Changes in Biomarkers Focused on Differences in Disease Course or Treatment in Patients with Neuro-Behçet's Disease

Abstract

Objective Neurological manifestations of Behçet's disease (NB) are serious complications. However, their pathogenesis remains unclear. The current study examined the levels of proinflammatory cytokines, including IL-1β, IL-6, IL-8 and TNF-α, in cerebrospinal fluid (CSF). Methods CSF cytokines were measured using an enzyme-linked immunosorbent assay. CSF was obtained from 17 patients with acute NB, 19 patients with chronic progressive NB and 20 patients with noninflammatory neurological diseases, including cerebrovascular disease, cervical spondylosis and degenerative diseases. Results CSF total cell counts and polymorph nuclear leukocyte counts were significantly lower in the patients with chronic progressive NB than in those with acute NB. The CSF levels of IL-6 and IL-8 were markedly elevated in the NB patients compared with those measured in the control patients. There were no significant differences in the CSF levels of IL-6 and IL-8 between the patients with acute NB and those with chronic progressive NB. In contrast, there were no significant differences in the CSF levels of IL-1β and TNF-α among the control, acute NB and chronic progressive NB patients. Consistently, the CSF levels of IL-6 and IL-8 were significantly decreased following successful treatment in both acute NB and chronic progressive NB patients, whereas the CSF levels of IL-1β and TNF-α were not changed significantly. Of note, the CSF levels of IL-6 were significantly correlated with the CSF levels of IL-8 in the patients with acute NB (r =0.7647, p =0.0003) but not in the patients with chronic progressive NB (r =0.1343, p =0.5835). Conclusion These results indicate that CSF IL-6 and IL-8 play important roles in the pathogenesis of NB. However, the data also suggest that the mechanisms underlying the elevation of CSF IL-6 and IL-8 might be different in patients with acute NB and those with chronic progressive NB.

Infliximab therapy for intestinal, neurological, and vascular involvement in Behcet disease

“…[5] TNF-α production is elevated in the intestinal tissues of intestinal BD patients [6] and in peripheral blood cells of VBD patients, [7] while IL-6 concentrations are elevated in the cerebrospinal fluid (CSF) of NBD patients. [8] …”

Neuro‐behçet's disease in South Korea: clinical characteristics and treatment response

“…3,6,7 Acute NBD is defined as acute neurological symptoms with or without meningoencephalitis which is resolved by steroids or spontaneously. 3,6,7 Acute NBD is defined as acute neurological symptoms with or without meningoencephalitis which is resolved by steroids or spontaneously.…”

“…13,14 Recently, there have been reports that increases in the levels of CSF cytokines, such as interleukin (IL)-6 6,15,[16][17]17 are useful in diagnosing NBD and that these levels correlate with relapse of the disease. Only two patients showed meningeal involvement upon MRI examination.…”

New approaches to divorce with children: A problem of public health

“…IL-6 stimulates the inflammatory and auto-immune processes in many diseases such as diabetes, atherosclerosis, depression, Alzheimer’s disease, systemic lupus erythematosus, multiple myeloma, prostate cancer, Behçet’s disease, and rheumatoid arthritis (Gadó et al, 2000; Hirohata and Kikuchi, 2012; Nishimoto, 2006; Smith et al, 2001; Tackey et al, 2004). …”