Crosslinking of poly(ε-caprolactone) by radiation technique and its biodegradability

Yoshii, Fumio; Darwis, Darmawan; Mitomo, Hiroshi; Makuuchi, Keizo

doi:10.1016/s0969-806x(99)00449-1

Cited by 62 publications

(52 citation statements)

References 4 publications

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“…The dependence noticed between mechanical response to compression over temperature can be explained by the polymeric nature of the scaffolds [23], as polymers becomes softer at higher temperature due to the weaker bonds between adjacent polymeric chains. These thermal properties were previously reported for PCL scaffolds tested either as a compact [24], [25] or a 3D structure [14], [16].…”

Section: Discussionsupporting

confidence: 84%

Mechanical response of 3D Insert® PCL to compression

Brunelli

Perrault

Lacroix

2017

Journal of the Mechanical Behavior of Biomedical Materials

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Section: Discussionsupporting

confidence: 84%

Mechanical response of 3D Insert® PCL to compression

Brunelli

Perrault

Lacroix

2017

Journal of the Mechanical Behavior of Biomedical Materials

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“…These observations were confirmed by Soedergard. [15] More detailed studies on PCL irradiation were performed by Yoshii et al, who investigated the influence of temperature and oxygen on gelation doses and crosslinking yields, [16,17] and assessed the influence of irradiation on mechanical and optical properties, susceptibility to chemical, enzymatic and biological degradation, [17][18][19] processability, [20] and thermal stability. [17] Ohrlander et al [21] discussed the structures of radicals formed by irradiation on the basis of electron spin resonance (ESR) and thermoluminescence data.…”

Section: Introductionmentioning

confidence: 99%

“…[15] More detailed studies on PCL irradiation were performed by Yoshii et al, who investigated the influence of temperature and oxygen on gelation doses and crosslinking yields, [16,17] and assessed the influence of irradiation on mechanical and optical properties, susceptibility to chemical, enzymatic and biological degradation, [17][18][19] processability, [20] and thermal stability. [17] Ohrlander et al [21] discussed the structures of radicals formed by irradiation on the basis of electron spin resonance (ESR) and thermoluminescence data. Some interesting data may also be found in papers where radiation was used as a tool for synthesizing grafted PCL, [22][23][24] polymer-polymer [25,26] or polymer-inorganic [27,28] composites, PCL-based materials with special properties (e.g., shape-memory effects), [29] or nanospheres.…”

Section: Introductionmentioning

confidence: 99%

Poly(ε‐caprolactone) Biomaterial Sterilized by E‐Beam Irradiation

Filipczak

Woźniak

Ulański

et al. 2006

Macromolecular Bioscience

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The effects of ionizing radiation (electron beam) on poly(epsilon-caprolactone) (PCL) were studied by analyzing changes in viscosity-average and weight-average molecular weight and radius of gyration, and by performing sol-gel analysis and swelling tests. Samples were irradiated under various conditions: solid and molten PCL in the presence or absence of air. The overall efficiency of crosslinking is higher for samples irradiated in the molten state than in the solid state, and is reduced in the presence of oxygen. Based on three kinds of experiments (molecular weight dependence on the dose in the pre-gelation region, sol-gel analysis, and swelling study), radiation-chemical yields of intermolecular crosslinking and scission were determined and are discussed in terms of the mechanism of radiation-induced reactions in PCL. Properties of the gels formed by high-dose irradiation and mechanical properties of irradiated PCL were analyzed. Irradiation causes an increase in the compression modulus of PCL. This process occurs at the pre-gelation stage and continues in the gel-containing system. We have demonstrated, for the first time, that irradiation of solid PCL is accompanied by a pronounced post-effect, which manifests itself by changes in the average molecular weight. EPR data indicate that this effect, at least in part, is caused by the presence of long-lived radicals trapped in the crystalline regions. Irradiation with the sterilizing dose does not cause a statistically significant change in the biocompatibility of PCL after subsequent storage for 79 d, as determined by preliminary osteoblast vitality tests.

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“…One can observe some cracks or voids in the PLLA film probably caused by the temperature of processing, as shown in Figure 8. It has mentioned before that the degradation of aliphatic polyesters can occur because of melting at high temperatures (Yoshii et al, 2000;Kodama et al, 1997). morphological changes.…”

Section: Energy (Kev)mentioning

confidence: 99%

“…In this sense, poly(L-lactic acid) (PLLA) and poly(ε-caprolactone) (PCL) have been receiving much attention lately due to their biodegradability in human body as well as in the soil, biocompatibility, environmentally friendly characteristics and non-toxicity (Tsuji & Ikada, 1996;Kammer & Kummerlowe, 1994;Dell'Erba et al, 2001;Yoshii et al, 2000;Zhang et al, 2005). The controlled degradation of polymers is sometimes desired for biomedical applications and environmental purposes (Michler, 2008).…”

Section: Introductionmentioning

confidence: 99%