Cryoglobulins in Coronary-Artery Disease

Cryoglobulinemia and Cerebrovascular Accident

“…The occurrence of cerebral ischemic stroke in our rela tively young patients without any evidence of other disease, apart from essential cryoglobulinemia, raises the possibility of a close relationship between these two conditions. Arteriolar and arterial obstructions in the lungs, kidneys, and extremi ties have been described in cryoglobulinemia, and there is also a pre sumed connection between coronary artery disease and cryoglobulinemia [5,8]. It is, therefore, reasonable to assume that the same process may occur in the cerebral vessels.…”

Coronary Artery Disease

“…These and other observations have still to be correlated. Cold precipitable substances (cryoglobulins) in atherosclerotic disease (James and Drake, 1953) have been noted. Mucoproteins and hexosamines in the plasma (Schwarz and Gilmore, 1958) may be associated with depolymerization of connective tissue mucopolysaccharides, and draw attention again to tissue plasma interrelations.…”