Crystal structure, vibrational spectroscopic characterization, thermal behavior and antifungal activity of a novel coordination polymer of indole‑3‑carboxylic acid with cobalt(II) and a comparison with the isostructural Zn(II) complex

Szmigiel, Ksenia; Nentwig, Markus; Barczyńska-Felusiak, Renata; Morzyk-Ociepa, Barbara

doi:10.1016/j.inoche.2018.09.009

Cited by 15 publications

(1 citation statement)

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“…It is often difficult to predict the bioactivity of CPs owing to the influence of many factors, such as the structure of the CPs, metal ions, ligands, and so on (Han et al, 2008;Hosseinabadi et al, 2016). The effect of metal cations is very important for the biological properties of CPs and this effect is often manifested when the polymers are isostructural (Szmigiel et al, 2018;Beheshti et al, 2017). Isostructural CPs are beneficial for us to study the role of metal ions in the bioactivity of CPs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure and biological properties of Cd and Zn coordination polymers based on a flexible tripodal ligand

Wang

Ling

et al. 2019

Acta Crystallogr C

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Two new coordination polymers, namely poly[[hexathiocyanatotetrakis{μ3‐2,4,6‐trimethyl‐1,3,5‐tris[(triazol‐1‐yl)methyl]benzene}tricadmium(II)] 3.5‐hydrate], {[Cd3(SCN)6(C18H21N9)4]·3.5H2O}n (1), and poly[[hexathiocyanatotetrakis{μ3‐2,4,6‐trimethyl‐1,3,5‐tris[(triazol‐1‐yl)methyl]benzene}trizinc(II)] 3.5‐hydrate], {[Zn3(SCN)6(C18H21N9)4]·3.5H2O}n (2), have been synthesized under hydrothermal conditions and characterized by elemental analysis, IR spectroscopy and single‐crystal X‐ray diffraction analysis. From the X‐ray analysis, it is noteworthy that polymers 1 and 2 are isostructural, with their three‐dimensional structures composed of three kinds of four‐connection metal ions and two kinds of three‐connection 2,4,6‐trimethyl‐1,3,5‐tris[(triazol‐1‐yl)methyl]benzene (TTTMB) ligand nodes. Each metal ion is six‐coordinated in a slightly distorted octahedral geometry. The antioxidant activity against DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) and the antidiabetic activity against α‐amylase of the synthesized compounds were evaluated in vitro. The results of the DPPH free‐radical scavenging assay showed that polymers 1 and 2 exhibited strong antioxidant effects, with IC50 values of 3.81 and 2.56 mg ml−1, respectively. The IC50 value in the antidiabetic studies of polymer 1 was 3.94 mg ml−1, while polymer 2 exhibited no antidiabetic activity. Polymers 1 and 2 revealed different inhibitory activities on DPPH and α‐amylase, which indicated that the metal ions play important roles in the biological activity of coordination polymers. In addition, the solid‐state photoluminescence properties and thermal stability of 1 and 2 have been investigated.

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