Crystallography Aided by Atomic Core‐Level Binding Energies: Proton Transfer versus Hydrogen Bonding in Organic Crystal Structures

Stevens, Joanna S.; Byard, Stephen J.; Seaton, Colin C.; Sadiq, Ghazala; Davey, Roger J.; Schroeder, Sven L. M.

doi:10.1002/anie.201103981

Cited by 39 publications

(55 citation statements)

References 42 publications

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“…A significant increase in nitrogen results from attachment of the peptide (Table ), with increased intensity at 400.1 eV (Fig. ) representative of the additional amide peptide linkages and the arginine side‐chain, while the slight asymmetry to high E B values reflects the presence of NH 3 + at the free arginine N‐terminus (Table ) . Increased intensity is also observed for amide‐specific binding energies in the C1s and O1s spectra (Fig.…”

Section: Resultsmentioning

confidence: 92%

Immobilisation of cell‐binding peptides on poly‐ε‐caprolactone (PCL) films: A comparative XPS study of two chemical surface functionalisation methods

Stevens

Luca

Downes

et al. 2014

Surface & Interface Analysis

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Section: Resultsmentioning

confidence: 92%

Immobilisation of cell‐binding peptides on poly‐ε‐caprolactone (PCL) films: A comparative XPS study of two chemical surface functionalisation methods

Stevens

Luca

Downes

et al. 2014

Surface & Interface Analysis

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“…A shoulder peak for N 1s is located at 401.0 eV due to protonation of NH 3 , which can be used to identify the formation of the ammonium (NH 4 + ) salt. 40 The reducing binding energies at 513.5 and 533.2 eV can be ascribed to the O atoms in —C=O and —COOH, respectively (Figure 3d). The high-resolution O 1s spectrum observed at 532.3 eV is resolved into two characteristic peaks for —C=O in H bond and —COO – in the ammonium salt.…”

Section: Resultsmentioning

confidence: 97%

Surface Pore Engineering of Covalent Organic Frameworks for Ammonia Capture through Synergistic Multivariate and Open Metal Site Approaches

et al. 2018

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Ammonia (NH3) is a commonly used industrial gas, but its corrosiveness and toxicity are hazardous to human health. Although many adsorbents have been investigated for NH3 sorption, limited ammonia uptake remains an urgent issue yet to be solved. In this article, a series of multivariate covalent organic frameworks (COFs) are explored which are densely functionalized with various active groups, such as —N—H, —C=O, and carboxyl group. Then, a metal ion (Ca2+, Mn2+, and Sr2+) is integrated into the carboxylated structure achieving the first case of an open metal site in COF architecture. X-ray photoelectron spectroscopy reveals conclusive evidence for the multiple binding interactions with ammonia in the modified COF materials. Infrared spectroscopy indicates a general trend of binding capability from weak to strong along with —N—H, —C=O, carboxyl group, and metal ion. Through the synergistic multivariate and open metal site, the COF materials show excellent adsorption capacities (14.3 and 19.8 mmol g–1 at 298 and 283 K, respectively) and isosteric heat (Qst) of 91.2 kJ mol–1 for ammonia molecules. This novel approach enables the development of tailor-made porous materials with tunable pore-engineered surface for ammonia uptake.

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“…4, Table I). A significant increase in nitrogen resulted from attachment of the peptide (Table I), with photoemission at 400.1 eV representative of the additional amide peptide linkages and the arginine side‐chain, while the slight asymmetry to high E B values reflected the presence of NH 3 + at the free arginine N‐terminus 22. The sulfur photoemission around 168.5 eV (Fig.…”

Section: Resultsmentioning

confidence: 99%

Immobilization of cell‐binding peptides on poly‐ε‐caprolactone film surface to biomimic the peripheral nervous system

Luca

Stevens

Schroeder

et al. 2012

J Biomedical Materials Res

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Cell-material interactions are crucial for cell adhesion and proliferation on biomaterial surfaces. Immobilization of biomolecules leads to the formation of biomimetic substrates, improving cell response. We introduced RGD (Arg-Gly-Asp) sequences on poly-ε-caprolactone (PCL) film surfaces using thiol chemistry to enhance Schwann cell (SC) response. XPS elemental analysis indicated an estimate of 2-3% peptide functionalization on the PCL surface, comparable with carbodiimide chemistry. Contact angle was not remarkably reduced; hence, cell response was only affected by chemical cues on the film surface. Adhesion and proliferation of Schwann cells were enhanced after PCL modification. Particularly, RGD immobilization increased cell attachment up to 40% after 6 h of culture. It was demonstrated that SC morphology changed from round to very elongated shape when surface modification was carried out, with an increase in the length of cellular processes up to 50% after 5 days of culture. Finally RGD immobilization triggered the formation of focal adhesion related to higher cell spreading. In summary, this study provides a method for immobilization of biomolecules on PCL films to be used in peripheral nerve repair, as demonstrated by the enhanced response of Schwann cells.

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Crystallography Aided by Atomic Core‐Level Binding Energies: Proton Transfer versus Hydrogen Bonding in Organic Crystal Structures

Cited by 39 publications

References 42 publications

Immobilisation of cell‐binding peptides on poly‐ε‐caprolactone (PCL) films: A comparative XPS study of two chemical surface functionalisation methods

Immobilisation of cell‐binding peptides on poly‐ε‐caprolactone (PCL) films: A comparative XPS study of two chemical surface functionalisation methods

Surface Pore Engineering of Covalent Organic Frameworks for Ammonia Capture through Synergistic Multivariate and Open Metal Site Approaches

Immobilization of cell‐binding peptides on poly‐ε‐caprolactone film surface to biomimic the peripheral nervous system

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