Crucial factors affecting the physicochemical properties of sol–gel produced Fe3O4@SiO2–NH2 core–shell nanomaterials

Zhang, Jianming; Zhai, Shangru; Zhai, Bin; An, Qingda; Tian, Ge

doi:10.1007/s10971-012-2864-x

Cited by 48 publications

(36 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, by applying several heating cycles for both Fe 3 O 4 and Fe 3 O 4 @GEM, the existing quantity of GEM in the functionalized sample was calculated from the mass differences (Figure 2). The first weight loss threshold identified is below the temperature of approximately 250 °C and is attributed to the evaporation of the absorbed water on the nanoparticles’ surface (water thermos-desorption [23]). The degradation of the organic chemotherapeutic takes place in two steps, between 250–350 °C and 350–500 °C.…”

Section: Resultsmentioning

confidence: 99%

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

et al. 2017

View full text Add to dashboard Cite

Nanotechnology has been successfully used for the fabrication of targeted anti-cancer drug carriers. This study aimed to obtain Fe3O4 nanoparticles functionalized with Gemcitabine to improve the cytotoxic effects of the chemotherapeutic substance on cancer cells. The (un) functionalized magnetite nanoparticles were synthesized using a modified co-precipitation method. The nanoconjugate characterization was performed by XRD, SEM, SAED and HRTEM; the functionalizing of magnetite with anti-tumor substances has been highlighted through TGA. The interaction with biologic media has been studied by means of stability and agglomeration tendency (using DLS and Zeta Potential); also, the release kinetics of the drug in culture media was evaluated. Cytotoxicity of free-Gemcitabine and the obtained nanoconjugate were evaluated on human BT 474 breast ductal carcinoma, HepG2 hepatocellular carcinoma and MG 63 osteosarcoma cells by MTS. In parallel, cellular morphology of these cells were examined through fluorescence microscopy and SEM. The localization of the nanoparticles related to the cells was studied using SEM, EDX and TEM. Hemolysis assay showed no damage of erythrocytes. Additionally, an in vivo biodistribution study was made for tracking where Fe3O4@Gemcitabine traveled in the body of mice. Our results showed that the transport of the drug improves the cytotoxic effects in comparison with the one produced by free Gemcitabine for the BT474 and HepG2 cells. The in vivo biodistribution test proved nanoparticle accumulation in the vital organs, with the exception of spleen, where black-brown deposits have been found. These results indicate that our Gemcitabine-functionalized nanoparticles are a promising targeted system for applications in cancer therapy.

show abstract

Section: Resultsmentioning

confidence: 99%

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In the FTIR spectrum of Fe 3 O 4 @SiO 2 -NH 2 nanospheres, the peaks at 796 cm -1 , 945 cm -1 , and 1060 cm -1 could be attributed to the Si-O-Si and SiO-H groups, the peak at 1563 cm -1 came from amine groups, and the peaks at 2977 cm -1 and 2917 cm -1 corresponded to -CH 2 -group of aminopropyl from APTES molecules. 46 In the FTIR spectrum of Fe 3 O 4 @PMAA, the peaks at 1706 cm -1 and 1527 cm -1 could be attributed to the C=O of the carboxyl group and the N-H of MBA, [38][39][40][41] respectively.…”

Section: Catalytic Nitrite Reductionmentioning

confidence: 99%

Synthesis of Superparamagnetic Core–Shell Structure Supported Pd Nanocatalysts for Catalytic Nitrite Reduction with Enhanced Activity, No Detection of Undesirable Product of Ammonium, and Easy Magnetic Separation Capability

Sun

Yang

Xu³

et al. 2016

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Superparamagnetic nanocatalysts could minimize both the external and internal mass transport limitations and neutralize OH(-) produced in the reaction more effectively to enhance the catalytic nitrite reduction efficiency with the depressed product selectivity to undesirable ammonium, while possess an easy magnetic separation capability. However, commonly used qusi-monodispersed superparamagnetic Fe3O4 nanosphere is not suitable as catalyst support for nitrite reduction because it could reduce the catalytic reaction efficiency and the product selectivity to N2, and the iron leakage could bring secondary contamination to the treated water. In this study, protective shells of SiO2, polymethylacrylic acid, and carbon were introduced to synthesize Fe3O4@SiO2/Pd, Fe3O4@PMAA/Pd, and Fe3O4@C/Pd catalysts for catalytic nitrite reduction. It was found that SiO2 shell could provide the complete protection to Fe3O4 nanosphere core among these shells. Because of its good dispersion, dense structure, and complete protection to Fe3O4, the Fe3O4@SiO2/Pd catalyst demonstrated the highest catalytic nitrite reduction activity without the detection of NH4(+) produced. Due to this unique structure, the activity of Fe3O4@SiO2/Pd catalysts for nitrite reduction was found to be independent of the Pd nanoparticle size or shape, and their product selectivity was independent of the Pd nanoparticle size, shape, and content. Furthermore, their superparamagnetic nature and high saturation magnetization allowed their easy magnetic separation from treated water, and they also demonstrated a good stability during the subsequent recycling experiment.

show abstract

“…Fe 3 O 4 @SiO 2 -NH 2 was synthesized following the original procedure reported previously by our groups [33][34][35]. In a typical synthesis, FeCl 3 Á6H 2 O (1.62 g), Na 3 Cit (1.50 g) and NaOAc (4.00 g) were introduced in EG (60 mL) and magnetic stirred vigorously under ambient temperature for 1 h until all components were entirely mixed to form a homogeneous yellow solution.…”

Section: Synthesis Of Chitosan Coated Magnetic Support (Fe 3 O 4 @Siomentioning

confidence: 99%

Crucial factors affecting the physicochemical properties of sol–gel produced Fe3O4@SiO2–NH2 core–shell nanomaterials

Cited by 48 publications

References 37 publications

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

Synthesis of Superparamagnetic Core–Shell Structure Supported Pd Nanocatalysts for Catalytic Nitrite Reduction with Enhanced Activity, No Detection of Undesirable Product of Ammonium, and Easy Magnetic Separation Capability

Designed synthesis of multifunctional Fe 3 O 4 @SiO 2 –NH 2 @CS–Co(II) towards efficient oxidation of ethylbenzene

Contact Info

Product

Resources

About