2008
DOI: 10.1107/s1744309108006921
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Crystallization and preliminary X-ray diffraction studies of Seneca Valley Virus-001, a new member of thePicornaviridaefamily

Abstract: Seneca Valley Virus-001 (SVV-001) is a newly found species in the Picornaviridae family. SVV-001 is the first naturally occurring nonpathogenic picornavirus observed to mediate selective cytotoxicity towards tumor cells with neuroendocrine cancer features. The nonsegmented (+)ssRNA genome of SVV-001 shares closest sequence similarity to the genomes of the members of the Cardiovirus genus. However, based on the distinct characteristics of the genome organization and other biochemical properties, it has been sug… Show more

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Cited by 27 publications
(14 citation statements)
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“…The genome of SVA is approximately 7.2 kb in length, which contains a single open reading frame (ORF). The ORF encoding a polyprotein of 2181 amino acids, consists of 12 proteins (Lpro, VP1, VP2, VP3, VP4, 2A, 2B, 2C, 3A, 3B, 3C, and 3D) [1][2][3]. Structural biology analysis revealed that the B-cell epitopes of SVA mainly exist in VP2 and VP3 proteins (in our laboratory).…”
Section: Introductionmentioning
confidence: 66%
“…The genome of SVA is approximately 7.2 kb in length, which contains a single open reading frame (ORF). The ORF encoding a polyprotein of 2181 amino acids, consists of 12 proteins (Lpro, VP1, VP2, VP3, VP4, 2A, 2B, 2C, 3A, 3B, 3C, and 3D) [1][2][3]. Structural biology analysis revealed that the B-cell epitopes of SVA mainly exist in VP2 and VP3 proteins (in our laboratory).…”
Section: Introductionmentioning
confidence: 66%
“…Seneca Valley Virus (SVV-001) is a replication-competent oncolytic picornavirus, discovered as a contaminant of a laboratory adenovirus preparation (47). The replicative potential of SVV-001 has been studied in a large number of human cancer lines.…”
Section: Introductionmentioning
confidence: 99%
“…The SVV-001 was crystallized in a R3 space group with unit cell dimensions a = b =311.5Å, c =1526.4Å, α=β=90°, γ=120° and it’s structure was determined at 2.3Å resolution by molecular replacement using MEV capsid as the model (Venkataraman et al, 2008). The unit cell of SVV-001 is unusual because of a long c -axis (1526Å) that is nearly 4.9 times the lengths of a or b axis (311Å) and hence accommodates six virus particles.…”
Section: Methodsmentioning
confidence: 99%