Abstract:Mitogenic stimulation
in vitro
of mouse T lymphocytes induces the production of the hematopoietic cytokines granulocyte–macrophage colony-stimulating factor and IL-3. The present experiments showed that simple crowding of murine spleen or lymph node cells was a sufficient inducing stimulus. Crowding did not have this consequence for thymus or marrow cells or spleen cells from
nu/nu
or
Rag-1
−/− mice lacking T lymphocytes. Crowding for as s… Show more
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