Crude extract of black seed (Nigella sativa) can modulate T CD4+CD25+FoxP3+ lymphocytes in asthmatic mouse model

Barlıanto, Wisnu; Kusuma, H.M.S. Chandra; Widodo, M. Aris; Suharto, Slamet

doi:10.1016/s1526-0542(12)70068-4

Cited by 5 publications

(8 citation statements)

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“…Previous studies about probiotic and Nigella sativa in ashtma showed that they can induced Treg cells and production of IL-10. [18,27,32].…”

Section: Discussionmentioning

confidence: 99%

“…Many in vivo and in vitro studies showed beneficial effect of administration of NS in ashtma. Animal study by Barlianto et al (2012) showed NS able to decrease the number of CD4+ T lymphocytes, increase the number of Treg cells, prevent airway remodelling and modulate immune response. Other study show Nigella sativa had relaxation and anti histamin effect in the ashmatic mice trachea.…”

Section: The Effect Of House Dust Mite Immunotherapy Probiotic and Nmentioning

confidence: 99%

“…Study by Ahmad et al in 5-15 years old pediatric patient with wheeze show improvement of a peak expiratory flow rate (PEFR) after treatment with NS. [17][18][19][20] Immunotherapy can improve 60-70% clinical score in ashtmatic patients. However, immunotherapy in ashtmatic patients seldom results in complete alleviation of symptoms, and its long duration of treatment cause many patients drop out before completing it.…”

Section: The Effect Of House Dust Mite Immunotherapy Probiotic and Nmentioning

confidence: 99%

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The Effect of House Dust Mite Immunotherapy, Probiotic and Nigella sativa in The Number of CD4+ IL-4 + Cell, Total IgE level and Asthma Control Test (ACT) Score

Sugiono¹

2013

IOSR-JDMS

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Ashtma is a chronic inflammatory disorder of the airways dominated by Th2. Immunotherapy was beneficial for ashtma patients. Its long duration was oftenly caused patients to drop out treatment. Probiotic and Nigella sativa as immunomodulator for asthma expectantly could increase the efficacy of immunotherapy. The aims of this study was to evaluate the therapeutic efficacy of immunotherapy combined with probiotics and Nigella sativa in the number of CD4 + IL-4 + cells, Total IgE level and Asthma Scoring Test. A total of 31 children with mild asthma were evaluated and then randomized to receive immunotherapy or immunotherapy plus Nigella sativa or immunotherapy plus probiotic or immunotherapy plus Nigella sativa plus probiotic openly for 14 weeks. Statistical analysis found no significant difference in the mean number of CD4 + IL-4 + cells pre and posttest in all three treatment group. The Total IgE level was decreased significantly in the immunotherapy+ probiotic + Nigella sativa group (p = 0,022). The ACT score were increased in the immunotherapy + Nigella sativa group (p = 0.001), in the immunotherapy + probiotic group (p = 0.004), and immunotherapy + Nigella sativa + probiotic group (p = 0.000). Correlation test found a significant association between the number of CD4 + IL-4 + cells, Total IgE level and ACT score in all groups. The combination immunotherapy, Nigella sativa and probiotics could decrease the Total IgE level thus improve the clinical symptom.

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“…Previous studies about probiotic and Nigella sativa in ashtma showed that they can induced Treg cells and production of IL-10. [18,27,32].…”

Section: Discussionmentioning

confidence: 99%

Section: The Effect Of House Dust Mite Immunotherapy Probiotic and Nmentioning

confidence: 99%

Section: The Effect Of House Dust Mite Immunotherapy Probiotic and Nmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of House Dust Mite Immunotherapy, Probiotic and Nigella sativa in The Number of CD4+ IL-4 + Cell, Total IgE level and Asthma Control Test (ACT) Score

Sugiono¹

2013

IOSR-JDMS

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“…Subijanto & Diding (2008) also stated that Nigella sativa seed oil can reduce the degree of airway inflammation comparable to 3 rd generation antihistamines in murine models of asthma [39]. Nigella sativa can increase the number of lymphocytes TCD4 + CD25 + FoxP3 + and CD8 + T lymphocytes as well as decrease the amount of CD4 + T lymphocytes [40,41]. No studies explained about the effects of Nigella sativa on the number of Th17 cells.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown the benefits of Nigella sativa seeds in improving the symptoms of asthma and allergic rhinitis [21,22]. reported that administration of Nigella sativa can increase the number of lymphocytes T CD4 + CD25 + FoxP3 +, inhibits airway remodeling, and modulate the immune response in murine models of asthma [23]. While Ahmad et al (2010) found an improvement in peak expiratory flow rate (PEFR) after administration of Nigella sativa in children aged 5-15 years who suffer from lower respiratory tract infections with wheezing [24].…”

Section: The Effect Of House Dust Mite Immunotherapy Probiotic and Nmentioning

confidence: 99%

The Effect of House Dust Mite Immunotherapy, Probiotic and Nigella sativa in The Number of Th17 Cell and Asthma Control Test Score

Kardani¹,

Fitri²,

Barlıanto³

et al. 2013

IOSR-JDMS

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The Role of Th17 cells in the pathogenesis of asthma and immunotherapy is being a new concept and paradigm. Immunotherapy on asthma requires long periods of time, so administration of an adjuvant had been considered to improve its efficacy. The aims of this study was to evaluate the therapeutic efficacy of immunotherapy combined with probiotics and Nigella sativa in the number of Th17 cells and the improvement of clinical symptoms of asthma. A total of 31 children with mild asthma were evaluated and then randomized to receive immunotherapy or immunotherapy plus Nigella sativa or immunotherapy plus probiotic or immunotherapy plus Nigella sativa plus probiotic openly for 14 weeks. Statistical analysis found no significant difference in the mean number of Th17 cells pre and post test in all four treatment groups, however we found a significant differences asthma control test (ACT) score before and after the immunotherapy + Nigella sativa treatment (p = 0.001), before and after immunotherapy + probiotic treatment (p = 0.004), as well as before and after immunotherapy plus Nigella sativa plus probiotic treatment (p = 0.000). Correlation test found a significant association between the number of Th17 cells and ACT score in all groups. The combination immunotherapy with Nigella sativa and probiotics did not reduce the number of peripheral blood Th17 cells mild asthmatic children, but can improve the clinical symptom.

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Nigella sativa L. as immunomodulator and preventive effect on renal tissue damage of lupus mice induced by pristane

Hikmah

Endaryanto

Ugrasena

et al. 2022

Heliyon

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Crude extract of black seed (Nigella sativa) can modulate T CD4+CD25+FoxP3+ lymphocytes in asthmatic mouse model

Cited by 5 publications

References 0 publications

The Effect of House Dust Mite Immunotherapy, Probiotic and Nigella sativa in The Number of CD4+ IL-4 + Cell, Total IgE level and Asthma Control Test (ACT) Score

The Effect of House Dust Mite Immunotherapy, Probiotic and Nigella sativa in The Number of CD4+ IL-4 + Cell, Total IgE level and Asthma Control Test (ACT) Score

The Effect of House Dust Mite Immunotherapy, Probiotic and Nigella sativa in The Number of Th17 Cell and Asthma Control Test Score

Nigella sativa L. as immunomodulator and preventive effect on renal tissue damage of lupus mice induced by pristane

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