Crosstalk between phytochemicals and inflammatory signaling pathways

Prasad, Sonima; Kumar, Vishal; Singh, Charan; Singh, Arti

doi:10.1007/s10787-023-01206-z

Cited by 5 publications

(3 citation statements)

References 248 publications

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“…The inflammatory response and its activation pathways in kidney cells can produce early responses to kidney injury, and various molecules, such as growth factors, chemokines, adhesion molecules, proinflammatory cytokines, and molecular signatures, can be triggered and involved in the inflammatory process. Regarding the biomarkers of kidney inflammation, several previous studies illustrated that the adhesion molecules intercellular adhesion molecule-1 (ICAM-1) [48] and vascular cell adhesion molecule-1 (VCAM-1) [49] and the inflammatory cytokines interleukins (1, 6, 8, 17, 18, and 19) [50][51][52][53], tumor necrosis factor receptors (TNFR1 and TNFR2) [54], nuclear factor kappa B (NF-κB) [55], activator protein 1 (AP-1) [56], C-reactive protein (CRP) [57], and monocyte chemoattractant protein-1 (MCP-1) [58] are the most commonly used mediators to detect inflammation in clinical or nonclinical research.…”

Section: Biomarkers Of Inflammationmentioning

confidence: 99%

Currently Used Methods to Evaluate the Efficacy of Therapeutic Drugs and Kidney Safety

Huang,

Chou,

Sandar

et al. 2023

Biomolecules

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Kidney diseases with kidney failure or damage, such as chronic kidney disease (CKD) and acute kidney injury (AKI), are common clinical problems worldwide and have rapidly increased in prevalence, affecting millions of people in recent decades. A series of novel diagnostic or predictive biomarkers have been discovered over the past decade, enhancing the investigation of renal dysfunction in preclinical studies and clinical risk assessment for humans. Since multiple causes lead to renal failure, animal studies have been extensively used to identify specific disease biomarkers for understanding the potential targets and nephropathy events in therapeutic insights into disease progression. Mice are the most commonly used model to investigate the mechanism of human nephropathy, and the current alternative methods, including in vitro and in silico models, can offer quicker, cheaper, and more effective methods to avoid or reduce the unethical procedures of animal usage. This review provides modern approaches, including animal and nonanimal assays, that can be applied to study chronic nonclinical safety. These specific situations could be utilized in nonclinical or clinical drug development to provide information on kidney disease.

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Section: Biomarkers Of Inflammationmentioning

confidence: 99%

Currently Used Methods to Evaluate the Efficacy of Therapeutic Drugs and Kidney Safety

Huang,

Chou,

Sandar

et al. 2023

Biomolecules

View full text Add to dashboard Cite

show abstract

“…Moreover, Chen et al ( 17 ) demonstrated that after ESR1 phosphorylation, it could directly bind to the promoter of a member of Fos family. c-Fos forms heterodimers with a member of the proto-oncogen Jun family of transcription factors (c-Jun), resulting in an activator protein-1 (AP-1) generation, implicated in cell proliferation, invasion, differentiation ( 18 ), and inflammation ( 19 ). In addition, Güller et al ( 20 ) reported that c-Fos could contribute to hepatocarcinogenesis through stabilization of cyclin D1 within the nucleus regulators.…”

Section: Outcome Analysismentioning

confidence: 99%

“…It also reported the downregulation of c-Fos signaling by flavonoids from the peels of Citrus unshiu ( 21 ), the modulatory effects of the phytochemicals of Punica granatum against ERs ( 22 ), or even the impact of diverse phytochemicals on the production of inflammatory mediators AP-1 and MAPKs among others ( 19 ).…”

Section: Outcome Analysismentioning

confidence: 99%