Crystal structure, antitumor activities and DNA-binding properties of the La(III) complex with Phthalazin-1(2H)-one prepared by a novel route

Study on DNA-binding properties and cytotoxicity in L1210 of La(III) complex with PMBP-isonicotinoyl hydrazone

“…Although the mechanism which the La-complex selectively affects L 1210 is still unclear, its special structure is vital. Lots of other heterocyclic Schiff's bases Lanthanum complexes often appear similar biological and pharmaceutical activities, for example, Lanthanum complexes with both 4 0 ,5,7-trihydroxy-flavanoe benzoyl hydrazone [11] and phthalazin-1(2H)-one [12] have considerable cytotoxic activity against two kinds of tumor cells (human leukemia HL-60 and lung adenocarinoma A-549), the two complexes can strongly bind with calf thymus DNA, the intrinsic binding constants of their complexes with DNA are 1.83 · 10 7 and 1.4 · 10 7 M À1 , respectively. This is an interesting phenomenon, which also show that the interaction between the complex molecules and DNA can cause DNA damage in tumor cells, blocking the division of tumor cells and resulting in the cell death [8,9].…”

Crystal structures, antioxidation and DNA binding properties of Eu(III) complexes with Schiff-base ligands derived from 8-hydroxyquinoline-2-carboxyaldehyde and three aroylhydrazines

“…After refluxing for 30 min, triethylamine (0.020 g, 0.2 mmol) was added into the reaction mixtures dropwise to deprotonate the phenolic hydroxyl substituent of 8-hydroxyquinolinato unit. Then, the mixtures were refluxed and stirred continuously for 8 h. After cooling to room temperature, the precipitate was centrifugalized, washed adequately with hot methanol and dried in vacuum over 48 …”

“…In fact, some groove binders of Hoechst 33,258 family can also present red shifts or even blue shifts of absorption bands when they bind to DNA helix through groove binding modes, especially for multiple binders [45,46]. After all, hydrodynamic measurements that are sensitive to length change of DNA (i.e., viscosity and sedimentation) are regarded as the least ambiguous and the most critical criterions for binding modes in solution in absence of crystallographic structural data [47,48].…”

Crystal structures, antioxidation and DNA binding properties of Yb(III) complexes with Schiff-base ligands derived from 8-hydroxyquinoline-2-carbaldehyde and four aroylhydrazines

“…In fact, some groove binders of Hoechst 33,258 family can also present red shifts or even blue shifts of absorption bands when they bind to DNA helix by groove binding modes, especially for multiple binders (Behrens et al 2001;Frau et al 1997). After all, hydrodynamic measurements that are sensitive to length change of DNA (i.e., viscosity and sedimentation) are regarded as the least ambiguous and the most critical criterions for binding modes in solution in absence of crystallographic structural data (Sigman et al 1993;Wang et al 2005). …”