Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

Müller, Paul; Koscsó, Balázs; Rajani, Gaurav Manohar; Stevanovic, Korey; Berres, ML; Hashimoto, Daigo; Mortha, Arthur; Leboeuf, Marylène; Li, Xiu Min; Mucida, Daniel; Stanley, E. Richard; Dahan, Stéphanie; Margolis, Kara Gross; Gershon, Michael D.; Mérad, Miriam; Bogunovic, Milena

doi:10.1016/j.cell.2014.08.002

Cited by 134 publications

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“…At steady state, ME MΦs respond to luminal bacterial infections and interact with enteric neurons to regulate GI motility 5. Once activated, resident MΦs recruit leucocytes, in particular monocytes and neutrophils to the ME, within a few hours after surgery 6.…”

Section: Introductionmentioning

confidence: 99%

CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus

Farro

Stakenborg

Gomez‐Pinilla

et al. 2017

Gut

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Section: Introductionmentioning

confidence: 99%

CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus

Farro

Stakenborg

Gomez‐Pinilla

et al. 2017

Gut

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“…Only recently researchers have started to grasp the significance of these interactions as two recent studies by Muller et al and Gabanyi at al. demonstrate 49 , 50 . Muller et al could demonstrate that large intestinal muscularis resident macrophages control the motility of the colon through release of BMP2 acting on enteric neurons which in turn provide the macrophage growth factor CSF‐1 49 .…”

Section: Murine Macrophages—safeguarding the Body's Tissue Integritymentioning

confidence: 99%

Tissue‐resident macrophages — how to humanize our knowledge

Schlitzer

Schultze

2016

Immunol Cell Biol

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Tissue macrophages of fetal and adult origin have pivotal roles in tissue homeostasis and organ inflammation. Recently several functional and transcriptomic studies have revealed their unique module-like transcriptomic organization leading to enormous tissue-dependent functional plasticity. In this review, we discuss the development, tissue adaption and function of resident murine and human macrophages. Finally, we discuss our limited knowledge on human tissue macrophages and provide our opinion on their relevance during disease and for clinical application. At last we discuss a path towards a better understanding of human tissue macrophage populations using state of the art transcriptomic and epigenetic techniques to enable understanding of these powerful tissue-resident phagocytes.

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“…Immune cells (macrophage) can influence the differentiation of ENS progenitors and the homeostasis of mature neurons and glial cells. In turn, enteric neurons and glia might also influence the responses of cells of the innate and adaptive immune system (Muller et al, ). The red arrows indicate lineage relationships.…”

Section: The Remote Effect Of the Gut Microbiota On Tissue Healing Anmentioning

confidence: 99%

The role of microbiota in tissue repair and regeneration

Shavandi

Saeedi

Gérard

et al. 2020

J Tissue Eng Regen Med

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A comprehensive understanding of the human body endogenous microbiota is essential for acquiring an insight into the involvement of microbiota in tissue healing and regeneration process in order to enable development of biomaterials with a better integration with human body environment. Biomaterials used for biomedical applications are normally germ‐free, and the human body as the host of the biomaterials is not germ‐free. The complexity and role of the body microbiota in tissue healing/regeneration have been underestimated historically. Traditionally, studies aiming at the development of novel biomaterials had focused on the effects of environment within the target tissue, neglecting the signals generated from the microbiota and their impact on tissue regeneration. The significance of the human body microbiota in relation to metabolism, immune system, and consequently tissue regeneration has been recently realised and is a growing research field. This review summarises recent findings on the role of microbiota and mechanisms involved in tissue healing and regeneration, in particular skin, liver, bone, and nervous system regrowth and regeneration highlighting the potential new roles of microbiota for development of a new generation of biomaterials.

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Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

Cited by 134 publications

References 0 publications

CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus

CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus

Tissue‐resident macrophages — how to humanize our knowledge

The role of microbiota in tissue repair and regeneration

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