Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines

Montopoli, Monica; Bertin, Riccardo; Chen, Zheng; Bolcato, Jenny; Caparrotta, Laura; Froldi, Guglielmina

doi:10.1016/j.jep.2012.10.032

Cited by 35 publications

(18 citation statements)

References 35 publications

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“…Of C. lechleri 's two components, only the sap displayed melanoma cell cycle modulation in a dose‐dependent fashion ( p < .05). Vinblastine and taxol displayed superior efficacy in cell cycle modulation ( p < .05) (Montopoli et al, ).…”

Section: Resultsmentioning

confidence: 99%

Review of future insights of Dragon's Blood in dermatology

Pona

Cline

Kolli

et al. 2018

Dermatologic Therapy

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To assess the possible clinical implication of Dragon's Blood in dermatology, a PubMed search was conducted using the keyword “Dragon's Blood,” “Croton lechleri,” and more. Dragon's Blood from C. lechleri is an Amazonian medicinal plant with a characteristic red sap. Its array of phytochemical action in preclinical studies include anti‐inflammatory, antioxidant, antimicrobial, antifungal, and antineoplastic properties. Clinical studies reflect wound healing and antiviral properties. Although its popularity is rising in western medicine, C. lechleri offers limited use in dermatology and further investigation is necessary to gain further insight into its potential clinical implication.

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Section: Resultsmentioning

confidence: 99%

Review of future insights of Dragon's Blood in dermatology

Pona

Cline

Kolli

et al. 2018

Dermatologic Therapy

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“…In this aspect, alkaloids with cytotoxic characteristics were previously isolated from other species of genus Croton (Montopoli et al 2012). Exposure to HECC led to augmented production of ROS from 0.1 mg/mL confirming its oxidant action.…”

Section: Discussionmentioning

confidence: 99%

Oxidant effects and toxicity ofCroton campestrisinDrosophila melanogaster

Júnior

Macedo

Zemolin

et al. 2016

Pharmaceutical Biology

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Context: Croton campestris A.St.-Hil. (Euphorbiaceae) is a species native to Northeast Brazil used by traditional communities for the treatment of a variety of health problems. However, potential toxicological effects of this plant are unknown. Objective: The potential toxicity of the hydroalcoholic extract of C. campestris leaves on Drosophila melanogaster insect model, additionally with phytochemical constitution and cellular mechanisms mediating the action of extract were analysed in this study. Materials and methods: Constituents of the extract were evaluated by HPLC. In vitro antioxidant potential of extract was analysed by DPPH, ABTS and FRAP. Flies injected culture medium mixed with extract (0.1-50 mg/mL) for 72 h. After, ROS production was evaluated by DCF-DA oxidation. Phosphorylation of MAPK signalling pathway was investigated by Western blotting method. Activity of antioxidant enzymes was analysed in homogenates.Results: Major components of the extract include quercetin (38.11 ± 0.06 mg/g), caffeic acid (20.06 ± 0.17 mg/g) and kaempferol (15.45 ± 0.05 mg/g). Consumption of the extract impaired locomotor performance and induced fly death of flies (LC 50 of 26.51 mg/mL). Augmented ROS formation and SOD, CAT and GST activity were observed from 0.1 mg/mL. JNK and p38 kinases phosphorylation was modulated and Paraquat-induced toxicity was augmented by extract. Discussion and conclusion: Our data show important toxicological effects of C. campestris leading to increased mortality and impaired locomotor performance accompanied by induction of cell stress markers in flies. The study draws attention to the indiscriminate use of plant extracts. ARTICLE HISTORY

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“…A different study investigated the use of C. lechleri in comparison with taxol and vinblastine to control melanoma cancer cells. Researchers found that the plant medicine inhibited cancer cell proliferation, thus supporting the traditional use of the sap as an anticancer agent [45].…”

Section: Cancer Camas and Croton: Traditional Ecological Knowledge mentioning

confidence: 97%

Toward An Ethics of Reciprocity: Ethnobotanical Knowledge and Medicinal Plants as Cancer Therapies

Ryan

2014

Humanities

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This article develops a reciprocity ethics of the environment through a discussion of ethnobotanical medicines used in the treatment of cancer. The moral virtue of reciprocity, defined as the returning of good when good is received or anticipated, is central to the posthumanist rethinking of human relationships to the plant world. As herbal medicines are used progressively more around the globe and as plant diversity decreases as a result of habitat loss and climate change, an ethics of reciprocity should be a concern for environmental philosophers and conservationists. Aldo Leopold's land ethic and J. Baird Callicott's distinction between deontological and prudential environmental ethics provide theoretical contexts for the development of a reciprocity ethics vis-à-vis ethnobotanical species. While this article does not necessarily specify modes or forms of reciprocity, it does outline some of the more prominent ethnobotanical species used in the treatment of cancer, including those from Native American, African, Chinese, and Indian traditions. In the form of a dialogue between the fields of ethnobotany, herbal medicine, and environmental philosophy, this article presents a position from which further articulations of reciprocity can be developed, particularly those involving the rights of indigenous cultures and plants.

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Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines

Cited by 35 publications

References 35 publications

Review of future insights of Dragon's Blood in dermatology

Review of future insights of Dragon's Blood in dermatology

Oxidant effects and toxicity ofCroton campestrisinDrosophila melanogaster

Toward An Ethics of Reciprocity: Ethnobotanical Knowledge and Medicinal Plants as Cancer Therapies

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