Crosstalk of epigenetics with biological rhythmicity in animal kingdom

Ahmad, Sheikh Firdous; Shanaz, Syed; Kumar, Abhishek; Dar, Aashaq Hussain; Mohmad, Aquil; Bhushan, Bharat

doi:10.1080/09291016.2019.1607218

Cited by 2 publications

(1 citation statement)

References 59 publications

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“…As discussed in the sections above, epigenetic variations ranging from single sites to epigenome-wide maps and their regulatory mechanisms of gene expression have been reported in different tissues of several mammalian species ( Ibeagha-Awemu and Zhao, 2015 ; Chavatte-Palmer et al, 2018 ; Ahmad et al, 2019 ; Morales-Nebreda et al, 2019 ; Choi et al, 2020 ). Furthermore, association between single nucleotide polymorphisms (SNPs) and differential DNA methylation has been reported, indicating that methylation alteration leads to variable expression of related genes and thereby phenotype determination ( Banovich et al, 2014 ; Imgenberg-Kreuz et al, 2018 ).…”

Section: Application Of Epigenetics Data In Livestock Productionmentioning

confidence: 98%

Impacts of Epigenetic Processes on the Health and Productivity of Livestock

Wang

Ibeagha‐Awemu

2021

Front. Genet.

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The dynamic changes in the epigenome resulting from the intricate interactions of genetic and environmental factors play crucial roles in individual growth and development. Numerous studies in plants, rodents, and humans have provided evidence of the regulatory roles of epigenetic processes in health and disease. There is increasing pressure to increase livestock production in light of increasing food needs of an expanding human population and environment challenges, but there is limited related epigenetic data on livestock to complement genomic information and support advances in improvement breeding and health management. This review examines the recent discoveries on epigenetic processes due to DNA methylation, histone modification, and chromatin remodeling and their impacts on health and production traits in farm animals, including bovine, swine, sheep, goat, and poultry species. Most of the reports focused on epigenome profiling at the genome-wide or specific genic regions in response to developmental processes, environmental stressors, nutrition, and disease pathogens. The bulk of available data mainly characterized the epigenetic markers in tissues/organs or in relation to traits and detection of epigenetic regulatory mechanisms underlying livestock phenotype diversity. However, available data is inadequate to support gainful exploitation of epigenetic processes for improved animal health and productivity management. Increased research effort, which is vital to elucidate how epigenetic mechanisms affect the health and productivity of livestock, is currently limited due to several factors including lack of adequate analytical tools. In this review, we (1) summarize available evidence of the impacts of epigenetic processes on livestock production and health traits, (2) discuss the application of epigenetics data in livestock production, and (3) present gaps in livestock epigenetics research. Knowledge of the epigenetic factors influencing livestock health and productivity is vital for the management and improvement of livestock productivity.

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Section: Application Of Epigenetics Data In Livestock Productionmentioning

confidence: 98%

Impacts of Epigenetic Processes on the Health and Productivity of Livestock

Wang

Ibeagha‐Awemu

2021

Front. Genet.

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Characterization of body composition and liver epigenetic markers during periods of negative energy balance and subsequent compensatory growth in postpubertal beef bulls

Moura

Fonseca

Franco

et al. 2022

Journal of Animal Science

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This study aimed to characterize the effects of dietary restriction and subsequent re-alimentation on body composition and hepatic gene expression of epigenetic markers of DNA methylation, RNA m6A methylation, and histone acetylation in the liver of postpubertal beef bulls. Twelve Angus × Hereford crossbred bulls (n = 6, 23±0.55 mo (young bulls), 558±6.1 kg; and n = 6, 47±1.2 mo (mature bulls), 740±30.5 kg) were submitted to two dietary regimes per offering of the same hay: low plane of nutrition (90 days) and compensatory growth (90 days). Each animal acted as its own control and were fed Beardless wheat (Triticum aestivum) hay and mineral mix during the trial. Statistical analyses were performed using SAS 9.4 following a pre-post repeated measures design. Bulls in negative energy balance (NEB) decreased (P < 0.001) empty body weight [EBW; 23.1% (-139.1 kg)], empty body fat [EBF; 39.8% (-85.4 kg)], and empty body protein [EBP; 14.9% (-13.5 kg)] and fully recovered at the end of the trial. Body fat accounted for 77.1% of daily changes in body energy status, whereas body protein accounted for only 22.9% (P < 0.001). Relative abundance of epigenetic markers transcripts was analyzed via qPCR. Bulls at NEB tended (P ≤ 0.097) to increase gene expression of epigenetic markers of RNA m6A methylation (METTL14, VIRMA, and WTAP), and increased (P ≤ 0.050) the gene expression of epigenetic markers of DNA methylation (DNMT3A) and histone-acetylation (SIRT3 and SIRT7). Young bulls had a tendency (P ≤ 0.072) of higher RNA m6A methylation, VIRMA, and WTAP than mature bulls. Effect of diet × age interaction was not detected (P ≥ 0.137) for METTL14, VIRMA, WTAP, DNMT3A, SIRT3 or SIRT7. Younger bulls tended to have greater RNA m6A methylation levels than mature bulls, indicating that, while contemporaneously fed the same diet during periods of undernourishment followed by compensatory growth, age has an impact on this epigenetic mechanism. In conclusion, metabolic status seems to carry a greater impact on regulating bovine hepatic epigenetic mechanisms that modulate gene transcription, such as DNA methylation and histone acetylation, than on epigenetic mechanisms that regulate gene translation, such as RNA m6A methylation. During periods of undernourishment followed by compensatory growth, body fat pools appear to change more dynamically and are easily detected having a greater impact on epigenetic markers that modulate hepatic gene transcription rather than translation.

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Crosstalk of epigenetics with biological rhythmicity in animal kingdom

Cited by 2 publications

References 59 publications

Impacts of Epigenetic Processes on the Health and Productivity of Livestock

Impacts of Epigenetic Processes on the Health and Productivity of Livestock

Characterization of body composition and liver epigenetic markers during periods of negative energy balance and subsequent compensatory growth in postpubertal beef bulls

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