Crystal architectures of copper and zinc metal complexes containing 2-thiophenepropionate and 1,2-bis(4-pyridyl)ethane building blocks

Souza, Nelson Luis G. Dias de; Garcia, Humberto C.; Souza, Márcia Cristina de; Fernandes, Ana Luisa do Amaral; Pereira, Giselle Carvalho; Diniz, Renata; Oliveira, Luiz Fernando Cappa de

doi:10.1016/j.molstruc.2014.12.034

Cited by 6 publications

(2 citation statements)

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“…Also, these auxiliary ligands provide a hydrophobic microenvironment with various interplanar distances to govern the flexibility of the nucleotides. Importantly, they can prevent the nonenzymatic hydrolysis of nucleotide phosphate groups and increase the extent of nucleotide complex crystallization. , …”

Section: Resultsmentioning

confidence: 99%

“…Importantly, they can prevent the nonenzymatic hydrolysis of nucleotide phosphate groups and increase the extent of nucleotide complex crystallization. 32,33 Here, we are extremely concerned about dTMP, a nucleotide underexplored in this field, which has a large methyl group, fixing the alignment/orientation of pyrimidine bases using moderate π•••π stacking interactions. The auxiliary ligands are selected bpa and 4,4′-bipy, in which the former is a more flexible ligand than the latter (Scheme 1).…”

Section: Resultsmentioning

confidence: 99%

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Solidarity of the Coordination Helix and Water Helix in the Nucleotide Coordination Polymer

Zohaib,

Saqlain,

Khan

et al. 2024

Crystal Growth & Design

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Helix structure is a very important and fundamental structural feature of DNA and other biomaterials and is also one of the origins of chirality. Diversiform helix structures have been designed and constructed to understand the mechanism of helix formation. One of the challenges in this field is rationalizing single-stranded DNA and water helix. The possibility of water helix formation preceding the base pairing in DNA is an intriguing prospect. In this work, three coordination polymers based on the nucleotide dTMP have been designed and studied. Their single-crystal structures revealed that complexes 1 and 3 are 1D coordination polymers while complex 2 is a 2D coordination polymer. Complexes 1 and 2 are the coordination helixes. Importantly, the water helixes are enclosed in them. Both P and M water helixes exist in complex 1; only the M-water helix is in complex 2. It is worth noting that complex 3 exhibits the entanglement of coordination helixes and water helixes and then presents a pseudowater helix. The solidarity of the coordination helix and water helix in the crystal lattice has been investigated based on crystallography analysis. The building synthons limit the orientation of the nucleobase and lack adequate stereospace to confine the guest water molecules. A new type of nucleobase pairing, thymine−thymine, named T-motif, has been observed for the first time. The inherent and supramolecular chirality of these complexes have been discussed according to CD spectra in both solution and crystallized solid states. The water helix in complex 2 exhibits characteristic outcomes in the CD spectrum. The research results contribute to exploring and understanding the DNA structure and properties and the mechanism of helix formation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%