Wilms’ Tumor

Green, Daniel M.

doi:10.1007/978-1-4613-2623-6_4

Cited by 13 publications

(10 citation statements)

References 435 publications

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“…In rare cases, the Wilms tumor arises from the renal pelvis and has an appearance similar to botryoid sarcoma. Thus, such tumors are called botryoid Wilms tumor, and exophytic expansion is inconsistent with the concept of typical Wilms tumor [1,2]. As the origin and expansion are unique, the clinical manifestations are also distinct from typical Wilms tumor.…”

Section: Introductionmentioning

confidence: 96%

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Botryoid Wilms tumor: case report and review of literature

Honda

Shima

Onoe

et al. 2000

Pediatric Nephrology

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A rare case of botryoid Wilms tumor is presented. The main clinical manifestations were persistent low-grade fever, malaise, and proteinuria associated with microhematuria. Ultrasonography revealed an echogenic mass in the right kidney, and a contrast-enhanced mass was found in the dilated collecting system by contrast-enhanced computed tomography. The surgically resected tumor was a polypoid, light-yellow, glistening mass that occupied a large part of the renal pelvis and originated from the pelvicaliceal wall. Part of the tumor extended to the proximal ureter, resulting in hydronephrosis in the involved kidney. No parenchymal lesion was observed. Microscopic examination revealed epithelial, stromal, and blastemal components, which indicated Wilms tumor. Infection had occurred in the hydronephrotic kidney, which presumably had caused the major presenting symptoms. The prognosis of our patient and previously reported cases of botryoid Wilms tumor was good compared with that of typical Wilms tumor, since the botryoid type can be detected at an early stage.

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Section: Introductionmentioning

confidence: 96%

“…Wilms tumor usually originates from the renal parenchyma and grows by expanding into the surrounding tissue [1]. In rare cases, the Wilms tumor arises from the renal pelvis and has an appearance similar to botryoid sarcoma.…”

Section: Introductionmentioning

confidence: 97%

Botryoid Wilms tumor: case report and review of literature

Honda

Shima

Onoe

et al. 2000

Pediatric Nephrology

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“…In general, the long-term renal function in patients treated for Wilms tumor is considered to be good [1]. However, the presence of microalbuminuria reported in some studies may indicate that hyperfiltration is associated with an increased risk for subsequent renal damage [4,7].…”

Section: Discussionmentioning

confidence: 98%

“…Advances in surgical techniques and postoperative care, together with the recognition of the sensitivity of Wilms tumor to several chemotherapeutic agents and radiotherapy, have led to a dramatic improvement in the outcome of most patients affected by this tumor [1]. Successful treatment, however, may be associated with damage to various tissues and organs [2].…”

Section: Introductionmentioning

confidence: 99%

Adaptation of renal function after unilateral nephrectomy in children with renal tumors

Donckerwolcke

Coppes

2001

Pediatric Nephrology

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Following treatment, survivors of unilateral Wilms tumor (WT) develop structural and functional changes in the remnant kidney. A disproportional increase in functional over structural changes results in hyperfiltration, a condition that may lead to renal damage. We studied adaptation of renal function after uninephrectomy in ten WT patients and a child with renal cell carcinoma. Glomerular filtration rate (GFR) (measured by inulin and creatinine clearances), renal plasma flow (RPF) by para-aminohippurate (PAH) clearances and segmental tubular Na+ transport were studied before and following a protein load (renal functional reserve). Nine patients showed a well-adapted kidney function with a GFR of 82.27 (+/- 5.6), an RPF of 429.71 (+/- 65.6) ml/min/1.73 m2 and a filtration fracton (FF) of 20%. Absolute proximal Na+ reabsorption was 65.2 (+/- 9.6) ml/min/1.73 m2, distal tubular delivery was 18.2 (+/- 3.9) ml/min/1.73 m2 and absolute distal Na+ reabsorption was 2146 (+/- 435) microM/min. A peculiar finding was the high baseline creatinine clearances (176.17 ml/min/1.73 m2) related to increased baseline tubular creatinine secretion. Over 120 min following the protein load, GFR increased by 20%, RPF by 6% and FF remained unchanged. Absolute proximal reabsorption increased by 20% and distal reabsorption by 22%. While most changes in renal function induced by a protein load are similar in healthy individuals and uninephrectomized patients, a more predominant contribution to Na+ reabsorption by the proximal tubule was noted. Postload fractional proximal reabsorption remained at 77% while in healthy persons a decrease from 77% to 62% was reported. Two patients showed dysfunctional changes following nephrectomy characterized by an increased GFR (130 ml/min/1.73 m2), increased filtration fraction (29%) and inability to increase glomerular and tubular functions following a protein load (loss of functional reserve). The significance of these abnormalities is not known and requires long-term follow-up to evaluate whether hyperfiltration will lead to renal damage.

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“…Wilms' tumour (WT) is the most common malignant tumour of the kidney in children, accounting for approximately 6% of all childhood cancers [1]. Currently, approximately 90% of paediatric WTs are curable using a combination of surgery, chemotherapy and radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Candidate genes and potential targets for therapeutics in Wilms’ tumour

2010

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Wilms' tumour (WT) is the most common malignant renal tumour of childhood. During the past two decades or so, molecular studies carried out on biopsy specimens and tumour-derived cell lines have identified a multitude of chromosomal and epigenetic alterations in WT. In addition, a significant amount of evidence has been gathered to identify the genes and signalling pathways that play a defining role in its genesis, growth, survival and treatment responsiveness. As such, these molecules and mechanisms constitute potential targets for novel therapeutic strategies for refractory WT. In this report we aim to review some of the many candidate genes and intersecting pathways that underlie the complexities of WT biology.

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Wilms’ Tumor

Cited by 13 publications

References 435 publications

Botryoid Wilms tumor: case report and review of literature

Botryoid Wilms tumor: case report and review of literature

Adaptation of renal function after unilateral nephrectomy in children with renal tumors

Candidate genes and potential targets for therapeutics in Wilms’ tumour

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