Cry Analysis of Infants With Karyotype Abnormality

Abstract

Sound spectrography was used to analyze 135 pain cries from 14 infants with a karyotype abnormality. At the time of the cry recording the children were from one day to seven months old, except for one child who was 2 years 10 months at the second recording. The cries were compared with 30 pain cries from 15 healthy infants of corresponding age. The children with an abnormality of chromosome 4 or 5 had cries with a significantly higher fundamental frequency than the control infants. Additionally, the cry in the "Cri-du-Chat" syndrome had a flat, monotonous melody type. The cries of infants with 13- or 18-trisomy were hoarse, low-pitched, with the shift parts absent. The cries in karyotype abnormalities were also different from pain cries of infants with other disorders involving the central nervous system. This study suggests that cry analysis can provide a valuable indication of the presence of a chromosome anomaly.

Assessment of infant cry: Acoustic cry analysis and parental perception

“…In addition to frank neurological damage, many of the early researchers also examined cry characteristics in in- 1 f0, 1 f0 instability (biphonation), 1 subharmonic break, 1 or 2 duration Brain damage Fisichelli and Karelitz, [1966]; Karelitz and Fisichelli, [1962]; Sirviö and ; Wasz-Höckert et al, [1968] 1 f0, 1 f0 instability (biphonation), 2 duration, 1 threshold, 1 latency, 1 short utterances Cri-du-chat Vuorenkoski et al, [1966]; Wasz-Höckert et al, [1968] 1 f0 Down syndrome Fisichelli and Karelitz, [1966]; Wasz-Höckert et al, [1968] 2 f0, 1 f0 variability, 2 intensity (amplitude) Hydrocephalus Michelsson et al, [1984] 1 f0, 1 f0 instability, 1 latency Hypothyroidism Michelsson and Sirviö, [1976] 2 f0 Krabbe's Disease Thodén and Michelsson, [1979] 1 f0, Meningitis (Bacterial) Michelsson et al, [1977b] 1 f0, 1 f0 instability (biphonation), 2 duration Trisomy 13, 18, 21 Michelsson et al, [1980]; Lind et al, [1970]; Ostwald et al, [1970] 2 f0 fants at risk for poor outcomes based on potential neurological insult including prematurity and hyperbilirubinemia. The recent generation of cry studies not only studied cries of infants who were premature or had hyperbilirubinemia, but also examined the effects of potential prenatal insult during pregnancy from lead exposure and exposure to drugs of abuse.…”

A Suggestive Diagnostic Technique For Early Identification Of Acyanotic Heart Disorders From Infant’s Cry

“…During crying, volume, pitch (fundamental frequency) and tone color changes [2] .This could lead to the diagnosis of some diseases and abnormalities. Investigations of cry have been done on different medical problems like oropharyngeal anomalies, asphyxia, neonatorum, symptomless Low birth weight, herpes encephalitis, congenital hypothyroidism, hyperbilurubinemia, bacterial meningitis, Hydrocephalus, bradycardia, various forms of brain damage, malnutrition, genetic defects and sudden infant death syndrome (SIDS) [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. Cry signals of hunger, pleasure and at the time of birth were analyzed by Wasz-Hockert [18].…”

Cry analysis in infants with Rh haemolytic disease

“…Features characteristic of the cries of infants with deletion of chromosome no. 5 or the cri du chat syndrome are high fundamental frequency, flat or r~ing melody form and long duration of crying (129,161,169,200,201). The cries of infants with 13 and 18 trisomy are variable in duration, fundamental frequency is low and the occurrence of glottal roll is increased.…”

“…The cries of infants with 13 and 18 trisomy are variable in duration, fundamental frequency is low and the occurrence of glottal roll is increased. Only a few patients have been studied, however (201,202).…”

“…Furcation and biphonation are rarely found in healthy infants (I.S7, 163) and furcation also seems to be rare in connection with disease other than hyperbilirubinaemia, whereas biphona-tion seems to be quite common in many diseases involving the central nervous system such as asphyxia (160,166) hypoglycaemia (88, 213, 214}, meningitis (208) and chromosomal aberrations (201). Furcation, was first described in a hyperbilirubinaemic infant by Partanen et al, in 1967 (133), who called it a very peculiar subharmonic break.…”