Phytochemicals as estrogen receptor modulators?—a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment

Hereñú, Claudia Beatriz; Crespo, Rosana

doi:10.21037/tcr-23-1440

Transl Cancer Res

2023

DOI: 10.21037/tcr-23-1440

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Phytochemicals as estrogen receptor modulators?—a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment

Claudia Beatriz Hereñú,

Rosana Crespo

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2024

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Mechanism Research of PZD Inhibiting Lung Cancer Cell Proliferation, Invasion, and Migration based on Network Pharmacology

Feng,

Hu,

Peng

et al. 2024

CPD

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Background: A classic Chinese medicine decoction, Pinellia ternata (Thunb.) Breit.-Zingiber officinale Roscoe (Ban-Xia and Sheng-Jiang in Chinese) decoction (PZD), has shown significant therapeutic effects on lung cancer. Objective: This study aimed to explore and elucidate the mechanism of action of PZD on lung cancer using network pharmacology methods. Methods: A total of 381 components in PZD were screened, of which 16 were selected as bioactive compounds. The compound-target network consisting of 16 compounds and 79 common core targets was constructed. MTT experiment showed that the PZD extract could inhibit the cell proliferation of NCI-H1299 cells, and the IC50 was calculated as 97.34 ± 6.14 μg/mL. Transwell and wound-healing experiments showed that the PZD could significantly decrease cell migration and invasion at concentrations of 80 and 160 μg/mL, respectively. The in vitro experiments confirmed that PZD had significant therapeutic effects on lung cancer cells, mainly through the PI3K/AKT signaling pathway. Conclusion: PZD could inhibit the cell proliferation, migration, and invasion of NCI-H1299 cells partially through the PI3K/AKT signaling pathway. These findings suggested that PZD might be a potential treatment strategy for lung cancer patients.

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Mechanism Research of PZD Inhibiting Lung Cancer Cell Proliferation, Invasion, and Migration based on Network Pharmacology

Feng,

Hu,

Peng

et al. 2024

CPD

View full text Add to dashboard Cite

show abstract

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Phytochemicals as estrogen receptor modulators?—a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment

Cited by 1 publication

References 23 publications

Mechanism Research of PZD Inhibiting Lung Cancer Cell Proliferation, Invasion, and Migration based on Network Pharmacology

Mechanism Research of PZD Inhibiting Lung Cancer Cell Proliferation, Invasion, and Migration based on Network Pharmacology

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