Development of medical drugs: Synthesis and in vitro bio-evaluations of nanomedicinal zinc–penicillins polymeric hydrogel membranes for wound skin dressing by new chemical technology

Refat, Moamen S.; Elsabawy, Khaled M.; Alhadhrami, A.; Almalki, Abdulraheem S. A.; El‐Sayed, Mohamed Y.; Hassan, Reham F.

doi:10.1016/j.molliq.2018.01.187

Cited by 18 publications

(10 citation statements)

References 36 publications

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“…So far, antimicrobial drugs remain the preferred strategy for clinical treatment of infected wound, and a large number of drugs have been reported to be encapsulated into hydrogels for preparing antimicrobial wound dressing, including antibiotics like amoxicillin, , ampicillin, tetracycline, − doxycycline, ,, gentamicin, , ciprofloxacin, − moxifloxacin, , chloramphenicol, sulfadiazine, linezolid and some other antibacterial drugs such as povidone-iodine, chlorhexidine acetate, ,, triclosan, simvastatin, and salicylate …”

Section: Advanced Functions In Hydrogel Wound Dressingsmentioning

confidence: 99%

“…After Ag, zinc is the most widely studied metal particle used in antibacterial wound dressings. Kumar et al ., respectively, applied zinc oxide in CS and chitin to obtain a series of freeze-dried hydrogels with antibacterial properties. , Then, Ag/Ag@AgCl/ZnO hybrid nanostructures, Zn-penicillin complex, ([Zn(pin–G)(Cl)]·6H 2 O), zinc oxide impregnated mesoporous silica (ZnO-MCM-41), and zinc oxide quantum dots (ZnO QDs)-modified thin-layer graphene oxide (GO) have all been extensively studied and demonstrated to have good antibacterial properties. Besides, some other metallic elements are also used in wound dressings as antimicrobial ingredients.…”

Section: Advanced Functions In Hydrogel Wound Dressingsmentioning

confidence: 99%

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Functional Hydrogels as Wound Dressing to Enhance Wound Healing

2021

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Hydrogels, due to their excellent biochemical and mechnical property, have shown attractive advantages in the field of wound dressings. However, a comprehensive review of the functional hydrogel as a wound dressing is still lacking. This work first summarizes the skin wound healing process and relates evaluation parameters and then reviews the advanced functions of hydrogel dressings such as antimicrobial property, adhesion and hemostasis, anti-inflammatory and anti-oxidation, substance delivery, self-healing, stimulus response, conductivity, and the recently emerged wound monitoring feature, and the strategies adopted to achieve these functions are all classified and discussed. Furthermore, applications of hydrogel wound dressing for the treatment of different types of wounds such as incisional wound and the excisional wound are summarized. Chronic wounds are also mentioned, and the focus of attention on infected wounds, burn wounds, and diabetic wounds is discussed. Finally, the future directions of hydrogel wound dressings for wound healing are further proposed.

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Section: Advanced Functions In Hydrogel Wound Dressingsmentioning

confidence: 99%

Section: Advanced Functions In Hydrogel Wound Dressingsmentioning

confidence: 99%

Functional Hydrogels as Wound Dressing to Enhance Wound Healing

2021

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“…Therefore, the drug can be loaded into the bers to achieve the purpose of reducing the toxic side effects and repeated administration of the excessive drug to the human body. [12][13][14] Among all different types of synthetic polymers, poly(lactic acid) (PLA) has been widely used in recent years because it is an environmentally benign material for potential application prospect as a substitute for medical dressings. 15 This is owed greatly to the polymer's favorable biocompatibility and to its safe degradation products.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of centrifugally spun prepared poly(lactic acid)/gelatin/ciprofloxacin nanofibers for antimicrobial wound dressing

Xia

Liang

et al. 2019

RSC Adv.

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“…In addition, the carrier can also be combined with the target substance by methods such as microsphere embedding, mesoporous particle filling, compound complexation, etc., and then the carrier is dispersed in the hydrogel [ 108 , 109 ]. These methods can prevent the inactivation of active substances in the early stage and can achieve the effect of slow release and sustained release.…”

Section: Resultsmentioning

confidence: 99%

Insights into the Role of Natural Polysaccharide-Based Hydrogel Wound Dressings in Biomedical Applications

Sun

Li²,

Yu³

et al. 2022

Gels

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Acute skin damage caused by burns or cuts occurs frequently in people’s daily lives. Such wounds are difficult to heal normally and have persistent inflammation. Wound dressings not only improve the speed of wound healing, but also protect and cover the wound well. Hydrogels have the characteristics of good flexibility, high water content, and good biocompatibility, and are widely used in biomedicine and other fields. Common hydrogels are mainly natural hydrogels and synthetic hydrogels. Hydrogels cross-linked using different raw materials and different methods have different performance characteristics. Natural hydrogels prepared using polysaccharides are simple to obtain and have good biocompatibility, but are inferior to synthetic hydrogels in terms of mechanical properties and stability, and a single polysaccharide hydrogel cannot meet the component requirements for wound healing. Therefore, functional composite hydrogels with high mechanical properties, high biocompatibility, and high antibacterial properties are the current research hotspots. In this review, several common polysaccharides for hydrogel synthesis and the synthesis methods of polysaccharide hydrogels are introduced, and functional composite hydrogel dressings from recent years are classified. It is hoped that this can provide useful references for relevant research in this field.

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Development of medical drugs: Synthesis and in vitro bio-evaluations of nanomedicinal zinc–penicillins polymeric hydrogel membranes for wound skin dressing by new chemical technology

Cited by 18 publications

References 36 publications

Functional Hydrogels as Wound Dressing to Enhance Wound Healing

Functional Hydrogels as Wound Dressing to Enhance Wound Healing

Fabrication of centrifugally spun prepared poly(lactic acid)/gelatin/ciprofloxacin nanofibers for antimicrobial wound dressing

Insights into the Role of Natural Polysaccharide-Based Hydrogel Wound Dressings in Biomedical Applications

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