Cryptococcosis with Cutaneous Manifestations

Cryptococcosis: Long-lasting Presence of Fungi after Successful Treatment

“…Histopathologically, the skin lesions are divided into two types, i.e. cystic and granulomatous lesions (1,2), each of which occurs exclusively depending on the conditions of individual hosts (3). For unknown reason the titre of cryptococcal antigen in patients' sera may be persistently positive even after treatment with antifungal therapies (4).…”

Cryptococcosis with Cutaneous Manifestations Treated with 5-Fluorocytosine

“…The or ganisms are present in much smaller numbers than in the gelatinous lesions. In patients with only cutaneous lesions the reaction is apt to be granuloma tous as an indication of an effective host response [16], but both types may be seen in the same lesion [15]. This case showed only gelatinous appearance in the skin.…”

“…Two types of histologic reaction to infection with C. neoformans may occur: gelatinous and granulomatous [15]. Gelatinous lesions show numer ous organisms in aggregates, but only very little tissue reaction, and is typi cally present in the central nervous system.…”

“…Cutaneous manifestation usually occurs in about 10-20% of the cases [19], The skin lesions present as papules, nodules, acneiform pustules, or ab scesses with ulceration and crusting with time, but occasionally skin lesions present as vesicles, purpura or a mass [3,15,18], The predilection site is usu ally the face and extremities. Our case presented typical skin findings.…”

Acute Primary Cutaneous Cryptococcosis

“…Here and there the yeast cells formed short chains (3-4 cells); even some germinal tubes were seen in the sections. Their occurrence in pathological tissue has so far been described in only two cases (Moore 1957). For further identification of the yeast, material aspirated from a closed abscess was cultured on Sabouraud agar and blood agar.…”