Cryosurgery as an Effective Alternative for Treatment of Oral Lesions in Children

Rezende, Karla Mayra; Moraes, Paulo De Camargo; Oliveira, Luciana Butini; Thomaz, Luiz Alexandre; Junqueira, José Luiz Cintra; Bönecker, Marcelo

doi:10.1590/0103-6440201302254

Cited by 15 publications

(12 citation statements)

References 25 publications

(27 reference statements)

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“…Other direct effects include degradation and inhibition of enzymes, protein damage, and the formation of cellular vacuoles leading to cell rupture . Indirect effects follow the direct effects and include vascular changes leading to ischemic necrosis, owing to the formation of thrombi and microthrombi during transient vasoconstriction . This is complemented by formation of anti‐tumor antibodies followed by phagocytosis mediated by B cells, activation of Natural Killer cells and a cytotoxic T cell mediated immune response .…”

Section: Discussionmentioning

confidence: 99%

“…5,9 Indirect effects follow the direct effects and include vascular changes leading to ischemic necrosis, owing to the formation of thrombi and microthrombi during transient vasoconstriction. 7,9,15 This is complemented by formation of anti-tumor antibodies followed by phagocytosis mediated by B cells, activation of Natural Killer cells and a cytotoxic T cell mediated immune response. 16,17 Moreover, it has recently been demonstrated that apoptosis is instrumental in indirect cellular injury targeting cells at the periphery of the lesion, through mitochondrial damage which causes an activation of the caspase pathway.…”

Section: Discussionmentioning

confidence: 99%

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Nitrous oxide cryotherapy for the management of benign lesions of the oral cavity

Farah

Koelmeyer

Kaney

et al. 2019

J Oral Pathology Medicine

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Background Cryotherapy is the deliberate destruction of tissue by the application of extreme cold, and has been indicated as a treatment modality for the management of commonly occurring benign oral pathologies. The aim of this study was to investigate treatment protocol parameters and effectiveness of a closed cryotherapy system for the management of oral mucoceles and vascular malformations. Methods This retrospective study analyzed data collected from a specialist oral medicine clinic referred for treatment of oral mucoceles or vascular malformations. Data was analyzed to determine lesion characteristics, treatment parameters, and clinical effectiveness of a closed cryotherapy system. Results The closed cryotherapy system achieved 100% success rate in lesion resolution. For both pathologies, increased lesion diameter was related to increased number of cryotherapy appointments, increased number of freeze cycles, and increased cumulative freeze time. 95% of vascular malformations and 83.34% of mucoceles resolved with no signs of post‐operative complication, and patients did not report postoperative pain. Conclusions Cryotherapy is an excellent treatment option for benign lesion management. It is minimally invasive, causes minimal discomfort, and has a high rate of clinical success.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nitrous oxide cryotherapy for the management of benign lesions of the oral cavity

Farah

Koelmeyer

Kaney

et al. 2019

J Oral Pathology Medicine

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“…A case series of loco-regional cutaneous metastasis of melanoma combination therapy of cryosurgery and imiquimod was found to be successful [18]. Cryotherapy as a useful procedure used for other dermatological indications in case series and case reports mentioned in the literature are Xanthelasma palpebrarum, dermatofibrosarcoma protuberans, Refractory cutaneous Rosa Dorfman disease, cutaneous sporotrichosis, and also in oral lesions in children [19][20].…”

Section: Discussionmentioning

confidence: 99%

Cryosurgery in a dermatology setup: a hospital based study

Thapa¹,

Jha²,

Shrestha³

et al. 2018

Our Dermatol Online

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Background: Cryosurgery is the well-aimed and controlled destruction of diseased tissue by application of cold. It has been shown to be effective and efficient in various skin diseases. We studied the indications and outcome of this modality of treatment in our set up. Materials and Method: All patients who were subjected to cryosurgery for different clinical indications were included in the study. Results: There were total of 133 patients. Commonest age group presentation (between 16 to 25 years) constituted about 42%. 52% of patients were students. There were total of 91% who were from Kathmandu remaining 9% were from outside of Kathmandu Valley. Cryosurgery was indicated commonly in warts for 82% patients followed by 12% for keloid & hypertrophic scar, benign conditions in 4% and in premalignant conditions for 2% patients. Number to treatment (or sessions) for indicated disease with resolution of disease was single in 81% patients followed by between 2 to 5 treatment session in 14% and more than 5 treatments was necessary in 5%. Side effects like pain was seen in 64% patients, erythema in 8% and blistering 4%. 24% patients did not have any side effect. Conclusion: Cryotherapy is considered as one of the effective modality of treatment for various skin conditions with various limitations. Further prospective clinical trial with large population group should be carried out.

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“…This treatment has certain advantages over surgery mainly in children. The technique is easily performed, effective, painless, requires no expensive supplies or injectable anesthesia, patients do not have to return for suture removal and it is better tolerated by fearful children [10][11][12][13][14][15][16] .These are the major advantages in Pediatric Dentistry. Surgical excision and sutures can make children and parents anxious.…”

Section: Discussionmentioning

confidence: 99%

Cryosurgery for the treatment of pediatric plunging ranula: a conservative management

Moraes

Teixeira

Thomaz

et al. 2015

RGO, Rev. Gaúch. Odontol.

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RESUMOMuitas modalidades de tratamento têm sido propostas para o tratamento da rânula mergulhante, dentre elas: tratamento cirúrgico incluindo a excisão da glândula sublingual seguida da drenagem transoral da rânula mergulhante, aspiração, e criocirurgia e excisão com laser de CO2. Além dessas modalidades, a marsupialização e micro-marsupialização também podem ser recomendadas para o tratamento de rânulas intraorais. O objetivo deste trabalho será apresentar um caso clínico de rânula mergulhante em um paciente infantil de 8 anos e 6 meses de idade. A lesão foi tratada por meio do uso da criocirurgia, realizada com nitrogênio líquido e sem a aplicação de anestesia local. Serão destacados o protocolo de utilização, vantagens e desvantagens, resultados alcançados e a segurança para o paciente durante o tratamento. Após um ano de acompanhamento, observou-se que a lesão desapareceu completamente e não houve recidiva. Pode-se concluir que o uso da crioterapia com nitrogênio líquido pode ser o tratamento de escolha em relação à cirurgia convencional em pacientes pediátricos.Termos de indexação: Criança. Rânula. Glândula sublingual. Cirurgia. Tratamento.

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Cryosurgery as an Effective Alternative for Treatment of Oral Lesions in Children

Cited by 15 publications

References 25 publications

Nitrous oxide cryotherapy for the management of benign lesions of the oral cavity

Nitrous oxide cryotherapy for the management of benign lesions of the oral cavity

Cryosurgery in a dermatology setup: a hospital based study

Cryosurgery for the treatment of pediatric plunging ranula: a conservative management

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