Cryptococcose neuroméningée chez deux enfants VIH négatif

Adonis-Koffy, L.; Diarrassouba, G.; Mouba, John Florent; Aké-Assi, M.H.; Eboua, François Tanoh; Timité-Konan, M.; Dosso, Mireille

doi:10.1016/j.arcped.2010.03.020

Cited by 7 publications

(4 citation statements)

References 2 publications

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“…Emergency diagnosis of NMC is based on the search for yeasts in the CSF and for circulating antigens. Direct microscopic examination is positive in 72 to 84% of cases, only its sensitivity is not as certain as that of CSF culture which varies from 94 to 100% [9,12] .…”

Section: Discussionmentioning

confidence: 92%

“…It occurs in 80% of cases in people with severe cellular immunosuppression with a median CD4 lymphocytes of 8 cells/mm 3 . However, cases of NMC occurring in patients with CD4 counts above 200 /mm 3 have been reported [11,12] , suggesting that this condition is possible even in stages of moderate immunosuppression. In our patient, we found a normal CD4 count at 610 /mm 3 .…”

Section: Discussionmentioning

confidence: 99%

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Cryptococcus neoformans meningitis in an immunocompetent adult: A case report

et al. 2020

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Neuromeningeal cryptococcosis (NMC) is relatively rare in immunocompetent subjects. We report a Congolese case of NMC diagnosed in an apparently immunocompetent subject. A 35-year-old woman was admitted for acute meningoencephalitis. The cerebrospinal fluid (CSF) examination revealed cytological and biochemical abnormalities and the presence of Cryptococcus neoformans on direct examination with India ink and in culture. The serum dosage of cryptococcal antigens was titrated at 1:32. HIV and syphilis antibodies were negative and the blood CD4 lymphocyte count was 610/mm3. The patient had no other immunosuppressive factors, in particular no hematologic abnormalities, no solid tumor, or malnutrition. She was unsuccessfully treated with fluconazole intraveinously, and died after 10 days of treatment. This observation reminds us that NMC can occur in subjects without apparent immunosuppressive factor with a misleading clinical presentation. It is a rare infection with a severe prognosis even in immunocompetent patients.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Cryptococcus neoformans meningitis in an immunocompetent adult: A case report

et al. 2020

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“…Nous n'avons malheureusement pas pu réaliser un sérotypage de l'isolat sachant que le patient est éleveur de pigeons et que C. neoformans var. grubii (sérotype A) est celui qui est mis en évidence dans les fientes de ce volatile [1,10,17] dans les zones chaudes et humides tropicales et subtropicales. Cette variété est fréquemment rencontrée chez les patients VIH+ tandis que le type B (Cryptococcus gatti) est identifié chez les patients immunocompétents [5].…”

Section: Discussionunclassified

“…Dans des études récen-tes, la grossesse est considérée comme facteur de risque de cryptococcose [13]. Ainsi, la cryptococcose reste exceptionnellement rare chez l'enfant [1].…”

Section: Discussionunclassified