Crystal habit and tableting behavior

Rasenack, Norbert; Müller, Bernd W.

doi:10.1016/s0378-5173(02)00296-x

Cited by 153 publications

(99 citation statements)

References 8 publications

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“…These correlations were significant (p < 0.05). Such linear relationship between log% survival of microorganisms and compression pressure has been reported for other pharmaceutical preparations in previous works (Rasenack, Muller, 2002;Roberts, Rowe, 1996;Fichtner, 2007;Bashaiwoldu et al, 2004;Ayorinde et al, 2005). DCS, the most plastic formulation as evidenced by the lowest values of both P y and P k , was found to exhibit the highest reduction in viability of the microbial contaminant.…”

Section: Tensile Strength (T) Of Tabletssupporting

confidence: 81%

“…The deformation mechanism of a specific particle is affected mainly by the molecular and crystal structure of the material (Rasenack, Muller, 2002). Hard, brittle materials which have greater shear strength than tensile strength tend to fragment more easily than soft materials, which have lower shear strength than tensile strength.…”

Section: Mean Yield Pressure (P Y ) and P Kmentioning

confidence: 99%

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Influence of binder type and process parameters on the compression properties and microbial survival in diclofenac tablet formulations

Ayorinde

Itiola

Odeku

et al. 2011

Braz. J. Pharm. Sci.

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The influence of binder type and process parameters on the compression properties and microbial survival in diclofenac tablet formulations were studied using a novel gum from Albizia zygia. Tablets were produced from diclofenac formulations containing corn starch, lactose and dicalcium phosphate. Formulations were analyzed using the Heckel and Kawakita plots. Determination of microbial viability in the formulations was done on the compressed tablets of both contaminated and uncontaminated tablets prepared from formulations. Direct compression imparted a higher plasticity on the materials than the wet granulation method. Tablets produced by wet granulation presented with a higher crushing strength than those produced by the direct compression method. Significantly higher microbial survival (p< 0.05) was obtained in formulations prepared by direct compression. The percent survival of Bacillus subtilis spores decreased with increase in binder concentration. The study showed that Albizia gum is capable of imparting higher plasticity on materials and exhibited a higher reduction of microbial contaminant in the formulations. The direct compression method produced tablets of reduced viability of microbial contaminant.Uniterms: Tablets/production. Tablets/microbial analysis. Direct compression/tablets production. Wet granulation/tablets production. Tablets/microbial contamination. Microbial survival/in tablets. Albizia gum/use/tablets production.A influência do tipo de ligante e os parâmetros do processo de propriedades de compressão e sobrevivência microbiana em comprimidos de diclofenaco foram estudados utilizando uma nova goma de Albizia zygia. Os comprimidos foram produzidos a partir de formulações de diclofenaco contendo amido de milho, lactose e fosfato bicálcico. As formulações foram analisadas usando os gráficos de Heckel e Kawakita. A determinação da viabilidade microbiana nas formulações foi feita nos comprimidos contaminados e não contaminados preparados a partir de formulações. A compressão direta confere maior plasticidade dos materiais do que o método de granulação úmida. Comprimidos produzidos por granulação úmida apresentaram maior força de esmagamento do que aqueles produzidos pelo método de compressão direta. Observou-se sobrevivência significativamente maior (p<0,05) em formulações preparadas por compressão direta. A sobrevivência percentual dos esporos de Bacillus subtilis diminuiu com o aumento da concentração do agregante. O estudo mostrou que a goma de Albizia é capaz de conferir maior plasticidade aos materiais e apresentou maior redução da contaminação microbiana nas formulações. O método de compressão direta produziu comprimidos com viabilidade reduzida de contaminantes microbianos.

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Section: Tensile Strength (T) Of Tabletssupporting

confidence: 81%

Section: Mean Yield Pressure (P Y ) and P Kmentioning

confidence: 99%

Influence of binder type and process parameters on the compression properties and microbial survival in diclofenac tablet formulations

Ayorinde

Itiola

Odeku

et al. 2011

Braz. J. Pharm. Sci.

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“…To overcome this problem many workers have attempted to improve properties through suitable particle design techniques. [45] Ultrasound (US) was introduced in the traditional process of pharmaceutical technology of few years ago. For instance, several workers reported US assisted compaction and US spray congealing of variety of systems where physical modification of structure of drug or excipients was done to improve drug release and compaction properties of drug.…”

Section: Melt Sonocrystallizationmentioning

confidence: 99%

A Review: Meltsonocrystallization Technique Used for Improvement of Solubility

Sardar¹

2017

WJPPS

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Melt sonocrystallization method have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. It is a novel particle engineering technique to enhance dissolution of hydrophobic drugs that is having less water solubility and to study its effect on crystal properties of drug. It forms agglomerates with number of shallow circular pits on the surface leads to increase solubility by improving its shape from crystalline to amorphous that is obtain circular shape. Melt sonocrystallization process was developed for poorly soluble drugs in which these poorly soluble drugs melt was poured in deionized water maintained at 60 0 C and simultaneously subjected to ultrasonic energy.The agglomerates obtained after solidification of dispersed droplets were separated by filtration and dried at room temperature. Hence this review gives valuable information about on melt-sonocrystallization shows that there is increase in solubility of poorly water soluble drugs.

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“…Though a single internal structure with different external morphologies often exists for the particular API, vice versa however is rarely evident. Nevertheless, the change in external and internal structures of the API within dosage form itself should affect not only the chemical and physical stabilities but also the performance of the dosage forms which includes dissolution, flowability, tableting, and syringeability (2)(3)(4). Since there is no single reliable method that existed to be able to legally secure all possible drug forms, it becomes therefore necessary for both innovator and generic drug companies to make every effort to find new and efficient (in terms of time and/or resources) screening methods.…”

Section: Introductionmentioning

confidence: 99%

Studies on Aspirin Crystals Generated by a Modified Vapor Diffusion Method

et al. 2015

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Abstract. The objectives of the current investigation were (1) to study the influence of selected two different non-solvents (diethylether and dichloromethane) on the drug crystal formation of a model drug, aspirin (ASP-I) by the modified vapor diffusion method and (2) to characterize and compare the generated crystals (ASP-II and ASP-III) using different analytical techniques with that of unprocessed ASP-I. When compared to the classical vapor diffusion method which consumes about 15 days to generate drug crystals, the modified method needs only 12 h to get the same. Fourier transform-infrared spectroscopy (FT-IR) reveals that the internal structures of ASP-II and ASP-III crystals were identical when compared with ASP-I. Although the drug crystals showed a close similarity in X-ray diffraction patterns, the difference in the relative intensities of some of the diffraction peaks (especially at 2θ values of around 7.7 and 15.5) could be attributed to the crystal habit or crystal size modification. Similarly, the differential scanning calorimetry (DSC) study speculates that only the crystal habit modifications might occur but without involving any change in internal structure of the generated drug polymorphic form I. This is further substantiated from the scanning electron microscopy (SEM) pictures that indicated the formation of platy shape for the ASP-II crystals and needle shape for the ASP-III crystals. In addition, the observed slow dissolution of ASP crystals should indicate polymorph form I formation. Thus, the modified vapor diffusion method could routinely be used to screen and legally secure all possible forms of other drug entities too.

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Crystal habit and tableting behavior

Cited by 153 publications

References 8 publications

Influence of binder type and process parameters on the compression properties and microbial survival in diclofenac tablet formulations

Influence of binder type and process parameters on the compression properties and microbial survival in diclofenac tablet formulations

A Review: Meltsonocrystallization Technique Used for Improvement of Solubility

Studies on Aspirin Crystals Generated by a Modified Vapor Diffusion Method

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