Crosstalk between reactive oxygen species and pro-inflammatory markers in developing various chronic diseases: a review

Ranneh, Yazan; Ali, Faris; Akim, Abdah Md; Hamid, Hasiah Abd; Khaza’ai, Huzwah; Fadel, Abdulmannan

doi:10.1007/s13765-017-0285-9

Cited by 114 publications

(54 citation statements)

References 119 publications

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“…43,44 Thus, the control of ROS is of primary importance in the treatment of IBD. Levels of MDA, an indicator of lipid peroxidation, were significantly attenuated in the plumericin-group compared to the DNBS-group (A).…”

Section: F I G U R Ementioning

confidence: 99%

Plumericin prevents intestinal inflammation and oxidative stress in vitro and in vivo

et al. 2019

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Inflammatory bowel diseases (IBDs) are characterized by an inflammatory and oxidative stress condition in the intestinal tissue. In this study, we evaluated the effect of plumericin, one of the main bioactive components of Himatanthus sucuuba (Woodson) bark, on intestinal inflammation and oxidative stress, both in vitro and in vivo. The effect of plumericin (0.5‐2 µM) in vitro was evaluated in rat intestinal epithelial cells (IEC‐6) treated with lipopolysaccharides from E. coli (10 μg/mL) plus interferon‐γ (10 U/mL). Moreover, a 2,4,6‐dinitrobenzene sulfonic acid (DNBS)‐induced colitis model was used to evaluate the anti‐inflammatory and antioxidant activity of plumericin (3 mg/kg) in vivo. The results showed that plumericin significantly reduces intestinal inflammatory factors such as tumor necrosis factor‐α, cyclooxygenase‐2 and inducible nitric oxide synthase expression, and nitrotyrosine formation. Plumericin also inhibited nuclear factor‐κB translocation, reactive oxygen species (ROS) release, and inflammasome activation. Moreover, plumericin activated the nuclear factor erythroid‐derived 2 pathway in IEC‐6. Using the DNBS‐induced colitis model, a significant reduction in the weight loss and in the development of the macroscopic and histologic signs of colon injury, together with a reduced inflammatory and oxidative stress state, were observed in plumericin‐treated mice. These results indicate that plumericin exerts a strong anti‐inflammatory and antioxidant activity. Thus, it might be a candidate for the development of a new pharmacologic approach for IBDs treatment.

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Section: F I G U R Ementioning

confidence: 99%

Plumericin prevents intestinal inflammation and oxidative stress in vitro and in vivo

et al. 2019

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“…This is the first report to separate six lignans from F. koreana flowers. [34] Accordingly, the findings prove the possibility of koreanaside A as anti-inflammatory agents. Diepoxy type lignans such as compounds 1 and 2 as well pinoresinol glycoside, kandelisesquilignans A and B, which have more than one hydroxy group in a benzene ring are reported to represent antioxidant as well anti-inflammatory effects.…”

Section: Discussionmentioning

confidence: 76%

“…[4][5] [40] Inflammation could generate various chronic diseases such as atherosclerosis, cancer, arthritis, and diabetes mellitus. [34] Accordingly, the findings prove the possibility of koreanaside A as anti-inflammatory agents. Further studies are needed to demonstrate that koreanaside A and F. koreana flowers extract could treat chronic diseases.…”

Section: Discussionmentioning

confidence: 76%

“…s, H-C(4 0 )); 6.90 (br. Because reactive oxygen species (ROS) contribute the inflammation process [34] and the compounds with antioxidant activity were reported to also inhibit inflammation factor such as iNOS, COX-2, [35] p-p65, and VCAM-1, [36] compounds 1 and 2 were evaluated for their inhibition effect on TNF-a-induced vascular cell adhesion molecule-1 (VCAM-1) expression in mouse vascular smooth muscle (MOVAS) cell line. In the oxygen and up-field region, two O-bearing methine signals (d(H) 4.64 (d, J = 4.0, H-C(7)); 4.68 (d, J = 4.0, H-C(7 0 ))), two O-bearing methylene signals (d(H) 3.79 (overlapped, H b -C(9, 9 0 )); 4.15 (dd, J = 8.0, 2.0, H a -C(9, 9 0 ))), two methoxy signals (d(H) 3.80 (s, 3 H); 3.81 (s, 3 H)), and two methine proton signals (d(H) 3.00 -3.08 (m, H-C(8, 8 0 )) were observed.…”

Section: Resultsmentioning

confidence: 99%

“…While compounds 1 -5 had more than one hydroxy group in a benzene ring. Because reactive oxygen species (ROS) contribute the inflammation process [34] and the compounds with antioxidant activity were reported to also inhibit inflammation factor such as iNOS, COX-2, [35] p-p65, and VCAM-1, [36] compounds 1 and 2 were evaluated for their inhibition effect on TNF-a-induced vascular cell adhesion molecule-1 (VCAM-1) expression in mouse vascular smooth muscle (MOVAS) cell line. [37] The cells were pretreated with the compounds (25 mg/mL) for 2 h and then stimulated with TNF-a (10 ng/mL) for 24 h. As shown in Figure 3, lignan 1 effectively prohibited the expression of VCAM-1 induced by TNF-a in MOVAS.…”

Section: Resultsmentioning

confidence: 99%

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New Lignans from the Flower of Forsythia koreana and Their Suppression Effect on VCAM‐1 Expression in MOVAS Cells

Lee

Jang

Seo

et al. 2018

Chemistry & Biodiversity

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Six lignans including two new lignans were obtained as the principal components of the Forsythia koreana flowers via silica gel (SiO ), octadecyl SiO (ODS) as well as Sephadex LH-20 column chromatography. In addition to two new lignans, named koreanaside A ((7R,8S,7'R,8'S)-7,7'-diepoxy-5'-hydroxy-3,3'-dimethoxylignan 4-O-β-d-glucopyranoside) and koreanaside B ((7R,8S,7'S,8'R)-7,9'-epoxy-9,5',7'-trihydroxy-3,3'-dimethoxylignan 4-O-β-d-glucopyranoside), four known lignans were identified to be (+)-phylligenin, (-)-epipinoresinol, pinoresinol, and tinosposide A. The structures and absolute configurations of koreanasides A and B were established by means of analysis of spectroscopic data (NMR, IR, FAB-MS, and CD), whereas the structures of known lignans were identified by comparison their NMR and MS values with those in the reported literature. Their chemical structures including configuration were established by means of analysis of spectroscopic data (NMR, IR, FAB-MS, and CD) but also comparison of their NMR and MS values with those in the reported literature. This is the first article for isolation of six lignans of F. koreana flowers. Koreanasides A and B showed high radical scavenging activity with oxygen radical absorbance capacity (ORAC) values of 0.97 ± 0.01 and 1.02 ± 0.01, respectively. Koreanaside A also prohibited expressing VCAM-1 in MOVAS cells with 80.5% at 25 mg/mL.

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Biochemical and Therapeutic Targets for Nanophytomedicines

Chakraborty¹,

Chakraborty²,

Chakraborty³

2022

Phytoantioxidants and Nanotherapeutics

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Crosstalk between reactive oxygen species and pro-inflammatory markers in developing various chronic diseases: a review

Cited by 114 publications

References 119 publications

Plumericin prevents intestinal inflammation and oxidative stress in vitro and in vivo

Plumericin prevents intestinal inflammation and oxidative stress in vitro and in vivo

New Lignans from the Flower of Forsythia koreana and Their Suppression Effect on VCAM‐1 Expression in MOVAS Cells

Biochemical and Therapeutic Targets for Nanophytomedicines

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