Nitrous oxide cryotherapy for the management of benign lesions of the oral cavity

Abstract

Background Cryotherapy is the deliberate destruction of tissue by the application of extreme cold, and has been indicated as a treatment modality for the management of commonly occurring benign oral pathologies. The aim of this study was to investigate treatment protocol parameters and effectiveness of a closed cryotherapy system for the management of oral mucoceles and vascular malformations. Methods This retrospective study analyzed data collected from a specialist oral medicine clinic referred for treatment of oral mucoceles or vascular malformations. Data was analyzed to determine lesion characteristics, treatment parameters, and clinical effectiveness of a closed cryotherapy system. Results The closed cryotherapy system achieved 100% success rate in lesion resolution. For both pathologies, increased lesion diameter was related to increased number of cryotherapy appointments, increased number of freeze cycles, and increased cumulative freeze time. 95% of vascular malformations and 83.34% of mucoceles resolved with no signs of post‐operative complication, and patients did not report postoperative pain. Conclusions Cryotherapy is an excellent treatment option for benign lesion management. It is minimally invasive, causes minimal discomfort, and has a high rate of clinical success.

Osteomielitis en cúbito tratado con criocirugía

“…La crioterapia utiliza nitrógeno líquido y dióxido de carbono, en el papel de agentes de congelación para destruir tejido patológico a bajas temperaturas, y elimina las lesiones durante el proceso de curación. 18,19 La cirugía por congelación es un tratamiento reconocido para tumores, lesiones precancerosas y quistes. [20][21][22] Al principio, esta crioterapia se aplicaba sólo a tumores malignos de los labios y lesiones en la cavidad oral, 23 pero desde entonces se ha aplicado en dermatología, oftalmología, otorrinolaringología y cirugía general.…”

“…La temperatura de la zona del daño se recupera con celeridad cuando se detiene la criocirugía. 18,19 Este cambio abrupto de temperatura promueve la formación de cristales de hielo en el compartimento extracelular e intracelular. Un gradiente osmótico provocado por los cristales de hielo extracelulares genera la pérdida de agua intracelular.…”

“…18 Los pacientes presentan pocas complicaciones después de la criocirugía, por ejemplo hiperemia, hinchazón, dolor leve y erosión, pero normalmente se pueden curar sin problemas. 18,19 Por lo tanto, este tipo de cirugía se considera un método sencillo y seguro para la curación.…”

Oral Biofilm Cryotherapy as a Novel Ecological Modulation Approach

“…Such applications, usually using liquid nitrogen, can have some side effects on the gingival tissues, such as hemorrhage, recession, and pain (Özcan et al 2015). Common cryogens include liquid nitrogen (boiling point [bp] of −196°C) and nitrous oxide (bp of −89°C) (Farah et al 2019). Using a cryoprobe or a spray device (no tissue contact), the cryogen can be delivered to the afflicted tissues.…”

The use of high and low power lasers in the treatment of mucocele in lip: a case report

“…Mucocele treatment is currently performed through a variety of options: iodine tincture (3); sclerotherapy by injection of pingyangmycin or anhydrous alcohol (7); cryotherapy (8) and micromarsupialization therapy (9). However, scalpel excision is still the most used treatment, even causing greater intraoperative bleeding, post-surgical edema, scarring and considerable risk of causing damage to other ducts of the minor salivary glands close to the lesion (3).…”