Cryoablation for locally advanced pancreatic cancer

Ionkin, D A; Karelskaya, N.; Stepanova, Y.; Zemskov, V. M.; Козлова, М. Н.; Zhavoronkova, O. A.; Чжао, А. В.

doi:10.16931/1995-5464.2018237-49

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…The survival rates of patients after 6, 12, 24 and 36 months were 92%, 84%, 48% and 14%, respectively, and the median survival was 18.2 months. According to researchers, some survival increase was noted upon combination with chemotherapy [37].…”

Section: Complex Chemoradiation Therapymentioning

confidence: 99%

Pancreatic Cancer: Statistics And Treatment In The Russian Federation

et al. 2020

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Pancreatic cancer (PC) is one of the most fatal types of oncological disease in the world and is an extremely aggressive cancer with a poor prognosis. The objective of this review was to analyze the domestic data of the incidence of PC in the Russian Federation and to analyze the protocols that are used for the management of this group of patients in Russian clinical centers. For the analysis of the literature sources, the data in the elibrary.ru database published in the period from 2015 to 2019 were used. The methodology that was used in each study was examined in order to ensure its reliability, and these data were selected as potential sources of evidence for the preparation of national recommendations. The study results influence the level of evidence assigned to the publication. Updates to the national recommendations are conducted at least once every three years, and these updates depend on new information about the diagnosis and management of patients with PC.

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Section: Complex Chemoradiation Therapymentioning

confidence: 99%

Pancreatic Cancer: Statistics And Treatment In The Russian Federation

et al. 2020

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Repeated irreversible electroporation in a locally advanced pancreatic cancer

Polyakov¹,

Подлужный²,

Кудашкин³

et al. 2022

Issled. prakt. med. (Print)

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It is reasonable to consider the technical possibility and oncological feasibility of the local tumor destruction in patients with locally advanced pancreatic cancer (PCa). Irreversible electroporation (IRE) is a non-thermal method of local tumor ablation, which uses non-thermal energy of high-voltage ultrashort electric fields localized between electrodes to create nanopores in the cellular wall with the following cellular death. The zone of impact can be accurately predicted using the location of the electrodes. A fairly clear and controlled ablation boundary without a clinically significant zone of perifocal tissue damage reduces the risk of accidental injury to the wall of a hollow organ. The method is based on a change in the permeability of the cell membrane and the development of apoptosis, which allows to act directly on the ducts and the great vessels infiltrated by the tumor without a high risk of damage. The presented case shows that IRE is advisable to use as a part of the combined treatment of patients with locally advanced PCa. There were no complications observed after the IRE. Radiological evaluations and pathologic reports showed an adequate long-term local control. Also, good results were obtained in the overall life expectancy, given that we are talking about unresectable ductal adenocarcinoma of the pancreas. The patient passed away in 39 months from the beginning of the treatment and in 26 months from the initial IRE. In case of local relapse, repeated electroporation with a good long-term result is also possible. The time to progression exceeded eleven months after electroporation performed for a local relapse. According to magnetic resonance imaging, both locoregional relapse and distant liver metastases were detected. The patient lived 16 months after a repeated IRE session and died of pulmonary embolism on the background of chemotherapy. Favorable prognostic factors are the presence of an objective response to previous conservative treatment, compliance with the parameters of electroporation, complete inclusion of tumor infiltration in the affected area.

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Cryoablation for locally advanced pancreatic cancer

Cited by 2 publications

References 11 publications

Pancreatic Cancer: Statistics And Treatment In The Russian Federation

Pancreatic Cancer: Statistics And Treatment In The Russian Federation

Repeated irreversible electroporation in a locally advanced pancreatic cancer

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