CT and IVU in the diagnosis of Wilms' tumour A comparative study

Damgaard-Pedersen, Karen

doi:10.1007/bf01092946

Cited by 15 publications

(4 citation statements)

References 9 publications

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“…[13] However, IVU was inferior to CT in differentiating between solid tumors and benign lesions such as cysts and hydronephrosis. [13] Scott et al [14] stated that tumors that crossed the midline were suggestive of neuroblastomas rather than Wilms' tumor and is better evaluated and confirmed with CT than IVU. Contrary to this claim but in tandem with the findings of Scott et al [14] in their study, the present study revealed that majority of the tumors crossed the midline.…”

Section: Discussionmentioning

confidence: 99%

“…IVU can assess physiological or functional ability of the diseased kidneys and also studies have shown that IVU was helpful in pre-operative differentiation between neuroblastoma and Wilms’ tumor as it gives supplementary information on the size and extent of the solid nature of the tumor. [13] However, IVU was inferior to CT in differentiating between solid tumors and benign lesions such as cysts and hydronephrosis. [13] Scott et al .…”

Section: Discussionmentioning

confidence: 99%

“…[13] However, IVU was inferior to CT in differentiating between solid tumors and benign lesions such as cysts and hydronephrosis. [13] Scott et al . [14] stated that tumors that crossed the midline were suggestive of neuroblastomas rather than Wilms’ tumor and is better evaluated and confirmed with CT than IVU.…”

Section: Discussionmentioning

confidence: 99%

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Pattern of computed tomography scan findings in children with Wilms’ tumor in a tertiary hospital in Lagos, Nigeria

Olukayode

Osuoji

Rachael

et al. 2014

Indian J Med Paediatr Oncol

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Context:Abnormal abdominal distension in a child is usually a source of great concern and apprehension in both the parents and the pediatric surgeon. Although Wilms’ tumor is the most common malignant abdominal childhood tumor, usually causing abdominal distension, many other less common causes can also result in abdominal distension. Therefore, early diagnosis of Wilms’ tumor and distinguishing it from all these other causes is essential.Aims:We intend to document the pattern of computed tomography (CT) scan findings in patients with Wilms’ tumor and the peculiarity of its radiological presentation in this environment, highlighting its accuracy and advantages over other imaging modalities.Settings and Design:This is a prospective descriptive study conducted between January, 2011 to January 2012, where all infants, 6-96 months of age, who were suspected to have Wilms’ tumor were made to undergo CT scan examination as part of their management work-up. It was carried out in a teaching hospital.Subjects and Methods:The study performed on 12 children age range of 6-96 months old underwent abdominal CT scans as part of their clinical work-up using a GE Hi-speed dual CT scanner®. Pre- and post-contrast images were acquired and assessed by the radiologists. They were operated and their radiological and histopathology results were correlated.Statistical Analysis:All data was entered into a Microsoft word excel spread sheet and analyzed by simple analysis. Percentages and proportions were determined for categorical variables.Results:Of the 12 patients seen, nearly 75% were males, with a male to female ratio of 3:1 and an average age of 37 months. The right sided tumors were slightly more than the left and nearly 25% were bilateral. Approximately 17% showed punctuate calcifications. Heterogeneous contrast enhancement was seen in all the cases, vascular encasement in three and lymphadenopathy in six cases. There was no bony involvement in any of them but 75% of the masses seen, crossed the midline. Histological confirmation of Wilms’ tumor was obtained in all cases.Conclusions:Majority of the tumors seen in this study crossed the midline and a few of them showed calcification. CT scan is relevant and accurate in investigating children with Wilms’ tumor as it reveals concomitant lesions with involvement of the abdominal vessels and lymph nodes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pattern of computed tomography scan findings in children with Wilms’ tumor in a tertiary hospital in Lagos, Nigeria

Olukayode

Osuoji

Rachael

et al. 2014

Indian J Med Paediatr Oncol

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“…Before the ultrasonography (USG) and tomography era, direct radiograph and intravenous urography were used widely. USG and contrast-enhanced tomography (CT) of the abdomen are more effective diagnostic techniques in the staging and follow-up of patients [34,35,36,37,38], as they can detect tumor size, invasion, and tumoral involvement of the lymph nodes. Doppler USG shows vena cava invasion, which is important for determining the preoperative treatment strategy.…”

Section: Histopathologymentioning

confidence: 99%

Wilms’ Tumor in Children: An Overview

Varan

2008

Nephron Clin Pract

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Wilms’ tumor is the most frequently occurring renal tumor in children and is one of the most treatment-responsive tumors. A tumor-suppressor gene and other genetic abnormalities have been implicated in its etiology. In addition, patients with several congenital anomalies, such as Beckwith-Wiedemann syndrome, WAGR syndrome, and Denys-Drash syndrome, have an increased risk of Wilms’ tumor. Previously, a three-drug chemotherapy regimen with surgery and radiotherapy was used with patients in all stages. Now, patients with early-stage Wilms’ tumor are treated with a two-drug regimen without radiotherapy, whereas those in advanced stages still receive the three-drug regimen and radiotherapy. Two large collaborative groups – the National Wilms’ Tumor Study Group (NWTS) in the United States and the International Society of Pediatric Oncology (SIOP) in Europe – are involved in Wilms’ tumor management, which differs in some aspects. Multimodality treatment has been used successfully, and in Europe preoperative strategies are used as well. As the survival rate has now reached 90%, the primary objectives of the physician are to perform nephron-sparing surgery in selected cases and to reduce the dosage and duration of chemotherapy and radiotherapy in appropriate cases. Other renal tumors occur rarely, but have also been treated successfully in the last decade.

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Wilms’ Tumor

Green

1985

Diagnosis and Management of Malignant Solid Tumors in Infants and Children

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CT and IVU in the diagnosis of Wilms' tumour A comparative study

Cited by 15 publications

References 9 publications

Pattern of computed tomography scan findings in children with Wilms’ tumor in a tertiary hospital in Lagos, Nigeria

Pattern of computed tomography scan findings in children with Wilms’ tumor in a tertiary hospital in Lagos, Nigeria

Wilms’ Tumor in Children: An Overview

Wilms’ Tumor

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