Crystallization of Transfer RNA

Clark, Brian F. C.; Doctor, Bhupendra P.; Holmes, Kenneth C.; Klug, A.; Marcker, Kjeld A.; Morris, Shirley J.; Paradies, Hasko H.

doi:10.1038/2191222a0

Cited by 66 publications

(7 citation statements)

References 9 publications

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“…Transfer RNA was the first, and is at present the only, nucleic acid to form single crystals large enough for an X-ray diffraction study. The flurry of activity that ensued in the nine years following the first crystallization (Cramer et al 1968;Fresco, Blake & Langridge, 1968;Clark et al 1968;Hampel et al 1968;Kim & Rich, 1968) has resulted in the production of four sets of atomic co-ordinates (Sussman & Kim, 1976 a;Stout et al 1976;Quigley et al 1975;Ladner et al 1975) all for yeast phenylalanine tRNA. Several reviews have been written which trace both the history and the electron density maps of tRNA (Rich & Raj-Bhandary, 1976;Kim, 1976Kim, , 1977Sussman & Kim, 1976&;Arnott, 1971;Sigler, 1975).…”

Section: Molecules (A) Transfer Rnamentioning

confidence: 99%

RNA structure

Kallenbach

Berman

1977

Quart. Rev. Biophys.

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This review is concerned primarily with the physical structure and changes in the structure of RNA molecules. It will be evident that we have not attempted comprehensive coverage of what amounts to a vast literature. We have tried to stay away from particular areas that have been recently reviewed elsewhere. Citations to and information from them are included, however, so that access to the literature is available. Much of what we treat in depth deals with the crystal structures and solution behaviour of model RNA compounds, including synthetic polymers and molecular fragments such as dinucleoside phosphates. Sequence data on natural RNA are cited, but not in detail. Similarly, apart from tRNA, natural RNAs the structural determinations of which are presently not so far advanced, are not dwelt upon. We have tried to present in detail the available structural data with scaled drawings that permit facile comparisons of molecular geometries.

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Section: Molecules (A) Transfer Rnamentioning

confidence: 99%

RNA structure

Kallenbach

Berman

1977

Quart. Rev. Biophys.

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“…Hopefully, a complete account of the structure of a tRNA in crystalline form will be approachable soon ; microcrystals of E. coli tRNA met have been obtained and X-ray powder diagrams made (240), and single, large crystals of tRNA~* t (241,242) and tRNA~h° (yeast) (242) are under study by X-ray diffraction.…”

Section: Am~noacyl-trna Syntitetasesmentioning

confidence: 99%

Recognition of Nucleotide Sequences

Yarus¹

1969

Annu. Rev. Biochem.

108

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“…Many attempts to determine the secondary (85,275) and tertiary (202) structure of tRNA have been made (114), so far providing no really convincing evidence for any model. Recent progress in the crystallization of tRNA from E. coli and yeast (69,78,113,146,180) has encouraged the hope that the tertiary structure of tRNA will be determined by X-ray crystallography. Crystallization of the complex of tRNA and its cognate AA-tRNA synthetase may prove even more illuminating.…”

Section: Genetics Of Synthetasesmentioning

confidence: 99%