Crosslinked porous three-dimensional cellulose nanofibers-gelatine biocomposite scaffolds for tissue regeneration

Mirtaghavi, Ali; Baldwin, Andrew K.; Tanideh, Nader; Zarei, Moein; Muthuraj, Rajendran; Cao, Yuan; Zhao, Gang; Geng, Junfeng; Jin, Hao; Luo, Jikui

doi:10.1016/j.ijbiomac.2020.08.066

Cited by 33 publications

(15 citation statements)

References 41 publications

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“…Due to the anti-oxidative, anti-inflammatory and anti-tumoral activity of CUR, this natural active material has been selected for reducing the inflammations in different studies [33]. According to various studies, CUR triggered anti-inflammatory, bioactivity and biocompatibility in different structures, when combined with silk, gelatin, collagen and chitosan [34][35][36][37]. CUR has also been studied in combination with different polymers to produce electrospun scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Poly(3-Hydroxybutyrate)-Multiwalled Carbon Nanotubes Electrospun Scaffolds Modified with Curcumin

et al. 2020

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Appropriate selection of suitable materials and methods is essential for scaffolds fabrication in tissue engineering. The major challenge is to mimic the structure and functions of the extracellular matrix (ECM) of the native tissues. In this study, an optimized 3D structure containing poly(3-hydroxybutyrate) (P3HB), multiwalled carbon nanotubes (MCNTs) and curcumin (CUR) was created by electrospinning a novel biomimetic scaffold. CUR, a natural anti-inflammatory compound, has been selected as a bioactive component to increase the biocompatibility and reduce the potential inflammatory reaction of electrospun scaffolds. The presence of CUR in electrospun scaffolds was confirmed by 1H NMR and Fourier-transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) revealed highly interconnected porosity of the obtained 3D structures. Addition of up to 20 wt% CUR has enhanced mechanical properties of the scaffolds. CUR has also promoted in vitro bioactivity and hydrolytic degradation of the electrospun nanofibers. The developed P3HB-MCNT composite scaffolds containing 20 wt% of CUR revealed excellent in vitro cytocompatibility using mesenchymal stem cells and in vivo biocompatibility in rat animal model study. Importantly, the reduced inflammatory reaction in the rat model after 8 weeks of implantation has also been observed for scaffolds modified with CUR. Overall, newly developed P3HB-MCNTs-CUR electrospun scaffolds have demonstrated their high potential for tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Poly(3-Hydroxybutyrate)-Multiwalled Carbon Nanotubes Electrospun Scaffolds Modified with Curcumin

et al. 2020

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“…6c. There was no yield occurred at a strain of up to 86%, which was a typical deformation behavior of porous materials (Mirtaghavi et al 2020). When the strain reached 86%, the compressive stress of PP-CNF-AG was 37.67 kPa, compression stress values of PP-TOCNF-2.5-AG, PP-TOCNF-5-AG and PP-TOCNF-10-AG were 34.16, 18.13 and 14.45 kPa, respectively.…”

Section: Mechanical Property Analysesmentioning

confidence: 87%

Tuning the properties of pineapple peel cellulose nanofibrils by TEMPO-mediated oxidation and ball milling

Luo²,

Chen

et al. 2022

Cellulose

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In this study, the oxidized cellulose nano brils from pineapple peel (PP-TOCNF) were prepared by TEMPOmediated oxidation followed by ball milling. The in uence of oxidation degree on the structure and properties of PP-TOCNF were investigated, including Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), atomic force microscope (AFM), X-ray photoelectron spectroscopy (XPS) and thermogravimetry (TG), as well as the potential application in aerogels. The results suggested that TEMPO oxidation facilitated the dispersion of PP-TOCNF due to the strong electrostatic repulsion between -COO − groups. Regulating oxidation degree by varying NaClO concentration could effectively adjust the -COO − content (0.167 ~ 0.550 mmol/g), zeta potential (-18 ~ -34 mV) and rheological properties. The obtained PP-TOCNF showed a long brillar structure, whose average diameter and CrI values gradually decreased with the increase of oxidation degree. The PP-TOCNF-based aerogels exhibited a light weight, good porosity, water absorption, and mechanical properties, which also can be easily adjusted by oxidation degree of PP-TOCNF. Furthermore, TEMPO oxidation improved the stability and shape recovery ability of aerogels in water.

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“…In addition, the surface properties of individual cellulose nanofibrils may be controlled through oxidative treatments. These advantages have made CNFs a preferred nano‐filler for many studies involving the development of materials for TE applications (Aarstad et al, 2017; Campodoni et al, 2019; Carlström et al, 2020; Cheng et al, 2019; Doench et al, 2018, 2019; Du et al, 2019; Gorgieva et al, 2017; Hickey & Pelling, 2019; Lohrasbi et al, 2020; Lungu et al, 2021; Maharjan et al, 2021; Mirtaghavi et al, 2020; Syverud, 2017; Tavakoli et al, 2021; Y. Zhang et al, 2019).…”

Section: Nanocomposite Hydrogels Incorporating Functionalized Nanomat...mentioning

confidence: 99%

Nanoengineered biomimetic hydrogels: A major advancement to fabricate 3D‐printed constructs for regenerative medicine

Cernencu

Dinu

Stancu

et al. 2022

Biotech & Bioengineering

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Nanostructured compounds already validated as performant reinforcements for biomedical applications together with different fabrication strategies have been often used to channel the biophysical and biochemical features of hydrogel networks. Ergo, a wide array of nanostructured compounds has been employed as additive materials integrated with hydrophilic networks based on naturally‐derived polymers to produce promising scaffolding materials for specific fields of regenerative medicine. To date, nanoengineered hydrogels are extensively explored in (bio)printing formulations, representing the most advanced designs of hydrogel (bio)inks able to fabricate structures with improved mechanical properties and high print fidelity along with a cell‐interactive environment. The development of printing inks comprising organic–inorganic hybrid nanocomposites is in full ascent as the impact of a small amount of nanoscale additive does not translate only in improved physicochemical and biomechanical properties of bioink. The biopolymeric nanocomposites may even exhibit additional particular properties engendered by nano‐scale reinforcement such as electrical conductivity, magnetic responsiveness, antibacterial or antioxidation properties. The present review focus on hydrogels nanoengineered for 3D printing of biomimetic constructs, with particular emphasis on the impact of the spatial distribution of reinforcing agents (0D, 1D, 2D). Here, a systematic analysis of the naturally‐derived nanostructured inks is presented highlighting the relationship between relevant length scales and size effects that influence the final properties of the hydrogels designed for regenerative medicine.

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Crosslinked porous three-dimensional cellulose nanofibers-gelatine biocomposite scaffolds for tissue regeneration

Cited by 33 publications

References 41 publications

Poly(3-Hydroxybutyrate)-Multiwalled Carbon Nanotubes Electrospun Scaffolds Modified with Curcumin

Poly(3-Hydroxybutyrate)-Multiwalled Carbon Nanotubes Electrospun Scaffolds Modified with Curcumin

Tuning the properties of pineapple peel cellulose nanofibrils by TEMPO-mediated oxidation and ball milling

Nanoengineered biomimetic hydrogels: A major advancement to fabricate 3D‐printed constructs for regenerative medicine

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