“…Moreover, the scale of mechanochemical reactions has ranged from the mechanical manipulation of single atoms and molecules (predominantly, synthetic and natural polymers) using atomic force microscopy ( Kaupp, 2009 ; Ribas-Arino and Marx, 2012 ; Makarov, 2016 ; Li et al, 2017 ) to the induction of reactions in multi-component inorganic and organic powder mixtures in ball milling reactors or extruders ( Iwasaki et al, 2010 ; Am Ende et al, 2014 ; Oliveira et al, 2017 ; Andersen and Mack, 2018b ; Egleston et al, 2020 ). Alongside synthetic covalent chemical reactions, a wide range of supramolecular assemblies have been also prepared by mechanical treatment, including cocrystals and salts ( Myz et al, 2009 ; Weyna et al, 2009 ; Friščić, 2012 ; Myz et al, 2012 ; Braga et al, 2013 ; Hasa et al, 2015 ), as well as non-covalently bound mechano-composites such as drug delivery devices comprising active pharmaceutical ingredients with excipients ( Shakhtshneider et al, 2007 ; Shakhtshneider et al, 2014a ; Shakhtshneider et al, 2014b ; Lomovsky et al, 2017 ; Ogienko et al, 2018 ; Bychkov et al, 2019 ; Adekenov et al, 2020 ; Skripkina et al, 2020 ). Moreover, many organic mechanochemical syntheses have been successfully scaled-up ( Iwasaki et al, 2010 ; Am Ende et al, 2014 ; Crawford et al, 2017 ; Trofimova et al, 2018 ; Stolar et al, 2019 ; Baláž et al, 2020 ; Crawford et al, 2020 ; He et al, 2020 ; Titi et al, 2020 ; Stolar et al, 2021 ), offering a direct route to translate mechanochemical synthesis toward industrial scale applications.…”