Crystal structures of Toxoplasma gondii pterin-4a-carbinolamine dehydratase and comparisons with mammalian and parasite orthologues

Cameron, Scott; Fyffe, S.A.; Goldie, Simon; Hunter, William N.

doi:10.1016/j.molbiopara.2007.12.002

Cited by 5 publications

(1 citation statement)

References 24 publications

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“…The pterin-4a-carbinolamine dehydratase enzyme is encoded in the T. gondii genome and showed great similarity to the human enzyme. This important enzyme is involved in the recycling of biopterin, and its secretion may result in the supply of biopterin from the host. , Intriguingly, guanosine-5′-triphosphate cyclohydrolase, which is upregulated in T. gondii -infected cells, plays a role in biopterin synthesis. , The parasite uses these genes and their products in their metabolism and activities.…”

Section: Molecular Aspects and Gene Expression Changes During Toxopla...mentioning

confidence: 99%

Toxoplasmosis and Psychiatric and Neurological Disorders: A Step toward Understanding Parasite Pathogenesis

Abo‐Al‐Ela¹

2019

ACS Chem. Neurosci.

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Toxoplasmosis, a disease that disrupts fetal brain development and severely affects the host’s brain, has been linked to many behavioral and neurological disorders. There is growing interest in how a single-celled neurotropic parasite, Toxoplasma gondii, can control or change the behavior of the host as well as how it dominates the host’s neurons. Secrets beyond these could be answered by decoding the Toxoplasma gondii genome, unravelling the function of genomic sequences, and exploring epigenetics and mRNAs alterations, as well as the postulated mechanisms contributing to various neurological and psychiatric symptoms caused by this parasite. Substantial efforts have been made to elucidate the action of T. gondii on host immunity and the biology of its infection. However, the available studies on the molecular aspects of toxoplasmosis that affect central nervous system (CNS) circuits remain limited, and much research is still needed on this interesting topic. In my opinion, this parasite is a gift for studying the biology of the nervous system and related diseases. We should utilize the unique features of Toxoplasma, such as its abilities to modulate brain physiology, for neurological studies or as a possible tool or approach to cure neurological disease.

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Section: Molecular Aspects and Gene Expression Changes During Toxopla...mentioning

confidence: 99%

Toxoplasmosis and Psychiatric and Neurological Disorders: A Step toward Understanding Parasite Pathogenesis

Abo‐Al‐Ela¹

2019

ACS Chem. Neurosci.

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Comparative proteomic analysis of seedling leaves of cold-tolerant and -sensitive spring soybean cultivars

et al. 2014

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Cold stress adversely affects the growth and development of seedling of spring soybean. Revealing responses in seedling to cold stress at proteomic level will help us to breed cold-tolerant spring soybean cultivars. In this study, to understand the responses, a proteomic analysis on the leaves of seedlings of one cold-tolerant soybean cultivar and one cold-sensitive soybean cultivar at 5°C for different times (12 and 24 h) was performed, with some proteomic results being further validated by physiological and biochemical analysis. Our results showed that 57 protein spots were found to be significantly changed in abundance and identified by MALDI-TOF/TOF MS. All the identified proteins were found to be involved in 13 metabolic pathways and cellular processes, including photosynthesis, protein folding and assembly, cell rescue and defense, cytoskeletal proteins, transcription and translation regulation, amino acid and nitrogen metabolism, protein degradation, storage proteins, signal transduction, carbohydrate metabolism, lipid metabolism, energy metabolism, and unknown. Based on the majority of the identified cold-responsive proteins, the effect of cold stress on seedling leaves of the two spring soybean cultivars was discussed. The reason that soybean cv. Guliqing is more cold-tolerant than soybean cv. Nannong 513 was due to its more protein, lipid and polyamine biosynthesis, more effective sulfur-containing metabolite recycling, and higher photosynthetic rate, as well as less ROS production and lower protein proteolysis and energy depletion under cold stress. Such a result will provide more insights into cold stress responses and for further dissection of cold tolerance mechanisms in spring soybean.

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Leishmania–macrophage interactions: Insights into the redox biology

Assche

Deschacht

Luz

et al. 2011

Free Radical Biology and Medicine

195

130

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Crystal structures of Toxoplasma gondii pterin-4a-carbinolamine dehydratase and comparisons with mammalian and parasite orthologues

Cited by 5 publications

References 24 publications

Toxoplasmosis and Psychiatric and Neurological Disorders: A Step toward Understanding Parasite Pathogenesis

Toxoplasmosis and Psychiatric and Neurological Disorders: A Step toward Understanding Parasite Pathogenesis

Comparative proteomic analysis of seedling leaves of cold-tolerant and -sensitive spring soybean cultivars

Leishmania–macrophage interactions: Insights into the redox biology

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