Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T‐cell leukemia‐derived cells

Nasu, Keiichirō; Yamaguchi, Kazunori; Takanashi, Tomoka; Tamai, Keiichi; Sato, Iwao; Ine, Shoji; Sasaki, Osamu; Satoh, Kennichi; Tanaka, Nobuyuki; Tanaka, Yuetsu; Fukushima, Takuya; Harigae, Hideo; Sugamura, Kazuo

doi:10.1111/cas.13163

Cited by 8 publications

(7 citation statements)

References 34 publications

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“…The signal transduction activity of CA IX is activated when the tyrosine residue at position 449 is phosphorylated [ 215 , 216 ]. CA IX has also been shown to be a key modulator of tumor growth, survival and migration, tumorigenesis, pH control, cell adhesion, and proliferation, and is the basis of studies used to establish mechanisms proposed in both Hypothesis 1 and 2 presented in earlier sections ( Figure 1 ) [ 33 , 52 , 202 , 217 , 218 ]. CA IX expression is regulated by tumor hypoxia and has not only been established as a prognostic indicator for a variety of cancers but also as an anticancer target.…”

Section: Membrane Associated Ca Isoforms: Expression Distributionmentioning

confidence: 99%

Carbonic Anhydrases: Role in pH Control and Cancer

et al. 2018

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The pH of the tumor microenvironment drives the metastatic phenotype and chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH-dependent phenomenon will lead to improved drug delivery and allow the identification of new therapeutic targets. This includes an understanding of the role pH plays in primary tumor cells, and the regulatory factors that permit cancer cells to thrive. Over the last decade, carbonic anhydrases (CAs) have been shown to be important mediators of tumor cell pH by modulating the bicarbonate and proton concentrations for cell survival and proliferation. This has prompted an effort to inhibit specific CA isoforms, as an anti-cancer therapeutic strategy. Of the 12 active CA isoforms, two, CA IX and XII, have been considered anti-cancer targets. However, other CA isoforms also show similar activity and tissue distribution in cancers and have not been considered as therapeutic targets for cancer treatment. In this review, we consider all the CA isoforms and their possible role in tumors and their potential as targets for cancer therapy.

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Section: Membrane Associated Ca Isoforms: Expression Distributionmentioning

confidence: 99%

Carbonic Anhydrases: Role in pH Control and Cancer

et al. 2018

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“…Therefore, these 2 studies are complementary and emphasize different aspects of BIA-ALCL pathogenesis for further study. Of note, occasional non-BIA-ALCLs (especially with TN genetics) showed a moderate degree of CA9 expression, highlighting the need for additional future study of hypoxia-associated pathways in T-cell neoplasms other than BIA-ALCL 28. BIA-ALCL arises in a unique tumor microenvironment consisting of the breast prosthesis, seroma fluid, and surrounding fibrous capsule.…”

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confidence: 99%

Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma

et al. 2020

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“…In NOG mice, a highly tumorigenic ATL cell was selected by serial xenotransplantation of patient leukemic cells and used to study features of ATL such as the involvement of carbonic anhydrase IX (CA9), a membrane-associated enzyme that regulates cellular pH. It was found that CA9 is upregulated and promotes tumorigenicity of ATL-derived cells [ 171 ]. A highly penetrant in vivo model of HTLV-1-induced T-cell lymphoma was established by intraperitoneally engrafting immune-compromised NOD/SCID mice with tumorigenic HTLV-1-transformed SLB1 and MET-1 lymphoma T cell lines.…”

Section: Animal Modelsmentioning

confidence: 99%

HTLV-1 Infection and Pathogenesis: New Insights from Cellular and Animal Models

Forlani

Shallak

Accolla

et al. 2021

IJMS

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Since the discovery of the human T-cell leukemia virus-1 (HTLV-1), cellular and animal models have provided invaluable contributions in the knowledge of viral infection, transmission and progression of HTLV-associated diseases. HTLV-1 is the causative agent of the aggressive adult T-cell leukemia/lymphoma and inflammatory diseases such as the HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Cell models contribute to defining the role of HTLV proteins, as well as the mechanisms of cell-to-cell transmission of the virus. Otherwise, selected and engineered animal models are currently applied to recapitulate in vivo the HTLV-1 associated pathogenesis and to verify the effectiveness of viral therapy and host immune response. Here we review the current cell models for studying virus–host interaction, cellular restriction factors and cell pathway deregulation mediated by HTLV products. We recapitulate the most effective animal models applied to investigate the pathogenesis of HTLV-1-associated diseases such as transgenic and humanized mice, rabbit and monkey models. Finally, we summarize the studies on STLV and BLV, two closely related HTLV-1 viruses in animals. The most recent anticancer and HAM/TSP therapies are also discussed in view of the most reliable experimental models that may accelerate the translation from the experimental findings to effective therapies in infected patients.

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Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T‐cell leukemia‐derived cells

Cited by 8 publications

References 34 publications

Carbonic Anhydrases: Role in pH Control and Cancer

Carbonic Anhydrases: Role in pH Control and Cancer

Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma

HTLV-1 Infection and Pathogenesis: New Insights from Cellular and Animal Models

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