The role of microbiota in tissue repair and regeneration

Shavandi, Amin; Saeedi, Pouya; Gérard, Philippe; Jalalvandi, Esmat; Cannella, David; Bekhit, Alaa El‐Din A.

doi:10.1002/term.3009

Cited by 28 publications

(23 citation statements)

References 144 publications

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“…Such growth factors come from the pancreas (insulin) or from the intestine (such as epithelial growth factor (EGF) produced by the duodenal Brunner’s glands) [ 3 , 57 , 58 , 59 ]. A change in the exposure of the remnant liver and of the remnant sinusoidal bed to gut microbial products (including lipopolysaccharides) according to liver inflow might also contribute to the modulation of the regenerative response [ 60 ]. Altogether, these results support that the increased portal inflow and the increased shear stress are inaugural stimuli after hepatectomy that fine-tune the magnitude of the proliferative response of the hepatocytes.…”

Section: Lsec During Regeneration After Partial Hepatectomymentioning

confidence: 99%

Critical Role of LSEC in Post-Hepatectomy Liver Regeneration and Failure

Rudder¹,

Dili

Stärkel

et al. 2021

IJMS

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Liver sinusoids are lined by liver sinusoidal endothelial cells (LSEC), which represent approximately 15 to 20% of the liver cells, but only 3% of the total liver volume. LSEC have unique functions, such as fluid filtration, blood vessel tone modulation, blood clotting, inflammatory cell recruitment, and metabolite and hormone trafficking. Different subtypes of liver endothelial cells are also known to control liver zonation and hepatocyte function. Here, we have reviewed the origin of LSEC, the different subtypes identified in the liver, as well as their renewal during homeostasis. The liver has the exceptional ability to regenerate from small remnants. The past decades have seen increasing awareness in the role of non-parenchymal cells in liver regeneration despite not being the most represented population. While a lot of knowledge has emerged, clarification is needed regarding the role of LSEC in sensing shear stress and on their participation in the inductive phase of regeneration by priming the hepatocytes and delivering mitogenic factors. It is also unclear if bone marrow-derived LSEC participate in the proliferative phase of liver regeneration. Similarly, data are scarce as to LSEC having a role in the termination phase of the regeneration process. Here, we review what is known about the interaction between LSEC and other liver cells during the different phases of liver regeneration. We next explain extended hepatectomy and small liver transplantation, which lead to “small for size syndrome” (SFSS), a lethal liver failure. SFSS is linked to endothelial denudation, necrosis, and lobular disturbance. Using the knowledge learned from partial hepatectomy studies on LSEC, we expose several techniques that are, or could be, used to avoid the “small for size syndrome” after extended hepatectomy or small liver transplantation.

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Section: Lsec During Regeneration After Partial Hepatectomymentioning

confidence: 99%

Critical Role of LSEC in Post-Hepatectomy Liver Regeneration and Failure

Rudder¹,

Dili

Stärkel

et al. 2021

IJMS

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“…The classical mechanisms of liver regeneration focus on signaling pathways within the liver. However, recent studies have evidenced that commensal gut microbiota plays local and systematic roles in tissue repair and regeneration (5). Therefore, it is extremely important to describe the interaction between gut microbiota and liver in the regulation of liver injury and regeneration.…”

Section: Introductionmentioning

confidence: 99%

The Gut-Liver Axis in Health and Disease: The Role of Gut Microbiota-Derived Signals in Liver Injury and Regeneration

Zheng

Wang

2021

Front. Immunol.

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Diverse liver diseases undergo a similar pathophysiological process in which liver regeneration follows a liver injury. Given the important role of the gut-liver axis in health and diseases, the role of gut microbiota-derived signals in liver injury and regeneration has attracted much attention. It has been observed that the composition of gut microbiota dynamically changes in the process of liver regeneration after partial hepatectomy, and gut microbiota modulation by antibiotics or probiotics affects both liver injury and regeneration. Mechanically, through the portal vein, the liver is constantly exposed to gut microbial components and metabolites, which have immense effects on the immunity and metabolism of the host. Emerging data demonstrate that gut-derived lipopolysaccharide, gut microbiota-associated bile acids, and other bacterial metabolites, such as short-chain fatty acids and tryptophan metabolites, may play multifaceted roles in liver injury and regeneration. In this perspective, we provide an overview of the possible molecular mechanisms by which gut microbiota-derived signals modulate liver injury and regeneration, highlighting the potential roles of gut microbiota in the development of gut microbiota-based therapies to alleviate liver injury and promote liver regeneration.

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“…The crosstalk between the gut and liver make probiotics play an important role in the progression of liver diseases (Shavandi et al, 2020). Many studies have demonstrated the beneficial effects of probiotics on the modulation of alcohol-induced liver injury, D-galactosamine-induced rat liver injury, and chronic liver disease patients (Nardone et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Lactiplantibacillus plantarum AR113 Exhibit Accelerated Liver Regeneration by Regulating Gut Microbiota and Plasma Glycerophospholipid

et al. 2022

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Emerging evidence indicates that probiotics have been proved to influence liver injury and regeneration. In the present study, the effects of Lactiplantibacillus plantarum AR113 on the liver regeneration were investigated in 70% partial hepatectomy (PHx) rats. Sprague-Dawley (SD) rats were gavaged with L. plantarum AR113 suspensions (1 × 1010 CFU/mL) both before and after partial hepatectomy. The results showed that L. plantarum AR113 administration 2 weeks before partial hepatectomy can accelerate liver regeneration by increased hepatocyte proliferation and tumor necrosis factor-α (TNF-α), hepatocyte growth factor (HGF), and transforming growth factor-β (TGF-β) expression. Probiotic administration enriched Lactobacillus and Bacteroides and depleted Flavonifractor and Acetatifactor in the gut microbiome. Meanwhile, L. plantarum AR113 showed decline of phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidyl serine (PS), and lysophosphatidyl choline (LysoPC) levels in the serum of the rats after the L. plantarum AR113 administration. Moreover, L. plantarum AR113 treated rats exhibited higher concentrations of L-leucine, L-isoleucine, mevalonic acid, and lower 7-oxo-8-amino-nonanoic acid in plasma than that in PHx. Spearman correlation analysis revealed a significant correlation between changes in gut microbiota composition and glycerophospholipid. These results indicate that L. plantarum AR113 is promising for accelerating liver regeneration and provide new insights regarding the correlations among the microbiome, the metabolome, and liver regeneration.

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The role of microbiota in tissue repair and regeneration

Cited by 28 publications

References 144 publications

Critical Role of LSEC in Post-Hepatectomy Liver Regeneration and Failure

Critical Role of LSEC in Post-Hepatectomy Liver Regeneration and Failure

The Gut-Liver Axis in Health and Disease: The Role of Gut Microbiota-Derived Signals in Liver Injury and Regeneration

Lactiplantibacillus plantarum AR113 Exhibit Accelerated Liver Regeneration by Regulating Gut Microbiota and Plasma Glycerophospholipid

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