Cryogenic Numbing to Reduce Injection Discomfort during Indocyanine Green Lymphography

Suami, Hiroo; Heydon-White, Asha; Mackie, Helen; Koelmeyer, Louise; Boyages, John

doi:10.1055/s-0038-1667362

Cited by 7 publications

(4 citation statements)

References 4 publications

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“…A cryogenic numbing device (CoolSense; CoolSense Medical Ltd., Tel Aviv, Israel) was applied for three seconds, immediately before each injection to reduce needle discomfort. 18 Lymphatic scanning using the near-infrared camera system (PDE Neo II; Hamamatsu Photonics K.K., Hamamatsu, Japan) commenced immediately after the injections and imaging data was recorded using a digital video recorder (MDR-600HD: Ikegami Tsushinki Co., Ltd., Tokyo, Japan). Lymphatic imaging of the lower limb was continuously conducted for approximately one hour.…”

Section: Icg Lymphography Imaging Protocolmentioning

confidence: 99%

A new indocyanine green fluorescence lymphography protocol for diagnostic assessment of lower limb lymphoedema

Suami¹,

Thompson²,

Mackie³

et al. 2022

Journal of Plastic, Reconstructive & Aesthetic Surgery

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Section: Icg Lymphography Imaging Protocolmentioning

confidence: 99%

A new indocyanine green fluorescence lymphography protocol for diagnostic assessment of lower limb lymphoedema

Suami¹,

Thompson²,

Mackie³

et al. 2022

Journal of Plastic, Reconstructive & Aesthetic Surgery

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“…To the authors' knowledge, this is the first reported use of the CoolSense device in animals. Other reports have shown it to be effective before intravenous catheterisation in children, 4 as well as for procedures involving intradermal injections 5 …”

Section: Discussionmentioning

confidence: 99%

“…Whilst planning a pharmacokinetic study requiring multiple, repeated percutaneous fine needle aspirations in sheep, we chose to test a commercially available analgesic device (CoolSense; Coolsense Ltd). Although the device has been shown to be effective in reducing needle‐stick pain in humans, 4,5 there was no reported evaluation of the CoolSense device in veterinary species.…”

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confidence: 99%

Observations on the use of a pain numbing device for repetitive percutaneous sampling in sheep

et al. 2021

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Aims To evaluate the success of a commercially available analgesic device (CoolSense; Coolsense Ltd, Tel Aviv, Israel) in ameliorating pain while sampling from subcutaneous tissue cages in sheep. Methods The CoolSense device was used as part of a major parent study involving repetitive percutaneous sampling of subcutaneous tissue cages in seven sheep. Sampling was performed by passing a hypodermic needle through the skin and withdrawing fluid from the tissue cage. Each sheep had 10 tissue cages that were individually sampled 14 times over 74 h. The device was placed on the skin of the sampling site immediately before sampling cooling and numbing the skin. The reaction of the sheep was observed by the operators, flinching or jumping as the needle was passed through the skin was deemed to be a failure. We recorded the success or failure of the device for each needle stick. This was opportunistic data collection as part of a pharmacokinetic trial, therefore no controls were included. Results A total of 1655 observations were recorded and then analysed using a generalised linear mixed model. Overall, 1380 of 1655 (83.4%) observations were recorded as successfully providing analgesia. Marked inter‐occasion variability was noted with success ranging from 61.42% to 92.86% across sheep:period (approximately 140 observations each). As no controls were available, the effect of treatment could not be evaluated. Conclusions and clinical relevance The CoolSense device is a viable option for veterinary research and clinical applications.

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“…4 A more recent proposal was to utilize a cryogenic numbing device Cool Sense (CoolSense, Tel Aviv, Israel) to temporarily numb the site before injection. 5 A third technique was discovered by our team while visiting Dr. Takumi Yamamato in 2018. We witnessed his team inject patients utilizing a formulation of indocyanine green with 5% dextrose solution with seemingly little patient discomfort.…”

mentioning

confidence: 99%

Improving the Patient Experience with Indocyanine Green Lymphography

Tillotson

Thomson

Pardo

et al. 2022

Plastic &Amp; Reconstructive Surgery

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Cryogenic Numbing to Reduce Injection Discomfort during Indocyanine Green Lymphography

Cited by 7 publications

References 4 publications

A new indocyanine green fluorescence lymphography protocol for diagnostic assessment of lower limb lymphoedema

A new indocyanine green fluorescence lymphography protocol for diagnostic assessment of lower limb lymphoedema

Observations on the use of a pain numbing device for repetitive percutaneous sampling in sheep

Improving the Patient Experience with Indocyanine Green Lymphography

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