Cryoprinting of nanoparticle-enhanced injectable hydrogel with shape-memory properties

Wang, Yu; Zhou, Xizhao; Zhu, Shunyao; Gao, Yanxiang; Zhou, Nazi; Liao, Xueyuan; Peng, Yiming; Tang, Yaping; Zhang, Lin; Yang, Xi; Li, Yang; Xu, Xiang Xi; Tao, Jie; Li, Rui

doi:10.1016/j.matdes.2022.111120

Cited by 11 publications

(17 citation statements)

References 58 publications

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“…morphology. [50,51] In 2022, Wang et al [52] combined light-based 3D printing with cryogelation to produce a cryoprinting facility that could fabricate cryogels with customized features and shapememory nature. The Silk fibroin/laponite scaffolds thus developed manifested rapid recovery post-injection of the scaffolds.…”

Section: Silk Cryogelsmentioning

confidence: 99%

Emerging Strategies in Stimuli‐Responsive Silk Architectures

Prakash

Sarkar

Kandasubramanian

2023

Macromolecular Bioscience

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The utilization of implantable devices beseeches highly invasive surgeries considering the adversaries in the insertion of large, impliable devices through the body channels, which necessitate the development of implantable devices using biocompatible shape memory polymers. Silk displays prodigious heterogeneity in its genetic structure and physical properties in accordance with the spinning and storage process, where proteins undergo folding and unfolding. The stimuli‐responsive nature of silk can be explained with the help of the structural morphology and composition of the material, where the hydrogen bonds in β‐sheet domains and amorphous region act as switch points and net points, respectively. This review provides a primary attempt to enswathe all the literature available to date on the stimuli‐responsive nature of silk and silk‐based materials as a natural and biodegradable alternative for commercially used synthetic shape memory materials taking their elastomeric nature and reduction in glass transition temperature into account. Further constitutive model using the continuum approach has been utilized to explain the anisotropic elasticity damping effect and plastic deformation based on the α‐helix chains, β‐sheets, and β‐spiral structures. The practicability to develop biomedical devices such as patient‐specific‐injectable scaffolds, drug carriers, and artificial muscles has been encompassed in this article.

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Section: Silk Cryogelsmentioning

confidence: 99%

Emerging Strategies in Stimuli‐Responsive Silk Architectures

Prakash

Sarkar

Kandasubramanian

2023

Macromolecular Bioscience

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“…One of the critical challenges in applying cryogels for tissue engineering is that the shapes of tissue defects are mostly irregular, and by the conventional molding method, it is very difficult to fabricate cryogels that can fill exactly in the defect site [ 82 , 83 ]. To solve this issue, Wang et al [ 74 ] recently presented a 3-D cryoprinting technique to fabricate injectable cryogels composed of laponite nanoparticles (LAP) and SF in predesigned sizes and shapes ( Figure 2 ). In vitro studies and animal model experiments proved that the printed cryogels can promote attachment, propagation, migration, and osteogenic differentiation of the BMSCs.…”

Section: Biomedical Application Of Silk-based Cryogelsmentioning

confidence: 99%

“…We finally discussed specific applications where cryogels have unique advantages. For example, silk cryogels have been used in IVD, cartilage, liver, muscle, and bone tissue engineering applications [ 14 , 22 , 57 , 74 ]. Cryogels made out of silk-based biomaterials consistently outperformed other scaffolds by offering unique properties where their macroporous structure supports cell growth and migration including nutrient and waste transport, and can improve the speed of scaffolds vascularization [ 70 ].…”

Section: Conclusion and Future Directionmentioning

confidence: 99%

“…On the other hand, when using silk sericin in drug delivery applications, mechanisms that are based on degradation using non-enzymatic approaches of silk could significantly improve their utility [ 99 ]. Finally, we were able to review only a handful of references that use silk-based cryogels in 3-D printing applications [ 74 ]. Therefore, we believe there is a significant gap in the application of silk-based cryogels when compared to other biomaterial precursors.…”

Section: Conclusion and Future Directionmentioning

confidence: 99%

“…( e ) H&E staining of the printed LAP@SF cryogel scaffold after 3, 7, and 14 days of implantation; left, scale bar = 200 µm; right, scale bar = 100 µm. Reused with some rearrangement with permission of [ 74 ] (Under a Creative Commons license: CC BY-NC-ND 4.0).…”

Section: Figurementioning

confidence: 99%

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Designing Silk-Based Cryogels for Biomedical Applications

Abdullah

Memić

2022

Biomimetics

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There is a need to develop the next generation of medical products that require biomaterials with improved properties. The versatility of various gels has pushed them to the forefront of biomaterials research. Cryogels, a type of gel scaffold made by controlled crosslinking under subzero or freezing temperatures, have great potential to address many current challenges. Unlike their hydrogel counterparts, which are also able to hold large amounts of biologically relevant fluids such as water, cryogels are often characterized by highly dense and crosslinked polymer walls, macroporous structures, and often improved properties. Recently, one biomaterial that has garnered a lot of interest for cryogel fabrication is silk and its derivatives. In this review, we provide a brief overview of silk-based biomaterials and how cryogelation can be used for novel scaffold design. We discuss how various parameters and fabrication strategies can be used to tune the properties of silk-based biomaterials. Finally, we discuss specific biomedical applications of silk-based biomaterials. Ultimately, we aim to demonstrate how the latest advances in silk-based cryogel scaffolds can be used to address challenges in numerous bioengineering disciplines.

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Fe₃O₄‐nanoparticle‐functionalized 3D‐printed injectable microgel

Wei,

Zheng,

Zhu

et al. 2023

J of Applied Polymer Sci

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Magnetic Fe3O4 nanoparticles have attached attention in bone tissue engineering because of their superior magnetism and great biocompatibility. However, some disadvantages such as the potential risk of agglomeration impair their applications. Here, we proposed a hybrid magnetic nanocomposite microgel by the integration of Fe3O4 nanoparticles and digital lighting processing (DLP) three‐dimensional (3D) printing technology. The 3D‐printed microgels could be precisely customized by printing the mixture of gelatin methacryloyl (GelMA) solution and polydopamine‐coated Fe3O4 nanoparticles, in which polydopamine decoration improved the hydrophilicity and distribution of the incorporated Fe3O4. The degradable microgels could be injected through a 22‐G needle while retaining their original shape after injection. Interestingly, the addition of Fe3O4 nanoparticles into GelMA solution displayed improved printing accuracy. Moreover, these magnetic microgels were biocompatible in vitro and in vivo. After induction within osteogenic medium, addition of nanoparticles upregulated the osteogenic gene expression of rat bone mesenchymal stem cells (BMSCs). In a word, this work provides a magnetic microplatform, which shows great potential in bone tissue engineering.

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Cryoprinting of nanoparticle-enhanced injectable hydrogel with shape-memory properties

Cited by 11 publications

References 58 publications

Emerging Strategies in Stimuli‐Responsive Silk Architectures

Emerging Strategies in Stimuli‐Responsive Silk Architectures

Designing Silk-Based Cryogels for Biomedical Applications

Fe₃O₄‐nanoparticle‐functionalized 3D‐printed injectable microgel

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Cryoprinting of nanoparticle-enhanced injectable hydrogel with shape-memory properties

Cited by 11 publications

References 58 publications

Emerging Strategies in Stimuli‐Responsive Silk Architectures

Emerging Strategies in Stimuli‐Responsive Silk Architectures

Designing Silk-Based Cryogels for Biomedical Applications

Fe3O4‐nanoparticle‐functionalized 3D‐printed injectable microgel

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Product

Resources

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Fe₃O₄‐nanoparticle‐functionalized 3D‐printed injectable microgel