Signals from 11 shots and 8 earthquakes, and numerous teleseismic events were recorded along the 400-km seismic line INDEPTH III in central Tibet and interpreted together with previous seismic and tectonic data. The abnormal behavior of various mantle phases reveals a complex Moho-transition zone, especially in the northern part of the line, in the Changtang Block, where the lower crust and the mantle show unusually low velocities, a shingled appearance of P n and no low-velocity layer in the upper crust. The strong east -west anisotropy in the Changtang Block is related to an easterly escape movement of the whole lithosphere, facilitated by the warm and weak layers in the lower crust and the upper mantle, bounded apparently by two prominent west -east running fault zones. D