In the present work, we report the growth of fully untwinned high-quality a-axis-oriented YBa 2 Cu 3 O 7−δ films on (100) SrLaGaO 4 substrates by using PrBa 2 Cu 3 O 7−δ as a buffer layer. We also fabricated nanowires at different angles γ with respect to the [0,1,0] direction of the substrate and studied the in-plane anisotropy of the critical current density, which we explained by considering the anisotropy in the coherence length ξ and London penetration depth λ L . Finally, half-integer Shapiro-like steps measured in slightly underdoped c-axis oriented (γ = 90• ) nanowires point towards a different transport regime, which could shed light on intriguing issues of high-critical-temperature superconductors.