Sanhuang Xiexin decoction promotes good functional outcome in acute ischemic stroke

Abstract

ObjectivesTo explore the efficiency and safety of Sanhuang Xiexin decoction in the treatment of acute ischemic stroke (AIS) patients after endovascular intervention examination.MethodsIn this prospective observational study, 121 AIS patients admitted in our hospital were enrolled from January 2012 to December 2015. They were randomly divided into two groups, 61 patients received Sanhuang Xiexin decoction + basic treatment (SX group) and 60 patients received basic treatment (control group). The prescription of Sanhuang Xiexin decoction was taken in the SX group, with one dose (100 ml), twice a day for 7 days orally. For all patients, blood samples were drawn on the first morning and sixth morning after endovascular intervention examination under fasting state for Fib (fibrinogen), PAgT (platelet aggregation test), CRP (C‐reactive protein), and TMAO (trimethylamine oxide) tested. Estimate the changes in plasma Fib, PAgT, CRP, and TMAO levels and the syndrome of fire‐heat scores.ResultsThe plasma Fib, PAgT, CRP, and TMAO levels in the SX group were significantly lower than those in the control group (PFib < 0.01, PPAgT < 0.01, PCRP = 0.02, PTMAO < 0.01). The syndrome of fire‐heat scores in the SX group was significantly lower than that in the control group (p < 0.01). The incidences of ischemic cerebrovascular events within 3 and 6 months after endovascular intervention treatment in the SX group were lower than those in the control group (P3 month = 0.04, P6month = 0.03).ConclusionsThe prescription of Sanhuang Xiexin is efficient and safe in the treatment of AIS patients after endovascular intervention examination through reducing the inflammatory factors.

An ethnoveterinary study on medicinal plants used by the Buyi people in Southwest Guizhou, China

“…It is widely used for the treatment of inflammation and fever of animals. Published literature has indicated that the San-Huang Xiexin decoction promotes good functional outcomes for acute ischemic strokes [40]. Several other plants were found to be popular as veterinary medicines in the area investigated, based on their high URs, including Tetradium ruticarpum, Verbena officinalis, Ardisia crispa, Xanthium sibiricum, Perilla frutescens, Fallopia multiflora, Blumea balsamifera, Paris polyphylla, Andrographis paniculata, and Glycyrrhiza uralensis.…”

Gut Microbiota-Related Effects of Tanhuo Decoction in Acute Ischemic Stroke

“…Due to the unsatisfactory effectiveness of basic treatment with Western medicine (WM) on AIS [ 23 ], including drugs for antiplatelet (Aspirin, Clopidogrel), lowering lipid (Statins), and improving circulation (Edaravone, Alprostadil, Ureclin, and Butylphthalide), people engage in developing new drugs targeting on immune response to perform neuroprotective treatment on AIS patients [ 24 ] and also turn to the traditional Chinese medicine (TCM). TCM can remodel gut microbiota and downregulate inflammation [ 25 , 26 ] and has been proved to be an efficient intervention on stroke since 1999 or even earlier [ 27 , 28 ].…”

Modeling rapid and selective capture of nNOS–PSD-95 uncouplers from Sanhuang Xiexin decoction by novel molecularly imprinted polymers based on metal–organic frameworks

“…14,15 Modern pharmacological studies have found that SXD has a lot of bioactivities including anti-inammatory, 16 anti-oxidative, 17 antidiabetics, 18 anti-hypertension and anti-hyperlipidemia, 19 anti-atherogenic 20 and anti-cerebral ischemia reperfusion injury activities. 21 According to our preliminary experiment, SXD also had obvious uncoupling activity of nNOS-PSD-95. However, it is a time-consuming and laborious task to discover and capture powerful uncouplers from SXD due to its complicated chemical composition.…”