Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma

Oishi, Naoki; Hundal, Tanya; Phillips, Jessica; Dasari, Surendra; Hu, Guojie; Viswanatha, David S.; He, Rong; Mai, Ming; Jacobs, Hailey K.; Ahmed, Nada; Syrbu, Sergei; Salama, Youssef; Chapman, Jennifer R.; Vega, Francisco; Sidhu, Jagmohan S.; Bennani, N. Nora; Epstein, Alan L.; Medeiros, L. Jeffrey; Clemens, Mark W.; Miranda, Roberto N.; Feldman, Andrew L.

doi:10.3324/haematol.2019.245860

Cited by 36 publications

(25 citation statements)

References 49 publications

(49 reference statements)

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“…The following human cell lines were used as positive control for validation of surface antigens. Mac2A for CD183, Mac2B for CD194 29 and TLBR1 for CD196 30 ( Supplementary Fig. S3C-E).…”

Section: Abundance Of Cd4 + Th1 Cells In Implant-associated Tissue Ofmentioning

confidence: 97%

Biofilm Derived Oxylipin Mediated Autoimmune Response in Breast Implant Subjects

Khan

Minto

Kelley-Patteson

et al. 2020

Preprint

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Over 10 million women worldwide have breast implants for breast cancer/prophylactic reconstruction or cosmetic augmentation. In recent years, a number of patients have described a constellation of symptoms that are believed to be related to their breast implants. This constellation of symptoms has been named Breast Implant Illness (BII). The symptoms described include chronic fatigue, joint pain, muscle pain and a host of other manifestations often associated with autoimmune illnesses. In this work, we report that bacterial biofilm is associated with BII. We postulate that the pathogenesis of BII is mediated via a host-pathogen interaction whereby the biofilm bacteria Staphylococcus epidermidis interacts with breast lipids to form the oxylipin 10-HOME. The oxylipin 10-HOME was found to activate CD4+ T cells to Th1 subtype. An increased abundance of CD4+Th1 was observed in the breast tissue of BII subjects. The identification of a mechanism of immune activation associated with BII via a biofilm enabled pathway provides insight into the pathogenesis for implant-associated autoimmune symptoms.

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“…The following human cell lines were used as positive control for validation of surface antigens. Mac2A for CD183, Mac2B for CD194 29 and TLBR1 for CD196 30 ( Supplementary Fig. S3C-E).…”

Section: Abundance Of Cd4 + Th1 Cells In Implant-associated Tissue Ofmentioning

confidence: 97%

Biofilm Derived Oxylipin Mediated Autoimmune Response in Breast Implant Subjects

Khan

Minto

Kelley-Patteson

et al. 2020

Preprint

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“…However, no specific pathologic features differentiating these 2 groups have been elucidated. 3 , 11 Indeed, it is unclear if these are distinct subtypes, or simply represent a spectrum of disease.…”

mentioning

confidence: 99%

“… 12 Added to this is a recent hypothesis on prosthesis-associated tissue hypoxia. 11 Aberrant gene expression is of course most likely involved in the oncogenic progression from a chronic inflammatory state to a full-blown malignancy. Recurrent JAK1 and STAT3 gene mutations have been identified and, like many other ALCLs, also identified have been mutations in DNMT3A, TP53, and SOCS.…”

mentioning

confidence: 99%

“…Recently, RNA sequencing and gene set enrichment analysis comparing eleven BIA-ALCLs to 24 non–BIA-ALCLs identified upregulation of hypoxia signaling genes including VEGFA, VEGFB, SLC2A3 (encoding GLUT3), and carbonic anyhydrase-9. 11 …”

mentioning

confidence: 99%

“… 18 Other groups are investigating unique cytokine profiles including IL-13, and molecular signatures to differentiate BIA-ALCL. 11 , 15 , 19 Apart from the significance of CD30 in diagnosis, it is also important for management. Brentuximab vedotin has been used in cases of BIA-ALCL.…”

mentioning

confidence: 99%

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Breast Implant–Associated CD30 Negative Peripheral T-Cell Lymphoma, NOS

et al. 2020

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Extranodal T- and NK-cell lymphomas

et al. 2022

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Non-cutaneous extranodal NK/T cell lymphoproliferations constitute a heterogenous group of rare neoplasms, occurring primarily in the gastro-intestinal tract, nasal area, spleen, and liver. Their nomenclature refers to their usual clinical presentation and predilection for specific anatomic sites—i.e. extranodal NK/T-cell lymphoma, nasal-type, hepatosplenic T-cell lymphoma, primary intestinal T-cell lymphomas, indolent lymphoproliferative disorders of the gastrointestinal tract, and breast implant-associated anaplastic large cell lymphoma. Extranodal tissues may also be involved by T-cell leukemias, or other entities usually presenting as nodal diseases. Primary extranodal entities range from indolent to highly aggressive diseases. Here, we will review the clinicopathologic features of the pertinent entities including the recent advances in their molecular and genetic characterization, with an emphasis on the changes introduced in the 2022 International Consensus Classification of lymphoid neoplasms, and highlight the diagnostic criteria helpful to sort out the distinction with potential mimickers.

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Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma

Abstract: profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma.

Cited by 36 publications

References 49 publications

Biofilm Derived Oxylipin Mediated Autoimmune Response in Breast Implant Subjects

Biofilm Derived Oxylipin Mediated Autoimmune Response in Breast Implant Subjects

Breast Implant–Associated CD30 Negative Peripheral T-Cell Lymphoma, NOS

Extranodal T- and NK-cell lymphomas

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