CT-Diagnosed Mesenteric Alterations in Patients with Non-Hodgkin’s Lymphoma: A Population-Based Study

Abstract

Background: Mesenteric alterations are associated with non-Hodgkin’s lymphoma (NHL), but the frequency and prognostic value of mesenteric alterations are unknown in patients with NHL. Patients and Methods: We retrospectively screened 120 patients that were treated for NHL between January 1996 and December 2001 for the presence of mesenteric alterations, defined on computed tomography (CT) scans as nodular or diffuse infiltration of the abdominal mesentery with increased density of mesenteric fat. Results: 21 patients (17.5%) had radiological findings of mesenteric alterations at the time of the initial NHL diagnosis. Mesenteric alterations were significantly associated with mesenteric lymphadenopathy (p = 0.01). In about 50% of the patients, mesenteric alterations could not be explained by direct mesenteric tumour invasion or overt lymphatic obstruction. Patients with initial findings of mesenteric alterations tended to have a better 4-year survival as compared to patients without such findings (79 vs. 43%, p = 0.11). The International Prognostic Index (IPI) score was the only independent predictor of survival in the multivariate analysis. Conclusion: This retrospective screening study found a moderate prevalence of mesenteric alterations in patients with various subtypes of NHL. The diagnostic and prognostic value of mesenteric alterations should be further assessed in prospective studies.

Multidetector-row computed tomography findings of sclerosing mesenteritis with associated diseases and its prevalence

“…[1][2][3][4][5][6][7][8][9][10][11][12][13] Because the condition is considered a single clinical disease, all of these terms result in remarkable complexity. This confusion may cause ineffective exchange of information between pathologist, radiologist, and clinician and may even give rise to inappropriate treatment of the disease.…”

“…1 Ultrasonography, CT, and MRI have been used to evaluate sclerosing mesenteritis. [7][8][9][10][11][12] The characteristic features seen on US are a well-defined, homogeneous hyperechoic fatty mass at the mesenteric root, A B Fig. 4.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12][13] Even though its etiology is unknown, this entity is often associated with other infl ammatory disorders such as retroperitoneal fi brosis, sclerosing cholangitis, Riedel thyroiditis, and orbital pseudotumor. 3 The rate of malignancy, especially urogenital and gastrointestinal adenocarcinomas or lymphomas, has also been reported to be as high as 69.3%.…”

“…1 Ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI) have been used to evaluate the mesenteric diseases. [7][8][9][10][11][12] Various pathological conditions such as edema, infl ammation, neoplasm, trauma, and hemorrhage may increase the mesenteric fat attenuation on CT, and the condition is called misty mesentery. Therefore, these entities should be included in the differential diagnosis of sclerosing mesenteritis.…”

Mesenteric panniculitis: an update

“…In about 50% of the patients, mesenteric changes could not be explained by direct infiltration of the mesentery by lymphoma or by lymphatic obstruction. Patients with mesenteric changes tended to have a better 4-year survival as compared to patients without such changes [42]. Bechade et al reviewed the clinicopathological and radiological findings in seven patients with mesenteric panniculitis (four men and three women).…”