Nigella sativa L. as immunomodulator and preventive effect on renal tissue damage of lupus mice induced by pristane

Hikmah, Zahrah; Endaryanto, Anang; Ugrasena, I Dewa Gede; Rahaju, Anny Setijo; Arifin, Syaiful

doi:10.1016/j.heliyon.2022.e09242

Cited by 9 publications

(3 citation statements)

References 43 publications

(51 reference statements)

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“…For mothers who give birth more than once, breast milk production is much higher than for mothers who give birth for the first time. The number of deliveries that the mother has undergone affects their baby experience (Hikmah et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

The Effect of Black Cumin (Nigella Sativa) on Breastfeeding Mothers

Zakaria

Astuti

2022

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Breast milk is the best nutrient to reduce the pain in nursing mothers and death in infants. However, for nursing mothers, too little milk volume is the cause of problems occurring during the breastfeeding process. Thus, mothers who breastfeed should consume foods that can increase the breast milk volume. One food frequently consumed by mothers to increase breast milk is honey. In fact, natural honey is challenging to discover, and the price is also high which makes it as an obstacle. A more economical alternative is required, one of which is black cumin. It is easy to obtain and the price is also affordable. Black cumin also contains galactagogue to increase prolactin that influences breast milk production. The objective of this study is to identify the effect of black cumin on the volume of breast milk. The study was a randomized controlled trial involving 60 breastfeeding mothers divided into intervention groups and control groups. The intervention group was provided 15 grams of black cumin brewed with 1000C boiling water as much as 200 ml, and the control group was assigned 15 grams of pure honey brewed boiling 1000C as much as 200 ml. Intervention and control were administered on the second day to the day of completion after giving birth. They were measuring instruments which accustomed to measure breast milk pumps. Bivariate analysis employing the Wilcoxon and Mann Whitney tests presented a significant difference between the volume of breast milk (p = 0.001) of the control and intervention groups. This study recommends the application of black cumin as a strategy to increase the volume of breast milk in nursing mothers.

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Section: Resultsmentioning

confidence: 99%

The Effect of Black Cumin (Nigella Sativa) on Breastfeeding Mothers

Zakaria

Astuti

2022

j. info kesehat.

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“…Methyl salicylate 2-O-β-D-lactoside-salicylic acid analogue extracted from the herbal medicine Gaultheria yunnanensis and coptisine, alkaloid in the dried rhizome of Coptis chinensis, have been previously reported to ameliorate lupus-like disease in pristine-treated mice [27,28]. Nigella sativa L. used in traditional Indonesian medicine, Baicalein-flavonoid derived from the roots of the herbal medicine Scutellaria baicalensis Georgi and 3β-acetyloxyoleanolic acid, isolated from the root of Symplocos laurina, also showed an anti-inflammatory and protective effect on the development of lupus nephritis in this murine model [29,30]. Other substances, such as tofacitinib and melatonin, also alleviated the progression of pristane-induced lupus [31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Methyl‐supplemented nutrition delays the development of autoimmune disease in pristane‐induced murine lupus

Bradyanova,

Manoylov,

Boneva

et al. 2024

Immunology

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The aetiology and progression of systemic lupus erythematosus (SLE) resulted from a complex sequence of events generated both from genetic and epigenetic processes. In the current research, the effect of methyl‐supplemented nutrition on the development of SLE was studied in the pristane‐induced mouse model of the disease. The results clearly demonstrated decreased anti‐dsDNA antibody and proteinuria levels, modulation of cytokines and protected renal structures in the group of treated mice. An additional increase in the DNA methylation of mouse B lymphocytes was also observed. The beneficial effect of the diet is due to the methyl‐containing micronutrients with possible anti‐inflammatory and immunomodulating effects on cell proliferation and gene expression. Since these components are responsible for maintaining the physiological methylation level of DNA, the results point to the central role of methylation processes in environmentally triggered lupus. As nutrition represents one of the major epigenetic factors, these micronutrients may be considered novel agents with significant therapeutic outcomes.

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“…It also decreases serum malondialdehyde (MDA) levels and liver enzymes (Mohany et al, 2012).TQ downregulates TLR2, TLR4, TNF-α, IL-1, and NFκB expression levels (Arjumand et al, 2019). It also decreases the (IL-17, IL-6, IL-23) expression in renal tissue damage pristane-induced Lupus (PIL)-mice model (Hikmah et al, 2022).…”

Section: Thymoquinonementioning

confidence: 99%

An outlook on the target‐based molecular mechanism of phytoconstituents as immunomodulators

Noor,

Badruddeen,

Akhtar

et al. 2023

Phytotherapy Research

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The immune system is one of the essential defense mechanisms. Immune system inadequacy increases the risk of infections and cancer diseases, whereas over‐activation of the immune system causes allergies or autoimmune disorders. Immunomodulators have been used in the treatment of immune‐related diseases. There is growing interest in using herbal medicines as multicomponent agents to modulate the complex immune system in immune‐related diseases. Many therapeutic phytochemicals showed immunomodulatory effects by various mechanisms. This mechanism includes stimulation of lymphoid cell, phagocytosis, macrophage, and cellular immune function enhancement. In addition increased antigen‐specific immunoglobulin production, total white cell count, and inhibition of TNF‐α, IFN‐γ, NF‐kB, IL‐2, IL‐6, IL‐1β, and other cytokines that influenced the immune system. This review aims to overview, widely investigated plant‐derived phytoconstituents by targeting cells to modulate cellular and humoral immunity in in vivo and in vitro. However, further high‐quality research is needed to confirm the clinical efficacy of plant‐based immunomodulators.

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Nigella sativa L. as immunomodulator and preventive effect on renal tissue damage of lupus mice induced by pristane

Cited by 9 publications

References 43 publications

The Effect of Black Cumin (Nigella Sativa) on Breastfeeding Mothers

The Effect of Black Cumin (Nigella Sativa) on Breastfeeding Mothers

Methyl‐supplemented nutrition delays the development of autoimmune disease in pristane‐induced murine lupus

An outlook on the target‐based molecular mechanism of phytoconstituents as immunomodulators

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