CRP Gene (1059G&gt;C) Polymorphism and Its Plasma Levels in Ischemic Stroke and Hemorrhagic Stroke in a South Indian Population

Das, Subhra; Roy, Sitara; Kaul, Subhash; Jyothy, A.; Munshi, Anjana

doi:10.1007/s10753-014-9897-y

Cited by 15 publications

(11 citation statements)

References 29 publications

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“…After the onset of acute ischemic stroke, the inflammatory activities could further promote the brain damage, and C-reactive protein is a common inflammatory factor which has been reported that its level is connected with the severity of neurological deficit and disability after stroke (Das, Roy, Kaul, Jyothy, & Munshi, 2004). In addition, fibrinogen, which was also detected in this study, is regarded as a key regulator of inflammation in disease.…”

Section: Discussionsupporting

confidence: 56%

Sanhuang Xiexin decoction promotes good functional outcome in acute ischemic stroke

Song

Chen

Lyu³

et al. 2018

Brain and Behavior

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ObjectivesTo explore the efficiency and safety of Sanhuang Xiexin decoction in the treatment of acute ischemic stroke (AIS) patients after endovascular intervention examination.MethodsIn this prospective observational study, 121 AIS patients admitted in our hospital were enrolled from January 2012 to December 2015. They were randomly divided into two groups, 61 patients received Sanhuang Xiexin decoction + basic treatment (SX group) and 60 patients received basic treatment (control group). The prescription of Sanhuang Xiexin decoction was taken in the SX group, with one dose (100 ml), twice a day for 7 days orally. For all patients, blood samples were drawn on the first morning and sixth morning after endovascular intervention examination under fasting state for Fib (fibrinogen), PAgT (platelet aggregation test), CRP (C‐reactive protein), and TMAO (trimethylamine oxide) tested. Estimate the changes in plasma Fib, PAgT, CRP, and TMAO levels and the syndrome of fire‐heat scores.ResultsThe plasma Fib, PAgT, CRP, and TMAO levels in the SX group were significantly lower than those in the control group (PFib < 0.01, PPAgT < 0.01, PCRP = 0.02, PTMAO < 0.01). The syndrome of fire‐heat scores in the SX group was significantly lower than that in the control group (p < 0.01). The incidences of ischemic cerebrovascular events within 3 and 6 months after endovascular intervention treatment in the SX group were lower than those in the control group (P3 month = 0.04, P6month = 0.03).ConclusionsThe prescription of Sanhuang Xiexin is efficient and safe in the treatment of AIS patients after endovascular intervention examination through reducing the inflammatory factors.

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Section: Discussionsupporting

confidence: 56%

Sanhuang Xiexin decoction promotes good functional outcome in acute ischemic stroke

Song

Chen

Lyu³

et al. 2018

Brain and Behavior

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“…It is a well-known fact that both ischemic and hemorrhagic stroke can cause inflammatory responses due to brain tissue injury that occurs in both types of stroke [14] [28]. Recently published studies found that CRP level is elevated in patients with ischemic stroke [29] and haemorrhagic stroke [30,31], which shows that inflammatory response occurs in these 2 types of stroke, which was also found in the current study. This might be explained by the general rise in CRP in the observed group of patients with risk factors for stroke: heart disease [32], atrial fibrillation, and heart failure [33].…”

Section: Discussionsupporting

confidence: 87%

Level of fibrinogen, D-dimers and C-reactive protein, and correlations between these parameters in ischemic and haemorrhagic stroke

Warpechowski¹,

Jamiołkowska²,

Ilnicki³

et al. 2021

Med Og Nauk Zdr.

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Introduction and objective. Fibrinogen (FIB) and C-reactive protein (CRP) play an important role in any inflammatory response. FIB levels may be higher in stroke patients compared to non-stroke patients. CRP is used to detect inflammation due to its high sensitivity in aseptic inflammation. Blood levels of d--dimer (DD) are used to determine the amount of fibrin formed and distributed. Inflammation may play an important role in the pathogenesis of haemorrhagic stroke causing primal damage, and in ischemic stroke causing secondary damage due to a decrease in perfusion in the brain. The aim of the study is to prove the hypothesis that the inflammatory process is involved in the pathogenesis of ischemic and haemorrhagic stroke. Materials and method. The study used data from a retrospective study conducted on a group of 402 stroke patients, among which the levels of FIB, CRP and DD were compared. The patients were hospitalized in the Department of Neurology of the Medical University (MU) in Białystok from 1 January -31 December 2016. Patients' data was obtained from medical records. The diagnosis of stroke was confirmed by CT of the head. Patients with other brain injuries were excluded from the study. The study was approved by the Bioethics Committee of the MU of Bialystok. The applied research method was the statistical method. Results. A positive moderate correlation was found between CRP and FIB. In the group of patients with ischemic stroke it was higher (0.59) than in the group of patients with haemorrhagic stroke(0.22). Moreover, in the group of patients with ischemic stroke, a correlation was found between DD and CRP(0.517). Conclusions.Inflammatory process is involved in pathogenesis of ischemic and haemorrhagic stroke, but could be associated with comorbid diseases. Increased CRP correlates with higher levels of FIB and DD in the ischemic stroke but not in the haemorrhagic stroke.

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“…A Chinese case-control study including 548 patients with acute IS and 993 age-matched control subjects indicated that rs3093059 was statistically significantly associated with IS [14]. However, controversial views still remain [18,[35][36][37] and that was in accordance with our results.…”

Section: Single Polymorphism Analysissupporting

confidence: 90%

Polymorphisms of C-reactive protein and growth arrest-specific gene 6 modulate ischemic stroke susceptibility through gene–gene interactions in Chinese Han population

Li¹,

Gao

Zhao

et al. 2020

Biotechnology & Biotechnological Equipment

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This study explored whether inflammatory gene including C-reactive protein (CRP) and growth arrest-specific gene 6 (GAS6) are related to the etiology of ischemic stroke (IS), and to verify their potential interaction upon susceptibility to IS in Chinese population. A total of 236 patients with IS and 291 non-IS subjects were enrolled. Five single nucleotide polymorphisms (SNPs) in two candidate genes (CRP and GAS6) for IS were examined and determined by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and detected by DNA sequencing. We evaluated the association between SNPs and the risk of IS and evaluated their potential gene-gene interactions by using the generalized multifactor dimensionality reduction (GMDR), interaction dendrogram, entropy analysis and Interaction circle graph. A significant gene-gene interaction was then selected. We further tested the best model by logistic regression models. The results showed no significant difference between the IS (or its subtypes) group and the control group in the single-locus of all the analyzed variants. GMDR analysis indicated that the CRP SNPs rs3093059 and the GAS6 SNPs rs7400722 shared strong synergism in LAA analysis (Testing accuracy ¼ 59.66%, CVC ¼ 10, p ¼ 0.0107). Dendrogram and circle graph analysis indicated a more-than-additive effect between the two loci. Furthermore, a recessive model of the two-locus interactions was confirmed by multivariate logistic regression model (OR ¼ 1.940, 95% CI: 1.068-3.525, p ¼ 0.030). The results indicate that CRP and GAS6 genes may fully participate in affecting the susceptibility to IS by gene-gene interaction, and may be conducive to provide a novel area for IS research.

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CRP Gene (1059G>C) Polymorphism and Its Plasma Levels in Ischemic Stroke and Hemorrhagic Stroke in a South Indian Population

Cited by 15 publications

References 29 publications

Sanhuang Xiexin decoction promotes good functional outcome in acute ischemic stroke

Sanhuang Xiexin decoction promotes good functional outcome in acute ischemic stroke

Level of fibrinogen, D-dimers and C-reactive protein, and correlations between these parameters in ischemic and haemorrhagic stroke

Polymorphisms of C-reactive protein and growth arrest-specific gene 6 modulate ischemic stroke susceptibility through gene–gene interactions in Chinese Han population

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