CRTH2 mediates the activation of human Th2 cells in response to PGD<sub>2</sub> released from IgE/anti‐IgE treated nasal polyp tissue

Pérez-Novo, Claudina; Holtappels, Gabriële; Vinall, Shân L; Xue, Luzheng; Zhang, N; Bachert, Claus; Pettipher, Roy

doi:10.1111/j.1398-9995.2009.02204.x

Cited by 25 publications

(17 citation statements)

References 33 publications

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“…The role of CRTH2 receptor in mediating chemotaxis of CD4+ Th2 lymphocytes in response to mast cell released substances has been observed [86]. Further, the migration of Th2 cells through a CRTH2 dependent mechanism via mast cells released mediators in nasal polyp tissue has also been reported [87]. More studies needed in this direction to explore the effect of lymphocyte and VIP interaction on the immune system.…”

Section: Vasoactive Intestinal Peptide Receptors Expression On Thementioning

confidence: 99%

Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases

Verma

Manohar

Venkateshaiah

et al. 2017

Cytokine & Growth Factor Reviews

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Worldwide increase incidences of allergic diseases have heightened the interest of clinicians and researchers to understand the role of neuroendocrine cells in the recruitment and activation of inflammatory cells. Several pieces of evidence revealed the association of neuropeptides in the pathogenesis of allergic diseases. Importantly, one such peptide that is secreted by neuronal cells and immune cells exerts a wide spectrum of immunological functions as cytokine/chemokine is termed as Vasoactive Intestinal Peptide (VIP). VIP mediates immunological function through interaction with specific receptors namely VPAC-1, VPAC-2, CRTH2 and PAC1 that are expressed on several immune cells such as eosinophils, mast cells, neutrophils, and lymphocytes; therefore, provide the basis for the action of VIP on the immune system. Additionally, VIP mediated action varies according to target organ depending upon the presence of specific VIP associated receptor, involved immune cells and the microenvironment of the organ. Herein, we present an integrative review of the current understanding on the role of VIP and associated receptors in allergic diseases, the presence of VIP receptors on various immune cells with particular emphasis on the role of VIP in the pathogenesis of allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis. Being crucial signal molecule of the neuroendocrine-immune network, the development of stable VIP analogue and/or antagonist may provide the future therapeutic drug alternative for the better treatment of these allergic diseases. Taken together, our current review summarizes the current understandings of VIP biology and further explore the significance of neuroendocrine cells derived VIP in the recruitment of inflammatory cells in allergic diseases that may be helpful to the investigators for planning the experiments and accordingly predicting new therapeutic strategies for combating allergic diseases. Summarized graphical abstract will help the readers to understand the significance of VIP in allergic diseases.

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Section: Vasoactive Intestinal Peptide Receptors Expression On Thementioning

confidence: 99%

Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases

Verma

Manohar

Venkateshaiah

et al. 2017

Cytokine & Growth Factor Reviews

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“…Mast cells are one of the main sources of pro-inflammatory eicosanoids, such as prostaglandin D 2 (PGD 2 ) and cysteinyl leukotrienes (cysLTs), which can affect allergic type-2 responses, activating cells such as Th2, ILC2, eosinophils, and basophils and also acting in autocrine or paracrine fashion on mast cells themselves. 1 It has been established that cysLTs can potently regulate mast cells functions through cysteinyl leukotriene type 1 receptor (CysLT 1 ) but it is still unknown whether PGD 2 can induce activation of human mast cells. 2,3 Conflicting reports have been published showing positive or negative staining for PGD 2 receptors in human tissue mast cells using immunochemistry.…”

Section: Prostaglandin D 2 Receptors In Human Mast Cellsmentioning

confidence: 99%

Prostaglandin D₂ receptors in human mast cells

Xia

Abdu

Maguire

et al. 2020

Allergy

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“…Activation of Th2 cells by PGD 2 is thought to occur predominantly through DP2/CRTH2 with concomitant increase in the production of cytokines and pro-inflammatory proteins (106, 113–115). PGD 2 binding to this receptor is also very important for CD4+ T cell trafficking and motility (116, 117).…”

Section: Eicosanoids and Related Mediators In T Cell Function/biologymentioning

confidence: 99%

Polyunsaturated Fatty Acid-Derived Lipid Mediators and T Cell Function

et al. 2014

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Fatty acids are involved in T cell biology both as nutrients important for energy production as well as signaling molecules. In particular, polyunsaturated fatty acids are known to exhibit a range of immunomodulatory properties that progress through T cell mediated events, although the molecular mechanisms of these actions have not yet been fully elucidated. Some of these immune activities are linked to polyunsaturated fatty acid-induced alteration of the composition of cellular membranes and the consequent changes in signaling pathways linked to membrane raft-associated proteins. However, significant aspects of the polyunsaturated fatty acid bioactivities are mediated through their transformation to specific lipid mediators, products of cyclooxygenase, lipoxygenase, or cytochrome P450 enzymatic reactions. Resulting bioactive metabolites including prostaglandins, leukotrienes, and endocannabinoids are produced by and/or act upon T leukocytes through cell surface receptors and have been shown to alter T cell activation and differentiation, proliferation, cytokine production, motility, and homing events. Detailed appreciation of the mode of action of these lipids presents opportunities for the design and development of therapeutic strategies aimed at regulating T cell function.

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CRTH2 mediates the activation of human Th2 cells in response to PGD₂ released from IgE/anti‐IgE treated nasal polyp tissue

Abstract: These data suggest that in immunologically activated nasal polyp tissue, PGD(2) produced by mast cells promotes the migration of Th2 cells through a CRTH2 dependent mechanism.

Cited by 25 publications

References 33 publications

Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases

Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases

Prostaglandin D₂ receptors in human mast cells

Polyunsaturated Fatty Acid-Derived Lipid Mediators and T Cell Function

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CRTH2 mediates the activation of human Th2 cells in response to PGD2 released from IgE/anti‐IgE treated nasal polyp tissue

Abstract: These data suggest that in immunologically activated nasal polyp tissue, PGD(2) produced by mast cells promotes the migration of Th2 cells through a CRTH2 dependent mechanism.

Cited by 25 publications

References 33 publications

Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases

Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases

Prostaglandin D2 receptors in human mast cells

Polyunsaturated Fatty Acid-Derived Lipid Mediators and T Cell Function

Contact Info

Product

Resources

About

CRTH2 mediates the activation of human Th2 cells in response to PGD₂ released from IgE/anti‐IgE treated nasal polyp tissue

Prostaglandin D₂ receptors in human mast cells