Crossreactions in contact dermatitis

Mathelier‐Fusade, P.; Leynadier, F.

doi:10.1007/bf02737742

Cited by 4 publications

(4 citation statements)

References 41 publications

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“…It was postulated that cross-sensitization is based on the formation of common or similar haptens (11). It has been confirmed that the PPD oxidation product, Bandrowski's base (BB), play an important role in its sensitization (12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

Experimental study on skin sensitization potencies and cross‐reactivities of hair‐dye‐related chemicals in guinea pigs

et al. 2000

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In screening patch testing of hairdressers with occupational contact dermatitis, multiple positive reactions to hair dye-related chemicals, such as p-phenylenediamine (PPD), p-toluenediamine x 2HCl (PTD) and p-aminophenol (PAP), a fabric dye p-aminoazobenzene (PAB), and a tar dye Sudan III, were frequently encountered. To investigate individual skin sensitization potency and the cross-reactivities among above chemicals, a guinea pig maximization test with the above 5 chemicals was performed. In each group, 6 animals were induced with one of the chemicals at 0.1% concentration by intradermal injection and at 1.0% by topical application. The animals were challenged with all 5 chemicals in concentrations of dilution by 10 from 0.1% to 0.001%. Under the conditions of 0.1% challenges, similar sensitization potencies were observed in PPD (6/6), PTD (6/6), PAP (5/6) and PAB (6/6) groups, but no positive reactions were elicited in the Sudan III group. The cross-reactivities to PPD were confirmed in the animals challenged with PTD (6/6), PAP (6/6), PAB (6/6) and Sudan III (3/6). In the PTD-induced group, positive responses to cross-challenges were elicited by PPD (5/6), PAP (3/6), PAB (5/6) and Sudan III (1/6). The cross-reactivities to PAP were observed only with PPD (2/5) and PAB (5/5). PAB-induced animals responded only to PPD (1/6). The results indicate that all these chemicals except Sudan III are strong sensitizers. Their cross-reactivities are different in sensitized conditions, respectively. The cross-reactivities to PPD were higher than those to PTD, PAP and PAB.

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Section: Discussionmentioning

confidence: 99%

Experimental study on skin sensitization potencies and cross‐reactivities of hair‐dye‐related chemicals in guinea pigs

et al. 2000

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“…N ickel (Ni) is one of the most common contact sensitizers causing delayed-type hypersensitivity in humans (1)(2)(3)(4). Accordingly, the cellular immune response to Ni 2ϩ ions has become a model system for studying hapten-induced hypersensitivity (5-6).…”

Section: Preferential Usage Of Tcr-v␤17 By Peripheral and Cutaneous Tmentioning

confidence: 99%

Preferential Usage of TCR-Vβ17 by Peripheral and Cutaneous T Cells in Nickel-Induced Contact Dermatitis

Büdinger

Neuser²,

Totzke

et al. 2001

The Journal of Immunology

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Nickel (Ni) is one of the most common contact sensitizers in man, and Ni-induced contact dermatitis is considered as a model of hapten-induced delayed type hypersensitivity. Previous studies indicated that Ni-reactive T cells derived from Ni-allergic individuals preferentially express distinct TCR-Vβ chains. However, data on the TCR-Vβ repertoire of Ni-responsive T cells are not consistent. Therefore, the aim of this study was to identify the TCR-Vβ receptors of Ni-responsive peripheral and cutaneous T cells in a cohort of 17 donors with Ni-induced contact dermatitis in comparison with those of 6 healthy controls. Peripheral NiSO4-responsive T lymphocytes showed a significant overexpression of TCR-Vβ17 and the frequency of TCR-Vβ17+ T cells correlated significantly with the in vitro reactivity of PBMC to NiSO4. In addition, the cutaneous infiltrate of Ni-induced patch test reactions consisted primarily of Vβ17+ T cells. The majority of patch test-derived NiSO4-responsive T cells of three allergic donors were TCR-Vβ17+, whereas patch test-derived NiSO4 unresponsive T cells of four additional donors did not express TCR-Vβ17. Skin-derived Ni-responsive T cell lines from three donors uniformly secreted the Th2 cytokine, IL-5, but no IFN-γ or IL-10. These in vitro and in vivo findings strongly suggest that T cells with a restricted TCR-Vβ repertoire, i.e., Vβ17, predominate in NiSO4-induced contact dermatitis and may be crucial in the effector phase of Ni hypersensitivity.

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“…Among antibiotics, aminoglycosides currently predominate (1), but rarely tobramycin (6, 7) in spite of its frequent use. Cross‐sensitivity between aminoglycosides (3, 8–10) is related to the deoxystreptamine ring B, common to all compounds of this antibiotic class except streptomycin (10). In our case, it was not possible to rule out hypersensitivity to other aminoglycosides.…”

Section: Patch Tests Resultsmentioning

confidence: 99%