Crystal structure of 3-(2-amino-1,3-selenazol-4-yl)-2H-chromen-2-one – dimethylformamide (1/1), C₁₅H₁₅N₃O₃Se

Abstract

The asymmetric unit of the title crystal structure is shown in the figure. Tables 1 and 2 contain details of the measurement method and a list of the atoms including atomic coordinates and displacement parameters. Source of material3-(2-Bromo-acetyl)-chromen-2-one (0.05 mol) and selenourea (0.05 mol) were dissolved in 5 mL methanol-water (1 : 1) contaning 0.08 g NaF. The mixture was stirred at room temperature for 30 minutes. After the completion of the reaction, water (10 mL) was added to the reaction mixture and extracted with ethyl acetate. The organic layer was dried over anhydrous Na 2 SO4. The solvent was evaporated under reduced pressure and the resulting product was further purified by column chromatography (hexane:ethyl acetate, 7 : 3) [3,4]. Single crystals suitable for X-ray structure analysis were obtained by dissolving the compound in methanol and DMF. Then, the solvents were concentrated using a rotary evaporator. The mixture was cooled to room temperature and allowed to rest overnight. The title compound formed reddish brown parallelepipeds in a yield of 50%. Experimental detailsThe C-H atoms were constrained to an ideal geometry, with C-H distances of 0.93-0.96 Å. The U iso values of the hydrogen

Synthesis, Antioxidant, Anticholinesterase Activities and Molecular Docking Studies of coumaryl 1,3-selenazoles Derivatives

“…To the best of our knowledge, there is a limited study on the synthesis and biological activities of coumaryl 1,3 -selenazole structures. This is a continuation of previous work on the synthesis of coumaryl 1,3 -selenazole derivatives and its biological activities and the crystal structure of a coumaryl 1,3-selenazole [23,26]. Scheme 1.…”