2002
DOI: 10.1006/jmbi.2001.5296
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Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes

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Cited by 126 publications
(88 citation statements)
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“…Recombinant human BAFF was produced as described (39). BAFF and recombinant human IL-4 (R&D Systems) were used at optimal concentrations of 50 and 5 ng/ml, respectively.…”
Section: Cytokines and Additional Culture Reagentsmentioning
confidence: 99%
“…Recombinant human BAFF was produced as described (39). BAFF and recombinant human IL-4 (R&D Systems) were used at optimal concentrations of 50 and 5 ng/ml, respectively.…”
Section: Cytokines and Additional Culture Reagentsmentioning
confidence: 99%
“…Like most members of the TNF family, the extracellular domain of TALL-1 can be cleaved to form a soluble cytokine (2). Crystal structure studies suggest that soluble TALL-1 (sTALL-1) 3 contains an unique "flap" region that is important for its virus-like assembly, receptor binding, and biological activities (7)(8)(9).…”
Section: Tnfr-associatedmentioning
confidence: 99%
“…[7][8][9] Members of the TNF family usually assemble as trimers, 10 but soluble BAFF was crystallized both as a trimer and as a virus-like structure resulting from the ordered assembly of 20 trimers through an unusually long loop of BAFF between ␤-sheets D and E (DE loop). 11,12 Although the physiologic relevance of BAFF 60-mer has not been studied, recent work showed that BAFF 60-mer was also produced by cells expressing BAFF endogenously and that the 60-mer was moderately more potent than the 3-mer at costimulating BCR-induced thymidine uptake in primary B cells. 13 APRIL, a close homolog of BAFF, can also costimulate B cells but requires oligomerization to do so.…”
Section: Introductionmentioning
confidence: 99%