CT and MR Imaging Features of Primary Central Nervous System Lymphoma in Norway, 1989–2003

Haldorsen, Ingfrid S.; Kråkenes, Jostein; Krossnes, Bård Kronen; Mella, Olav; Espeland, Ansgar

doi:10.3174/ajnr.a1447

Cited by 112 publications

(138 citation statements)

References 43 publications

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“…These lesions are predominantly supratentorial (Koeller et al, 1997;Buhring et al, 2001). Ring like enhancement is rarely observed in immunocompetent patients, but can be commonly found in immunocompromised patients (Johnson et al, 1997;Haldorsen et al, 2008;2009;, Sutherland et al, 2012. In our study ring enhancement was observed in only two cases, one of which was labeled as Tuberculoma on radiological assessment.…”

Section: Discussionmentioning

confidence: 43%

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Primary Central Nervous System Lymphoma: A Clinicopathological and Cytomorpholgical Study from A Tertiary Care Centre in Chennai, India

Ambroise

Ghosh²,

Mallikarjuna³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: The aim of this study was to analyze the clinicopathological and immunohistochemical features of primary central nervous system lymphoma (PCNSL) cases occurring in Indian patients and also study the utility of the crush smear preparation in intraoperative diagnosis. Materials and Methods: The immune status, clinical, radiological details, immunohistochemical profile, histopathological findings and cytological features in smear preparation of 32 cases of PCNSL were analyzed. Patients with systemic NHL and skull-base lymphomas were excluded. Results: The mean age of our patients was 52 years with a male: female ratio 1:1. A periventricular location was found in 62.5% of patients. None of our PCNSL cases were associated with AIDS. All cases except one were diffuse large B-cell lymphomas. Intraoperative diagnosis using crush smears allowed correct prediction in 93% of cases. Conclusions: Our study shows that PCNSL is seen predominantly in immunocompetent patients in India .The age of presentation is relatively young as compared to the West. Our study also stresses the utility of crush smear preparation in establishing an intraoperative diagnosis.

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Section: Discussionmentioning

confidence: 43%

“…In a previous study of non -AIDS associated PCNSL, 5% of patients had received immunosuppressive medications for medical conditions like ulcerative colitis, renal transplantation, rheumatoid arthritis and Wegener granulomatosis (Haldorsen et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Primary Central Nervous System Lymphoma: A Clinicopathological and Cytomorpholgical Study from A Tertiary Care Centre in Chennai, India

Ambroise

Ghosh²,

Mallikarjuna³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…2,3 Typical MR imaging features of PCNSLs are characterized by their periventricular locations, well-defined margin, moderate or marked edema, and intense and homogeneous nodular enhancement and are usually easy to correctly diagnose. [4][5][6] However, some patients present with atypical MR imaging features, commonly those of heterogeneous enhancement, such as patchy enhancement, streaky enhancement without mass formation, or even no enhancement. [6][7][8][9] Demyelinating diseases of the CNS are pathologic entities that are frequently encountered in clinical practice.…”

mentioning

confidence: 99%

“…[4][5][6] However, some patients present with atypical MR imaging features, commonly those of heterogeneous enhancement, such as patchy enhancement, streaky enhancement without mass formation, or even no enhancement. [6][7][8][9] Demyelinating diseases of the CNS are pathologic entities that are frequently encountered in clinical practice. When such lesions appear as solitary masses Ͼ2 cm in the longest diameter, they are defined as tumefactive demyelinating lesions (TDLs), and they can cause symptoms mimicking brain neoplasms and can be associated with variable enhancement on MR imaging.…”

mentioning

confidence: 99%

Utility of Proton MR Spectroscopy for Differentiating Typical and Atypical Primary Central Nervous System Lymphomas from Tumefactive Demyelinating Lesions

Kim

et al. 2013

American Journal of Neuroradiology

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“…Diffusion within the tumor is considered a surrogate marker of tumor cellularity, and water diffusion is often restricted in PLCNSLs because they are highly cellular tumors [11] . In our study, we did not observe a clear tendency in DWI, although in immunocompetent patients, twice as many lesions were restricted than in immunodeficient patients (perhaps due to the high percentage of necrosis).…”

Section: Mri Featuresmentioning

confidence: 99%

Findings at presentation in primary CNS diffuse large B-cell lymphoma of the brain: A comparison of immunocompetent and immunodeficient patients

Sampedro

Corroto²,

Arias³

et al. 2013

JBGC

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Background/Objectives: Primary central nervous system lymphoma (PCNSL) is a rare tumour with poor prognosis. Due to the increased number of patients with PCNSL over the past two decades our purpose are to describe magnetic resonance imaging (MRI) and Computed Tomography (CT) findings in (PCNSL) of the brain, and to study the differences between immunocompetent and immunodeficient patients with PCNSL. Methods:A retrospective, descriptive study was performed with 59 patients diagnosed of PCNSL in two hospitals from 1997 to 2010. Immunocompetent (n=38) and immunodeficient (n=21) patients were compared and differences between both groups were analyzed. Patients were evaluated according to sex, age, median time from clinical symptoms presentation to pathologic diagnosis, clinical symptoms, location, number of lesions, size, MRI and CT characteristics. Significance was defined as p < 0.05.Results: MRI findings: 50% of lesions in immunocompetent and 52.4% in immunodeficient group were heterogeneous, 89.5% of lesions in immunocompetent and 85,7% in immunodeficient were hypo-isointense on T1WI; 63.2% of lesions in immunocompetent and 76.2% in immunodeficient group were hyperintense on T2WI. CT images: 48.39% of lesions in immunocompetent and 20% in immunodeficient group were hyperdense. Statistically significant differences between immunocompetent and immunodeficient patients were found when evaluating the age (p < 0.000) and median time from clinical symptoms presentation to pathologic diagnosis (p < 0.008).Conclusions: MRI and CT are able to define imaging characteristics of PCNSL, promoting a quick diagnosis. There are no significant differences between immunocompetent and immunodeficient patients for MR and CT features.

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CT and MR Imaging Features of Primary Central Nervous System Lymphoma in Norway, 1989–2003

Cited by 112 publications

References 43 publications

Primary Central Nervous System Lymphoma: A Clinicopathological and Cytomorpholgical Study from A Tertiary Care Centre in Chennai, India

Primary Central Nervous System Lymphoma: A Clinicopathological and Cytomorpholgical Study from A Tertiary Care Centre in Chennai, India

Utility of Proton MR Spectroscopy for Differentiating Typical and Atypical Primary Central Nervous System Lymphomas from Tumefactive Demyelinating Lesions

Findings at presentation in primary CNS diffuse large B-cell lymphoma of the brain: A comparison of immunocompetent and immunodeficient patients

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