CSF levels of cytokines in neuro-Behçet's disease

Borhani‐Haghighi, Afshin; Ittehadi, H.; Nikseresht, Alireza; Rahmati, Jamshid; Poorjahromi, S. Ghaffari; Pourabbas, Bahman; Nazarinia, Mohammad Ali; Habibagahi, Zahra; Fattahi, Mohammad Javad; Ghaderi, Abbas

doi:10.1016/j.clineuro.2009.02.001

Cited by 58 publications

(25 citation statements)

References 17 publications

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“…Thus, CSF IL-6 has been shown to be increased in patients with relapsing-remitting NBD (acute NBD), as well as in those with progressive NBD (CP NBD) [6, 18–21]. Consistently, in the present study, CSF IL-6 was elevated in acute NBD as well as in CP NBD, but not in non-NBD.…”

Section: Discussionsupporting

confidence: 88%

Clinical characteristics of neuro-Behcet’s disease in Japan: a multicenter retrospective analysis

et al. 2011

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To delineate the clinical characteristics of neuro-Behçet’s disease (NBD), a multicenter retrospective survey was performed in BD patients who had presented any neurological manifestations between 1988 and 2008. The diagnosis of acute NBD, chronic progressive (CP) NBD, and non-NBD was confirmed by retrospective review of clinical records. Data on a total of 144 patients were collected; 76 with acute NBD, 35 with CP NBD, and 33 with non-NBD. High-intensity lesions on T2-weighted magnetic resonance imaging (MRI) were found in 60.5% of the patients with acute NBD, 54.2% with CP NBD, and 42.4% with non-NBD, whereas brainstem atrophy was observed in 7.5% with acute NBD, 71.4% with CP NBD, and 9.0% with non-NBD. The cerebrospinal fluid (CSF) cell count was prominently elevated in patients with acute NBD, but was normal in about 15% of those with CP NBD. The sensitivity and specificity of the CSF cell count for the diagnosis of acute NBD versus non-NBD were 97.4 and 97.0%, respectively (cut-off 6.2/mm3). The sensitivity and specificity of CSF interleukin (IL)-6 for the diagnosis of CP NBD versus the recovery phase of acute NBD were 86.7 and 94.7%, respectively (cut-off 16.55 pg/ml). The results indicate that elevation of the CSF cell count and CSF IL-6 and the presence of brainstem atrophy on MRI are useful for the diagnosis of NBD.

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Section: Discussionsupporting

confidence: 88%

Clinical characteristics of neuro-Behcet’s disease in Japan: a multicenter retrospective analysis

et al. 2011

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“…Moreover, in the patients who did not show elevations of CSF IL-8, the CSF IL-8 levels did not decrease following successful treatment. These results indicate that, among the proinflammatory cytokines, IL-6 plays the most important role in the pathogenesis of NB, as is consistent with the results of previous studies (7,8,19,20).…”

Section: Discussionsupporting

confidence: 82%

Changes in Biomarkers Focused on Differences in Disease Course or Treatment in Patients with Neuro-Behçet's Disease

Hirohata

Kikuchi

2012

Intern. Med.

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Objective Neurological manifestations of Behçet's disease (NB) are serious complications. However, their pathogenesis remains unclear. The current study examined the levels of proinflammatory cytokines, including IL-1β, IL-6, IL-8 and TNF-α, in cerebrospinal fluid (CSF). Methods CSF cytokines were measured using an enzyme-linked immunosorbent assay. CSF was obtained from 17 patients with acute NB, 19 patients with chronic progressive NB and 20 patients with noninflammatory neurological diseases, including cerebrovascular disease, cervical spondylosis and degenerative diseases. Results CSF total cell counts and polymorph nuclear leukocyte counts were significantly lower in the patients with chronic progressive NB than in those with acute NB. The CSF levels of IL-6 and IL-8 were markedly elevated in the NB patients compared with those measured in the control patients. There were no significant differences in the CSF levels of IL-6 and IL-8 between the patients with acute NB and those with chronic progressive NB. In contrast, there were no significant differences in the CSF levels of IL-1β and TNF-α among the control, acute NB and chronic progressive NB patients. Consistently, the CSF levels of IL-6 and IL-8 were significantly decreased following successful treatment in both acute NB and chronic progressive NB patients, whereas the CSF levels of IL-1β and TNF-α were not changed significantly. Of note, the CSF levels of IL-6 were significantly correlated with the CSF levels of IL-8 in the patients with acute NB (r =0.7647, p =0.0003) but not in the patients with chronic progressive NB (r =0.1343, p =0.5835). Conclusion These results indicate that CSF IL-6 and IL-8 play important roles in the pathogenesis of NB. However, the data also suggest that the mechanisms underlying the elevation of CSF IL-6 and IL-8 might be different in patients with acute NB and those with chronic progressive NB.

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“…Release of proinflammatory cytokines (IL-6, IL-1β, TNF-α) may trigger apoptotic cascades [23]. CSF IL-6 may be elevated in both ALS and NBD [24][25][26]. However, whether this is a cause or an effect is unclear.…”

Section: Discussionmentioning

confidence: 95%

Association of amyotrophic lateral sclerosis and Behcet’s disease: is there a relationship? A multi-national case series

et al. 2012

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Neurological involvement may be seen in 5-30% of the patients with Behcet's disease (BD). Occasionally, parenchymal neurological involvement in BD can present as a spinal cord syndrome. However, motor neuron disease-like presentation is extremely uncommon. Here we are reporting five patients (all male; median age, 38) fulfilling both International Study Group criteria for BD and El Escorial criteria for amyotrophic lateral sclerosis (ALS). These patients were identified by a questionnaire sent to the members of the Neuro-Behcet Study Group of the International Study Group for BD. Three out of five patients had only motor presentations. In two patients, sensory and urinary manifestations were present as well. Spinal cord MRIs were normal in all, and brain MRIs were normal in four patients; one patient had nonspecific white matter changes. Two patients passed away 1-3 years after diagnosis of ALS, and two patients were lost to follow-up 3 and 11 years after admission; one patient is still alive 3 years after onset. The patients that are presented here might represent a rare form of neurological involvement in BD as well as sole coincidence. Larger prospective series are needed to further answer this issue.

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CSF levels of cytokines in neuro-Behçet's disease

Cited by 58 publications

References 17 publications

Clinical characteristics of neuro-Behcet’s disease in Japan: a multicenter retrospective analysis

Clinical characteristics of neuro-Behcet’s disease in Japan: a multicenter retrospective analysis

Changes in Biomarkers Focused on Differences in Disease Course or Treatment in Patients with Neuro-Behçet's Disease

Association of amyotrophic lateral sclerosis and Behcet’s disease: is there a relationship? A multi-national case series

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