of HA demonstrates HCC-like contrast enhancement, noting considerable variability in enhancement pattern. 11 Inconsistent contrast enhancement, as was seen in our patient, is unlike HCC, where the diagnosis can often be made radiographically due to its characteristic early arterial enhancement and venous washout. Serum AFP is elevated in the majority of HA cases.…”

Section: Discussionmentioning

confidence: 51%

Hepatoid Adenocarcinoma of the Rectum With Liver Metastasis in a Patient With Ulcerative Colitis

et al. 2019

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Hepatoid adenocarcinoma (HA) is a rare malignant tumor of extrahepatic origin that morphologically and immunophenotypically resembles hepatocellular carcinoma. We report a case of rectal HA with hepatic metastasis arising in a 38-year-old male with a history of ulcerative colitis. Despite elevated alpha-fetoprotein, contrast enhancement of the hepatic mass was not consistent with hepatocellular carcinoma. Immunohistochemistry revealed the diagnosis, and the patient was started on palliative chemotherapy. Colorectal HA should be considered when evaluating malignant lesions in the setting of inflammatory bowel disease and can be distinguished from other tumors based on alpha-fetoprotein, imaging, and immunostaining.

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Section: Discussionmentioning

confidence: 51%

Hepatoid Adenocarcinoma of the Rectum With Liver Metastasis in a Patient With Ulcerative Colitis

et al. 2019

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“…However, with obvious lesions encountered on imaging, it is not always easy to define the true nature of this imaging feature. A spectrum of imaging features of HAS liver metastasis has been reported 27,28. On dynamic CT of the liver, an arterial hyperattenuation followed by a late wash is common.…”

Section: Resultsmentioning

confidence: 99%

“…Notably, this pattern resembles a pattern similar to that of HCC. However, if an isolated portal vein thrombosis and a tendency for tumor necrosis are encountered related to liver nodules, a diagnosis of HAS is more likely 27,28. Magnetic resonance imaging (MRI) adds to the tools, and MRI diffusion-weighted imaging was recently introduced for the identification and diagnosis of primary HAS 29…”

Section: Resultsmentioning

confidence: 99%

<p>Therapeutic Approaches to Gastric Hepatoid Adenocarcinoma: Current Perspectives</p>

Søreide¹

2019

TCRM

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Hepatoid adenocarcinoma of the stomach (HAS) is a rare subgroup of gastric cancer (GC). Morphologically, this tumor exhibits both adenocarcinomatous and hepatocellular differentiation, and most tumors show immunohistochemical staining for alpha-fetoprotein (AFP) or elevated AFP serum levels. The diagnosis of HAS is frequently delayed, and at least half of patients have advanced disease at the time of diagnosis. Despite a lack of evidence, treatment approaches have mostly followed principles for the treatment of common gastric cancer (CGC), including radical surgery in eligible patients with curative intent. The indications for and the type of adjuvant systemic treatments remain unclear. Additionally, there is a lack of evidence allowing any firm conclusions to be drawn regarding the best treatment for patients with metastatic HAS (mHAS). Chemotherapy regimens, including cisplatin-based chemotherapy, are considered the most efficient first-line systemic treatment in advanced situations. Their combination with targeted therapy (i.e., trastuzumab) in HER2-positive tumors seems promising. The rarity of these patients and the scarce and heterogeneous literature on this particular subgroup of GC make it difficult to provide any robust evidence for the clinical management of patients with HAS.

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“…Based on the differential expression of SALL4 and the presence of an intramucosal transition with the conventional component, the gastric lesion and HCC were considered as separate primary cancers. After gastrectomy, multiple liver lesions were clinically diagnosed as recurrent HCC; however, some radiological studies reported that liver metastasis from hepatoid adenocarcinoma of the stomach shared many imaging similarities with HCC [21,22]. Although the gastric lesion was limited to the lamina propria, submucosal lymphovascular invasion was identified.…”

Section: Discussionmentioning

confidence: 99%

Alpha-Fetoprotein-Producing Early Gastric Cancer with Intramucosal Hepatoid and Fetal Enteric Differentiation

Iwaya

Riddell

Asano

et al. 2020

Case Rep Gastroenterol

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Alpha-fetoprotein (AFP)-producing gastric carcinomas (AFPGCs) are relatively rare tumors known to have a poor prognosis and commonly found as advanced lesions. Histologically, AFPGCs have been described as having hepatoid and fetal enteric (enteroblastic) morphology and are associated with conventional adenocarcinomas. Prior studies reported a hepatoid component present only in invasive areas and hypothesized that AFPGCs may develop hepatoid features during the process of tumor invasion. We report three cases of AFP-producing early gastric cancer which had an intramucosal hepatoid component. Immunohisto

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CT features of hepatic metastases from hepatoid adenocarcinoma

Abstract: The imaging features of HAC liver metastasis were varied. Arterial phase enhancement coupled with venous phase washout (resembling HCC imaging features) was a major finding, but arterial phase hypo-enhancement (distinct from HCC imaging features) was also frequently encountered.

Cited by 10 publications

References 22 publications

Hepatoid Adenocarcinoma of the Rectum With Liver Metastasis in a Patient With Ulcerative Colitis

Hepatoid Adenocarcinoma of the Rectum With Liver Metastasis in a Patient With Ulcerative Colitis

<p>Therapeutic Approaches to Gastric Hepatoid Adenocarcinoma: Current Perspectives</p>

Alpha-Fetoprotein-Producing Early Gastric Cancer with Intramucosal Hepatoid and Fetal Enteric Differentiation

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